Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.16 (
HIV-1 protease
)
2,107
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
169
protease inhibitor
163
Mol
143
Gag
132
NMR
94
gag
83
Pol
81
P2'
71
dimeric
68
pol
57
CD4
51
integrase
45
p24
38
polypeptide
26
MT-4
26
SOD
25
fused
25
renin
25
aspartyl protease
24
Gag polyprotein
23
p66
21
RNase H
20
SAR
20
thrombin
20
ACS
19
GRL
19
insulin
18
p51
18
cytochrome P450
18
hinge
18
P-glycoprotein
17
Boc
16
p17
16
cathepsin D
16
PDB
15
NL4
15
Met
14
dihydrofolate reductase
13
gem
13
p55
12
p24 antigen
12
MT-2
12
glycoprotein
11
SDS
11
precursor protein
11
TMC
10
serum albumin
9
lysozyme
9
CYP3A4
9
neuraminidase
9
non-active
8
HINT
8
EPR
8
vimentin
8
SARS
8
Gag protein
8
Nle
8
cytokine
7
env
7
F11
7
matrix protein
7
cage
7
CCR5
7
p15
6
SP1
6
BACE1
6
Gen
6
MDR1
6
tRNA
6
serine protease
6
lymphoid
6
crystallin
6
ROD
6
kit
6
Leu5
5
SIV
5
HLA
5
DNA polymerase
5
CHA
5
proteasome
5
more...
Disease
HIV
1007
immunodeficiency
389
AIDS
292
Human immunodeficiency virus type
29
leukemia
27
cancer
24
SAR
20
lipodystrophy
16
tumor
15
PDB
15
virus infection
14
CEM
14
SARS
12
malaria
11
SDS
11
hepatitis C
10
Rous sarcoma
10
viremia
9
infectious diseases
9
Infection
9
Alzheimer's disease
9
candidiasis
7
hyperlipidemia
7
influenza
7
cytomegalovirus
6
fits
6
diabetes
6
stomatitis
5
hypertension
5
encephalitis
5
dyslipidemia
5
West
5
Kaposi's sarcoma
5
vaccinia
5
Mycobacterium
4
leishmaniasis
4
Dissociation
4
NS3
4
achondroplasia
4
myelopathy
4
HTLV-I
4
glucose intolerance
4
STD
4
cataract
4
dementia
4
plaque
3
hepatitis B
3
adult T-cell leukemia/lymphoma
3
wasting
3
suicide
3
PLS
3
GSH
3
myeloid leukemia
3
tuberculosis
3
glioblastoma
3
latent infection
3
SCID
3
HAM
3
encephalomyelitis
2
sarcoma
2
subacute sclerosing panencephalitis
2
hepatitis
2
substance use
2
TEM
2
SMD
2
TEM
2
avian influenza
2
mammary tumor
2
idiopathic thrombocytopenic purpura
2
myeloblastosis
2
MCF
2
renal disease
2
cervical cancer
2
anemia
2
hypercholesterolemia
2
rash
2
cardiovascular disease
2
lipomatosis
2
FTC
2
mimicry
2
more...
Symptom
diarrhea
8
nausea
4
collapse
3
starvation
1
dyspnea
1
general problem
1
acidity
1
vomiting
1
angina
1
abdominal discomfort
1
asthenia
1
weakness
1
splenomegaly
1
Drug
Asn
40
Darunavir
32
ROC
23
THF
20
Indinavir
19
AZT
18
AZT
18
ATV
17
Biopolymers
14
TMC114
12
TPV
8
lysine
6
Monit
5
Crixivan
4
Crixivan
4
Crixivan
4
Fosamprenavir
4
Agenerase
3
IL-2
3
NLF
3
Fosamprenavir calcium
2
Norvir
2
Glide
2
Gel
2
Fragment
2
ACT
2
Alanine
2
Taxol
2
ddI
2
Cisapride
1
Acacia
1
Mutagen
1
Glycerol
1
Rosiglitazone
1
Prezista
1
caffeine
1
Kenyan
1
Maltose
1
Reverset
1
Etravirine
1
Trusopt
1
Lipidex
1
Glutathione
1
Onconase
1
CTX
1
G418
1
CPO
1
Gastro
1
Albumin
1
NVP
1
monobasic sodium phosphate
1
Sodium nitroprusside
1
Fluorescein
1
ABC
1
Rosuvastatin
1
Lexiva
1
Cardiovasc
1
Avobenzone
1
Trusopt
1
Invirase
1
Pepstatin
1
Dihydro
1
Tenofovir
1
Fluorescein
1
Viracept
1
Aztec
1
Compound 19
1
Leaf
1
Sulfamide
1
PMPA
1
Vitamin E
1
Ditekiren
1
Tacrolimus
1
PMEA
1
Epivir
1
Enzyme
HIV-1 protease
2107
reverse transcriptase
220
pepsin
31
renin
25
RNase H
23
trypsin
20
thrombin
19
ACS
19
P-glycoprotein
17
cathepsin D
15
dihydrofolate reductase
15
MDR
12
RNA polymerase
10
neuraminidase
9
CYP3A4
9
beta-galactosidase
9
lysozyme
9
transcriptase
8
protein kinase
8
glutathione S-transferase
7
RNase
7
elastase
6
subtilisin
6
endothiapepsin
6
ERK
6
RNase
6
DNA polymerase
6
chymotrypsin
5
thromboplastin
5
proteasome
5
endonuclease
5
ATPase
5
ribonuclease
5
ribonuclease
5
thymidylate synthase
4
focal adhesion kinase
4
beta-secretase
4
plasmepsin II
4
acetylcholinesterase
3
luciferase
3
papain
3
thymidine kinase
3
rhizopuspepsin
3
caspase-3
3
peroxidase
3
ricin
3
lipase
3
protein kinase C
3
phenylalanine hydroxylase
2
2A protease
2
carbonic anhydrase
2
galactokinase
2
adenosine kinase
2
superoxide dismutase
2
chymase
2
glyceraldehyde-3-phosphate dehydrogenase
2
sulfatase
2
glyceraldehyde-3-phosphate dehydrogenase
2
PARP
2
thermolysin
2
cathepsin K
2
glyceraldehyde-3-phosphate dehydrogenase
2
plasmin
2
carboxypeptidase A
2
adenylate kinase
2
creatine kinase
2
tryptophan synthase
2
gastricsin
2
glyceraldehyde-3-phosphate dehydrogenase
2
cathepsin G
2
MMP
2
tryptase
2
glyceraldehyde-3-phosphate dehydrogenase
2
ACE
2
hydroxynitrile lyase
1
mitogen-activated protein kinase
1
nepenthesin
1
mu-calpain
1
coronavirus main proteinase
1
PRE
1
more...
Compound
hydrogen
231
Dec
145
water
134
Asp
82
Phe
75
DNA
67
urea
65
Ile
58
alanine
58
leucine
51
tyrosine
46
Clin
42
arginine
41
oxygen
38
aspartic acid
31
Gly
31
nitrogen
30
threonine
30
NH2
29
aspartic acid
29
aspartic acid
29
aspartic acid
29
THF
27
Ritonavir
26
cysteine
26
hydroxyethylamine
25
salt
23
lysine
23
His
22
methionine
22
KNI-272
21
valine
21
Amprenavir
21
THF
20
AZT
19
ACS
19
Indinavir
19
ACS
19
serine
18
tryptophan
17
proline
17
Nelfinavir
17
PDB
15
methanol
13
Lopinavir
13
MDR
12
SDS
11
glucose
11
sodium
11
calcium
10
MTT
10
TMC
10
zinc
9
COS
9
acetate
9
tryptophan
9
phosphate
9
tryptophan
9
acetonitrile
9
tryptophan
9
isoleucine
8
isoleucine
8
pyrrolidine
7
PEG
7
pyrrolidine
7
PNU
7
glutamic acid
7
sulfate
7
sulfamide
7
sulfamide
7
acetic acid
7
HCl
6
guanidine
6
benzamide
6
asparagine
6
naphthalene
5
pyridine
5
benzene
5
fluorine
5
ammonium
5
more...