Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.16 (HIV-1 protease)
2,107 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 169
protease inhibitor 163
Mol 143
Gag 132
NMR 94
gag 83
Pol 81
P2' 71
dimeric 68
pol 57
CD4 51
integrase 45
p24 38
polypeptide 26
MT-4 26
SOD 25
fused 25
renin 25
aspartyl protease 24
Gag polyprotein 23
p66 21
RNase H 20
SAR 20
thrombin 20
ACS 19
GRL 19
insulin 18
p51 18
cytochrome P450 18
hinge 18
P-glycoprotein 17
Boc 16
p17 16
cathepsin D 16
PDB 15
NL4 15
Met 14
dihydrofolate reductase 13
gem 13
p55 12
p24 antigen 12
MT-2 12
glycoprotein 11
SDS 11
precursor protein 11
TMC 10
serum albumin 9
lysozyme 9
CYP3A4 9
neuraminidase 9
non-active 8
HINT 8
EPR 8
vimentin 8
SARS 8
Gag protein 8
Nle 8
cytokine 7
env 7
F11 7
matrix protein 7
cage 7
CCR5 7
p15 6
SP1 6
BACE1 6
Gen 6
MDR1 6
tRNA 6
serine protease 6
lymphoid 6
crystallin 6
ROD 6
kit 6
Leu5 5
SIV 5
HLA 5
DNA polymerase 5
CHA 5
proteasome 5
more...
Disease
HIV 1007
immunodeficiency 389
AIDS 292
Human immunodeficiency virus type 29
leukemia 27
cancer 24
SAR 20
lipodystrophy 16
tumor 15
PDB 15
virus infection 14
CEM 14
SARS 12
malaria 11
SDS 11
hepatitis C 10
Rous sarcoma 10
viremia 9
infectious diseases 9
Infection 9
Alzheimer's disease 9
candidiasis 7
hyperlipidemia 7
influenza 7
cytomegalovirus 6
fits 6
diabetes 6
stomatitis 5
hypertension 5
encephalitis 5
dyslipidemia 5
West 5
Kaposi's sarcoma 5
vaccinia 5
Mycobacterium 4
leishmaniasis 4
Dissociation 4
NS3 4
achondroplasia 4
myelopathy 4
HTLV-I 4
glucose intolerance 4
STD 4
cataract 4
dementia 4
plaque 3
hepatitis B 3
adult T-cell leukemia/lymphoma 3
wasting 3
suicide 3
PLS 3
GSH 3
myeloid leukemia 3
tuberculosis 3
glioblastoma 3
latent infection 3
SCID 3
HAM 3
encephalomyelitis 2
sarcoma 2
subacute sclerosing panencephalitis 2
hepatitis 2
substance use 2
TEM 2
SMD 2
TEM 2
avian influenza 2
mammary tumor 2
idiopathic thrombocytopenic purpura 2
myeloblastosis 2
MCF 2
renal disease 2
cervical cancer 2
anemia 2
hypercholesterolemia 2
rash 2
cardiovascular disease 2
lipomatosis 2
FTC 2
mimicry 2
more...
Symptom
diarrhea 8
nausea 4
collapse 3
starvation 1
dyspnea 1
general problem 1
acidity 1
vomiting 1
angina 1
abdominal discomfort 1
asthenia 1
weakness 1
splenomegaly 1
Drug
Asn 40
Darunavir 32
ROC 23
THF 20
Indinavir 19
AZT 18
AZT 18
ATV 17
Biopolymers 14
TMC114 12
TPV 8
lysine 6
Monit 5
Crixivan 4
Crixivan 4
Crixivan 4
Fosamprenavir 4
Agenerase 3
IL-2 3
NLF 3
Fosamprenavir calcium 2
Norvir 2
Glide 2
Gel 2
Fragment 2
ACT 2
Alanine 2
Taxol 2
ddI 2
Cisapride 1
Acacia 1
Mutagen 1
Glycerol 1
Rosiglitazone 1
Prezista 1
caffeine 1
Kenyan 1
Maltose 1
Reverset 1
Etravirine 1
Trusopt 1
Lipidex 1
Glutathione 1
Onconase 1
CTX 1
G418 1
CPO 1
Gastro 1
Albumin 1
NVP 1
monobasic sodium phosphate 1
Sodium nitroprusside 1
Fluorescein 1
ABC 1
Rosuvastatin 1
Lexiva 1
Cardiovasc 1
Avobenzone 1
Trusopt 1
Invirase 1
Pepstatin 1
Dihydro 1
Tenofovir 1
Fluorescein 1
Viracept 1
Aztec 1
Compound 19 1
Leaf 1
Sulfamide 1
PMPA 1
Vitamin E 1
Ditekiren 1
Tacrolimus 1
PMEA 1
Epivir 1
Enzyme
HIV-1 protease 2107
reverse transcriptase 220
pepsin 31
renin 25
RNase H 23
trypsin 20
thrombin 19
ACS 19
P-glycoprotein 17
cathepsin D 15
dihydrofolate reductase 15
MDR 12
RNA polymerase 10
neuraminidase 9
CYP3A4 9
beta-galactosidase 9
lysozyme 9
transcriptase 8
protein kinase 8
glutathione S-transferase 7
RNase 7
elastase 6
subtilisin 6
endothiapepsin 6
ERK 6
RNase 6
DNA polymerase 6
chymotrypsin 5
thromboplastin 5
proteasome 5
endonuclease 5
ATPase 5
ribonuclease 5
ribonuclease 5
thymidylate synthase 4
focal adhesion kinase 4
beta-secretase 4
plasmepsin II 4
acetylcholinesterase 3
luciferase 3
papain 3
thymidine kinase 3
rhizopuspepsin 3
caspase-3 3
peroxidase 3
ricin 3
lipase 3
protein kinase C 3
phenylalanine hydroxylase 2
2A protease 2
carbonic anhydrase 2
galactokinase 2
adenosine kinase 2
superoxide dismutase 2
chymase 2
glyceraldehyde-3-phosphate dehydrogenase 2
sulfatase 2
glyceraldehyde-3-phosphate dehydrogenase 2
PARP 2
thermolysin 2
cathepsin K 2
glyceraldehyde-3-phosphate dehydrogenase 2
plasmin 2
carboxypeptidase A 2
adenylate kinase 2
creatine kinase 2
tryptophan synthase 2
gastricsin 2
glyceraldehyde-3-phosphate dehydrogenase 2
cathepsin G 2
MMP 2
tryptase 2
glyceraldehyde-3-phosphate dehydrogenase 2
ACE 2
hydroxynitrile lyase 1
mitogen-activated protein kinase 1
nepenthesin 1
mu-calpain 1
coronavirus main proteinase 1
PRE 1
more...
Compound
hydrogen 231
Dec 145
water 134
Asp 82
Phe 75
DNA 67
urea 65
Ile 58
alanine 58
leucine 51
tyrosine 46
Clin 42
arginine 41
oxygen 38
aspartic acid 31
Gly 31
nitrogen 30
threonine 30
NH2 29
aspartic acid 29
aspartic acid 29
aspartic acid 29
THF 27
Ritonavir 26
cysteine 26
hydroxyethylamine 25
salt 23
lysine 23
His 22
methionine 22
KNI-272 21
valine 21
Amprenavir 21
THF 20
AZT 19
ACS 19
Indinavir 19
ACS 19
serine 18
tryptophan 17
proline 17
Nelfinavir 17
PDB 15
methanol 13
Lopinavir 13
MDR 12
SDS 11
glucose 11
sodium 11
calcium 10
MTT 10
TMC 10
zinc 9
COS 9
acetate 9
tryptophan 9
phosphate 9
tryptophan 9
acetonitrile 9
tryptophan 9
isoleucine 8
isoleucine 8
pyrrolidine 7
PEG 7
pyrrolidine 7
PNU 7
glutamic acid 7
sulfate 7
sulfamide 7
sulfamide 7
acetic acid 7
HCl 6
guanidine 6
benzamide 6
asparagine 6
naphthalene 5
pyridine 5
benzene 5
fluorine 5
ammonium 5
more...