Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.17 (PCE)
 1,301 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of simultaneous pretreatment with vitamins C and E on the toxicity and mutagenicity of K2Cr2O7 in rats and guinea pigs was evaluated. Dietary pretreatment of Cr(VI)-intoxicated rats with ascorbic acid or alpha-tocopherol normalized vitamin C levels in lungs but not in kidneys. The synergistic preventive effect of both vitamins was confirmed in the production of lipoperoxides in Cr(VI)-intoxicated rats. Simultaneous administration of vitamins C and E in guinea pigs prevented the decrease of vitamin C levels provoked by the oxidative effects of Cr(VI). The results of the micronucleus test in bone marrow showed that it was vitamin C that caused the antimutagenic effect against bichromate, in both rats and guinea pigs. The effect of vitamin E was demonstrated only in an increase of the ratio of NCE to PCE, i.e., in a decrease of the cytotoxic but not the mutagenic effects of hexavalent chromium.
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PMID:Effect of vitamins C and E on toxicity and mutagenicity of hexavalent chromium in rat and guinea pig. 198 83

Significant increase in the salivary gland weight was observed after exposure to single therapeutic dose of 3.7 MBq of 131I in mice. Pre-supplementation of antioxidants, O. sanctum leaf extract, turmeric extract and vitamin E for 15 days before 131I exposure demonstrated significant reduction in the salivary gland weight. No major histopathological changes were observed in the salivary gland of experimental animals at 24 h of exposure. Micronuclei index in the bone marrow of polychromatic (PCEs) and normochromatic erythrocytes (NCEs) remained unchanged in all the experimental groups. However, PCE/NCE ratio in the bone marrow decreased significantly in all the 131I exposed animals irrespective of antioxidant supplementation status. The normalization of salivary gland weight by antioxidant pre-supplementation in radioiodine exposed mice is suggestive of the possible ameliorating effect of antioxidants on the salivary gland weight recommending further detailed studies regarding the functional aspect of the salivary gland in higher animals.
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PMID:Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice. 2088 58