Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.17 (
PCE
)
1,301
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A biological process for remediation of groundwater contaminated with tetrachloroethylene (
PCE
) and trichloroethylene (TCE) can only be applied if the transformation products are environmentally acceptable. Studies with enrichment cultures of
PCE
- and TCE-degrading microorganisms provide evidence that, under methanogenic conditions, mixed cultures are able to completely dechlorinate
PCE
and TCE to ethylene, a product which is environmentally acceptable. Radiotracer studies with [14C]
PCE
indicated that [14C]ethylene was the terminal product; significant conversion to 14CO2 or 14CH4 was not observed. The rate-limiting step in the pathway appeared to be conversion of vinyl chloride to ethylene. To sustain reductive dechlorination of
PCE
and TCE, it was necessary to supply an electron donor; methanol was the most effective, although hydrogen, formate, acetate, and glucose also served. Studies with the
inhibitor 2
-bromoethanesulfonate suggested that methanogens played a key role in the observed biotransformations of
PCE
and TCE.
...
PMID:Biological reductive dechlorination of tetrachloroethylene and trichloroethylene to ethylene under methanogenic conditions. 255 19
