Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.17 (
PCE
)
1,301
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A series of amphiphilic random block co-polymers were synthesized by the condensation of hydrophobic polycaprolactone diol (PCL diol) with hydrophilic dicarboxy poly(ethylene glycol) (PEG-diacid), obtained by reacting poly(ethylene glycol) (PEG) with succinic anhydride. The PEG/PCL random block co-polymers were then acrylated with
acryloyl chloride
to form PEG/PCL diacrylates (PCEdA), and then characterized by FT-IR, (1)H-NMR and GPC. The porous biodegradable gels were prepared through photo-polymerization of the PCEdA dissolved in DMSO at low temperature. Thermal behavior, swelling ratio and morphological characteristics as well as biodegradability of the presented gels were investigated. Results showed that the swelling ratio of the gel in deionized water increased with an increase of the PEG chain length in the copolymeric gel. DSC thermograms indicated that the melting point of the PCEdA was lower than that of PCL and PEG blocks, but a new crystalline peak of the co-polymeric gel appeared with increasing of the segmental length of the PEG. Thermal stability of
PCE
gel was higher than that of
PCE
diol. The pore size of the gel was influenced by the concentration of PCEdA. The drug-release behavior of
PCE
gels was also investigated.
...
PMID:Synthesis and drug-release behavior of porous biodegradable amphiphilic co-polymeric hydrogels. 1987 75
In this work, a novel pH-sensitive hydrogels based on macromonomer of methoxyl poly(ethylene glycol)-poly(caprolactone)-
acryloyl chloride
(MPEG-PCL-AC,
PCE
-AC), poly(ethylene glycol) methyl ether methacrylate (MPEGMA), and methacrylic acid (MAA) were successfully synthesized by heat-initiated free radical polymerization method. The obtained macromonomers and hydrogels were characterized by (1)H NMR and FT-IR, respectively. Morphology study, swelling behavior, in vitro drug release behavior, acute oral toxicity of hydrogels, and cytotoxicity of
PCE
-AC macromonomer were also investigated in this paper. Finally, the hydrogels demonstrated that the sharp change in different pH value, thus believing to be promising the suitability of the candidate for oral drug-delivery systems.
...
PMID:Synthesis and characterization of poly(methoxyl ethylene glycol-caprolactone-co-methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate) pH-sensitive hydrogel for delivery of dexamethasone. 2009 58
