Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.23.17 (PCE)
 1,301 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analyses of lipid extracts from rabbit meat were carried out by gas chromatography/mass spectrometry (GC/mS) using both electron and chemical ionisation. Ten rabbit carcasses were randomly acquired on the market, from different farms; for each of them muscular tissues from hindleg and breast were analysed. The lipid fractions were extracted, separated and hydrolysed. The fatty acid fractions were derivatised by 2,2-dimethoxypropane. The GC/mS data obtained using electron ionisation (EI) did not allow the complete characterisation of the fatty acid fraction, and for this reason chemical ionisation (CI) was employed using acetonitrile as reactant gas. The data thus obtained show that, for both samples of rabbit tissue, the mean abundance ratio of plasma cholesterol lowering fatty acids and plasma cholesterol elevating fatty acids (PCL/PCE), taken as a parameter describing a desirable lipid uptake, is 2.2 +/- 0.3, significantly higher than the values reported for other meats (0.8-1. 8). These data, together with the high concentration of (n-6) fatty acids, provide a good indication of the high nutritional value of rabbit meat.
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PMID:Qualitative and quantitative analysis of lipid extracts from rabbit meat by gas chromatography/mass spectrometry. 1052 84

A series of amphiphilic random block co-polymers were synthesized by the condensation of hydrophobic polycaprolactone diol (PCL diol) with hydrophilic dicarboxy poly(ethylene glycol) (PEG-diacid), obtained by reacting poly(ethylene glycol) (PEG) with succinic anhydride. The PEG/PCL random block co-polymers were then acrylated with acryloyl chloride to form PEG/PCL diacrylates (PCEdA), and then characterized by FT-IR, (1)H-NMR and GPC. The porous biodegradable gels were prepared through photo-polymerization of the PCEdA dissolved in DMSO at low temperature. Thermal behavior, swelling ratio and morphological characteristics as well as biodegradability of the presented gels were investigated. Results showed that the swelling ratio of the gel in deionized water increased with an increase of the PEG chain length in the copolymeric gel. DSC thermograms indicated that the melting point of the PCEdA was lower than that of PCL and PEG blocks, but a new crystalline peak of the co-polymeric gel appeared with increasing of the segmental length of the PEG. Thermal stability of PCE gel was higher than that of PCE diol. The pore size of the gel was influenced by the concentration of PCEdA. The drug-release behavior of PCE gels was also investigated.
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PMID:Synthesis and drug-release behavior of porous biodegradable amphiphilic co-polymeric hydrogels. 1987 75

In this work, a novel pH-sensitive hydrogels based on macromonomer of methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PCE-AC), poly(ethylene glycol) methyl ether methacrylate (MPEGMA), and methacrylic acid (MAA) were successfully synthesized by heat-initiated free radical polymerization method. The obtained macromonomers and hydrogels were characterized by (1)H NMR and FT-IR, respectively. Morphology study, swelling behavior, in vitro drug release behavior, acute oral toxicity of hydrogels, and cytotoxicity of PCE-AC macromonomer were also investigated in this paper. Finally, the hydrogels demonstrated that the sharp change in different pH value, thus believing to be promising the suitability of the candidate for oral drug-delivery systems.
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PMID:Synthesis and characterization of poly(methoxyl ethylene glycol-caprolactone-co-methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate) pH-sensitive hydrogel for delivery of dexamethasone. 2009 58