Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.17 (
PCE
)
1,301
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A series of amphiphilic random block co-polymers were synthesized by the condensation of hydrophobic polycaprolactone diol (PCL diol) with hydrophilic dicarboxy poly(ethylene glycol) (
PEG
-diacid), obtained by reacting poly(ethylene glycol) (
PEG
) with succinic anhydride. The
PEG
/PCL random block co-polymers were then acrylated with acryloyl chloride to form
PEG
/PCL diacrylates (PCEdA), and then characterized by FT-IR, (1)H-NMR and GPC. The porous biodegradable gels were prepared through photo-polymerization of the PCEdA dissolved in DMSO at low temperature. Thermal behavior, swelling ratio and morphological characteristics as well as biodegradability of the presented gels were investigated. Results showed that the swelling ratio of the gel in deionized water increased with an increase of the
PEG
chain length in the copolymeric gel. DSC thermograms indicated that the melting point of the PCEdA was lower than that of PCL and
PEG
blocks, but a new crystalline peak of the co-polymeric gel appeared with increasing of the segmental length of the
PEG
. Thermal stability of
PCE
gel was higher than that of
PCE
diol. The pore size of the gel was influenced by the concentration of PCEdA. The drug-release behavior of
PCE
gels was also investigated.
...
PMID:Synthesis and drug-release behavior of porous biodegradable amphiphilic co-polymeric hydrogels. 1987 75
