Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.16 (HIV-1 protease)
 2,107 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 169
protease inhibitor 163
Mol 143
Gag 132
NMR 94
gag 83
Pol 81
P2' 71
dimeric 68
pol 57
CD4 51
integrase 45
p24 38
polypeptide 26
MT-4 26
fused 25
SOD 25
renin 25
aspartyl protease 24
Gag polyprotein 23
p66 21
RNase H 20
SAR 20
thrombin 20
GRL 19
ACS 19
cytochrome P450 18
p51 18
hinge 18
insulin 18
P-glycoprotein 17
cathepsin D 16
Boc 16
p17 16
PDB 15
NL4 15
Met 14
dihydrofolate reductase 13
gem 13
MT-2 12
p24 antigen 12
p55 12
precursor protein 11
SDS 11
glycoprotein 11
TMC 10
lysozyme 9
neuraminidase 9
CYP3A4 9
serum albumin 9
vimentin 8
non-active 8
HINT 8
Gag protein 8
Nle 8
SARS 8
EPR 8
env 7
cytokine 7
F11 7
matrix protein 7
cage 7
CCR5 7
MDR1 6
lymphoid 6
BACE1 6
crystallin 6
tRNA 6
Gen 6
ROD 6
serine protease 6
SP1 6
p15 6
kit 6
Leu5 5
Env 5
matrix metalloproteinase 5
MRP 5
HLA 5
CHA 5
threonine 5
factor Xa 5
chimeric protein 5
proteasome 5
CDK2 5
endonuclease 5
hemoglobin 5
SIV 5
DNA polymerase 5
Pseudomonas 4
DHFR 4
P-gp 4
p66 RT 4
ribonuclease A 4
serum protein 4
microsomal 4
ESI 4
C18 4
ATP 4
ACH 4
envelope protein 4
MP2 4
CXCR4 4
envelope glycoprotein 4
transferrin receptor 4
TNF-alpha 4
estrogen receptor 4
P450 4
PR1 4
chymotrypsin-like 4
CD8 4
ezrin 4
thymidylate synthase 4
ras 4
16a 4
caspase-3 3
cytochrome 3
ATPase 3
glutathione S-transferase 3
ATP-binding cassette 3
cyclophilin A 3
STD 3
CPU 3
THP 3
IL-6 3
IL-2 3
albumin 3
lactoferrin 3
P51 3
core protein 3
BACE 3
interleukin-6 3
gag protein 3
C-terminal peptide 3
MT2 3
thioredoxin 3
transferrin 3
Env protein 3
asymmetrical 3
GSH 3
Fas 3
PLS 3
desmin 3
calmodulin 3
PMS 3
SP2 3
GST 3
caspase-8 3
lipase 3
chymotrypsin 3
carbonic anhydrase II 3
all-trans 3
CYP3A 3
Sta 3
HERV-K 3
cryptic 3
interferon 3
casein 3
GRID 3
thymidine kinase 3
Ang II 3
FKBP12 3
cyclin-dependent kinase 2 3
TOF 3
nitric oxide synthase 3
ATV 3
cyclin-dependent kinase 2
MIP-1alpha 2
steroid sulfatase (STS) 2
acetylcholinesterase 2
H17 2
hole 2
histone deacetylase 2
lipopolysaccharide 2
heavy chain 2
chymase 2
cathepsin G 2
androgen receptor 2
heat shock protein 90 2
gastricsin 2
BID 2
ubiquitin 2
p10 2
trypsin inhibitor 2
P50 2
superoxide dismutase 2
metalloproteinase 2
carbonic anhydrase 2
MRP-1 2
glyceraldehyde-3-phosphate dehydrogenase 2
STAT3 2
mer 2
MAP-2 2
p25 2
protein tyrosine phosphatase 2
p38 MAP kinase 2
ABCC1 2
beta 1 2
RPMI 2
filamin 2
metalloprotease 2
Cyclophilin A 2
FK506 2
SMD 2
aromatase 2
p24) 2
MMP-9 2
amyloid precursor protein 2
eIF4GII 2
DSC 2
CIC 2
phenylalanine hydroxylase 2
CD57 2
PEG 2
talin 2
lectin 2
p53 2
troponin C 2
p68 2
CFTR 2
nuclear protein 2
5-hydroxytryptamine 2
vascular endothelial growth factor 2
58kDa 2
bcl-2 2
TEM 2
cysteine protease 2
single-chain Fv fragment 2
PABP 2
P36 2
CYP 2
P12 2
type I interferon 2
BF2 2
somatostatin 2
tropomyosin 2
angiogenin 2
beta-globin 2
adenylate kinase 2
Cytochrome P450 2
ALA 2
adenosine kinase 2
K10 2
ferritin 2
inhibitor 2 2
TFP 2
reserved 2
ORF 2
MMP 2
sulfatase 2
enigma 2
APA 2
RPI 2
eukaryotic translation initiation factor 2
galactokinase 2
p58 2
ABCG2 2
cytochrome P-450 2
deoxyribonuclease 2
CYP2D6 2
BCRP 2
Proteinase 2
DUET 2
PC-3 2
17beta-hydroxysteroid dehydrogenase 2
adenosine triphosphatase 2
poly(A)-binding protein 2
scFv 2
mast cell 2
INS-1 2
RANTES 2
ACT 2
cathepsin K 2
chemokine 2
human leukocyte antigen 2
peroxisome proliferator activated receptor 1
p57 1
PPAR 1
KIR 1
annexin V 1
LDH 1
IRS-2 1
P38 1
CRABP 1
stromelysin 1
protein S 1
fur 1
glutathione peroxidase 4 1
COX2 1
Hua 1
SYM 1
granzyme B 1
memapsin 2 1
Bak 1
cofilin 1
OASIS 1
CD40 1
neurotrophin 1
ABC-transporter 1
RPR 1
CYP2B6 1
major histocompatibility complex class I 1
ICMT 1
p65 1
calcium channel 1
ADP-ribosyltransferase 1
translation initiation factor 1
p41 1
L-asparaginase 1
CSP 1
glutathione reductase 1
IFN-beta 1
DNA-dependent DNA polymerase 1
HXB 1
histone 1
L11 1
Bcl-2 1
PB1 1
IL-1 beta 1
CYP2C19 1
more...
Disease
HIV 1007
immunodeficiency 389
AIDS 292
Human immunodeficiency virus type 29
leukemia 27
cancer 24
SAR 20
lipodystrophy 16
tumor 15
PDB 15
virus infection 14
CEM 14
SARS 12
malaria 11
SDS 11
hepatitis C 10
Rous sarcoma 10
Alzheimer's disease 9
infectious diseases 9
Infection 9
viremia 9
candidiasis 7
influenza 7
hyperlipidemia 7
diabetes 6
fits 6
cytomegalovirus 6
West 5
stomatitis 5
encephalitis 5
Kaposi's sarcoma 5
dyslipidemia 5
hypertension 5
vaccinia 5
NS3 4
HTLV-I 4
Mycobacterium 4
cataract 4
STD 4
Dissociation 4
dementia 4
leishmaniasis 4
achondroplasia 4
glucose intolerance 4
myelopathy 4
SCID 3
myeloid leukemia 3
wasting 3
adult T-cell leukemia/lymphoma 3
tuberculosis 3
glioblastoma 3
latent infection 3
suicide 3
PLS 3
plaque 3
hepatitis B 3
GSH 3
HAM 3
avian influenza 2
myeloblastosis 2
subacute sclerosing panencephalitis 2
encephalomyelitis 2
cervical cancer 2
anemia 2
SMD 2
MCF 2
idiopathic thrombocytopenic purpura 2
renal disease 2
TEM 2
rash 2
TEM 2
substance use 2
Evans 2
sarcoma 2
thrombocytopenia 2
hypercholesterolemia 2
herpes 2
cardiovascular disease 2
herpes simplex 2
type 2 diabetes 2
prostate cancer 2
immune deficiency 2
hepatitis 2
breast cancer 2
Schistosoma japonicum 2
mammary tumor 2
mimicry 2
FTC 2
lipomatosis 2
HIV-2 infection 2
schizophrenia 1
cirrhosis 1
liver cancer 1
opportunistic infection 1
EDC 1
lymphocytic choriomeningitis 1
Graves' disease 1
generalized lipodystrophy 1
lymphoma 1
cocaine addiction 1
Parkinson's disease 1
adenocarcinoma 1
MVA 1
mouth disease 1
haemophilia 1
liver disease 1
lymphopenia 1
protozoan infection 1
Hodgkin's disease 1
hyperbilirubinemia 1
multiple myeloma 1
multiple sclerosis 1
Schistosoma mansoni 1
cholera 1
ORM1*S 1
retroviral disease 1
toxoplasmosis 1
ANM 1
CASTLE 1
tumor progression 1
SCH 1
CSA 1
chronic disease 1
Acute infection 1
Still 1
Haemophilia 1
oral candidiasis 1
arthritis 1
microsporidiosis 1
mitral valve prolapse 1
metabolic syndrome 1
fatty liver 1
HSS 1
carcinogenesis 1
Tic 1
cleft palate 1
hyperinsulinemia 1
hypercortisolism 1
Chronic hepatitis C 1
BED 1
abdominal obesity 1
gastroenteritis 1
kala-azar 1
leprosy 1
Roth 1
ACP 1
lipoatrophy 1
Enzyme inhibition 1
lung cancer 1
atherosclerosis 1
rabies 1
colorectal cancer 1
cold 1
avian sarcoma 1
renal insufficiency 1
Wells 1
peptic ulcer 1
HML 1
drug withdrawal 1
non-gonococcal urethritis 1
brain atrophy 1
CASTLE 1
syphilis 1
renal failure 1
Disorder 1
panniculitis 1
tumor growth 1
Junin 1
coronary heart disease 1
tic 1
Chagas 1
acute promyelocytic leukemia 1
cryoglobulinemia 1
AD8 1
Nairobi 1
cryptococcal meningitis 1
bilateral cataracts 1
PCP 1
carcinoma 1
MIP 1
neuroblastoma 1
Endothelial dysfunction 1
fibrosarcoma 1
Familial partial lipodystrophy 1
immunopathology 1
glomerulonephritis 1
diphtheria 1
bends 1
Cushing's syndrome 1
EIN 1
Infections 1
liver fibrosis 1
PHA 1
smallpox 1
pancreatitis 1
Fraser 1
drug abuse 1
dengue 1
meningioma 1
parkinsonism 1
Andersen 1
CNS diseases 1
tumorigenesis 1
alcohol abuse 1
grade I meningioma 1
addiction 1
coxsackievirus 1
liver cancer 1
CES 1
amyloidosis 1
Symptom
diarrhea 8
nausea 4
collapse 3
starvation 1
dyspnea 1
general problem 1
acidity 1
vomiting 1
angina 1
abdominal discomfort 1
asthenia 1
weakness 1
splenomegaly 1
Drug
Asn 40
Darunavir 32
ROC 23
THF 20
Indinavir 19
AZT 18
AZT 18
ATV 17
Biopolymers 14
TMC114 12
TPV 8
lysine 6
Monit 5
Crixivan 4
Crixivan 4
Crixivan 4
Fosamprenavir 4
Agenerase 3
IL-2 3
NLF 3
Fosamprenavir calcium 2
Norvir 2
Glide 2
Gel 2
Fragment 2
ACT 2
Alanine 2
Taxol 2
ddI 2
Cisapride 1
Acacia 1
Mutagen 1
Glycerol 1
Rosiglitazone 1
Prezista 1
caffeine 1
Kenyan 1
Maltose 1
Reverset 1
Etravirine 1
Trusopt 1
Lipidex 1
Glutathione 1
Onconase 1
CTX 1
G418 1
CPO 1
Gastro 1
Albumin 1
NVP 1
monobasic sodium phosphate 1
Sodium nitroprusside 1
Fluorescein 1
ABC 1
Rosuvastatin 1
Lexiva 1
Cardiovasc 1
Avobenzone 1
Trusopt 1
Invirase 1
Pepstatin 1
Dihydro 1
Tenofovir 1
Fluorescein 1
Viracept 1
Aztec 1
Compound 19 1
Leaf 1
Sulfamide 1
PMPA 1
Vitamin E 1
Ditekiren 1
Tacrolimus 1
PMEA 1
Epivir 1
Enzyme
HIV-1 protease 2107
reverse transcriptase 220
pepsin 31
renin 25
RNase H 23
trypsin 20
ACS 19
thrombin 19
P-glycoprotein 17
dihydrofolate reductase 15
cathepsin D 15
MDR 12
RNA polymerase 10
lysozyme 9
CYP3A4 9
neuraminidase 9
beta-galactosidase 9
protein kinase 8
transcriptase 8
glutathione S-transferase 7
RNase 7
subtilisin 6
DNA polymerase 6
elastase 6
ERK 6
RNase 6
endothiapepsin 6
proteasome 5
chymotrypsin 5
endonuclease 5
ribonuclease 5
thromboplastin 5
ATPase 5
ribonuclease 5
thymidylate synthase 4
beta-secretase 4
focal adhesion kinase 4
plasmepsin II 4
rhizopuspepsin 3
papain 3
luciferase 3
protein kinase C 3
peroxidase 3
lipase 3
acetylcholinesterase 3
thymidine kinase 3
ricin 3
caspase-3 3
galactokinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
2A protease 2
glyceraldehyde-3-phosphate dehydrogenase 2
gastricsin 2
tryptophan synthase 2
adenylate kinase 2
cathepsin K 2
tryptase 2
carboxypeptidase A 2
PARP 2
creatine kinase 2
plasmin 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
carbonic anhydrase 2
chymase 2
adenosine kinase 2
cathepsin G 2
glyceraldehyde-3-phosphate dehydrogenase 2
MMP 2
thermolysin 2
phenylalanine hydroxylase 2
superoxide dismutase 2
ACE 2
sulfatase 2
ADP-ribosyltransferase 1
hydroxynitrile lyase 1
soluble epoxide hydrolase 1
ADP-ribosyltransferase 1
coronavirus main proteinase 1
PRE 1
cytochrome c peroxidase 1
catalase 1
flavin-containing monooxygenase 1
insulin-degrading enzyme 1
MIP 1
m-calpain 1
AOR 1
lactate dehydrogenase 1
tryptophan 2,3-dioxygenase 1
xylose isomerase 1
urease 1
MPP 1
alpha-glucosidase 1
penicillopepsin 1
neutrophil elastase 1
aminopeptidase P 1
DNase 1
NQO1 1
lysyl-tRNA synthetase 1
cathepsin L 1
pyruvate carboxylase 1
3C protease 1
heparinase 1
alanine aminotransferase 1
benzoylformate decarboxylase 1
prolidase 1
chloramphenicol acetyltransferase 1
enolase 1
deoxyribonuclease 1
deoxyribonuclease 1
MEK 1
SMP 1
xylanase 1
glucose oxidase 1
amylomaltase 1
pectin methylesterase 1
enoyl-ACP reductase 1
hydroxynitrile lyase 1
protein farnesyltransferase 1
topoisomerase 1
chymosin 1
asparaginase 1
topoisomerase 1
mitogen-activated protein kinase 1
nepenthesin 1
memapsin 2 1
NMT 1
xylanase 1
KLK13 1
cytosine deaminase 1
mu-calpain 1
GSK 1
cholinesterase 1
prolyl endopeptidase 1
enzyme X 1
APC 1
urease 1
urokinase-type plasminogen activator 1
eEF2 kinase 1
furin 1
dipeptidyl peptidase IV 1
cruzipain 1
micrococcal nuclease 1
toluene dioxygenase 1
lipoprotein lipase 1
cathepsin B 1
TSA 1
CD10 1
glutathione reductase 1
granzyme B 1
CDR 1
aequorin 1
cdc2 1
hexokinase 1
factor C 1
hydroxynitrile lyase 1
ribonucleotide reductase 1
MMP-3 1
SPC 1
tryptophanase 1
ribonucleotide reductase 1
guanylate cyclase 1
legumain 1
tyrosinase 1
protein N-myristoyltransferase 1
collagenase 1
dihydrodipicolinate reductase 1
enoyl-ACP reductase 1
protease do 1
Compound
hydrogen 231
Dec 145
water 134
Asp 82
Phe 75
DNA 67
urea 65
alanine 58
Ile 58
leucine 51
tyrosine 46
Clin 42
arginine 41
oxygen 38
Gly 31
aspartic acid 31
threonine 30
nitrogen 30
aspartic acid 29
aspartic acid 29
NH2 29
aspartic acid 29
THF 27
cysteine 26
Ritonavir 26
hydroxyethylamine 25
lysine 23
salt 23
His 22
methionine 22
KNI-272 21
Amprenavir 21
valine 21
THF 20
Indinavir 19
AZT 19
ACS 19
ACS 19
serine 18
Nelfinavir 17
proline 17
tryptophan 17
PDB 15
methanol 13
Lopinavir 13
MDR 12
glucose 11
sodium 11
SDS 11
calcium 10
MTT 10
TMC 10
acetonitrile 9
phosphate 9
tryptophan 9
acetate 9
COS 9
tryptophan 9
zinc 9
tryptophan 9
isoleucine 8
isoleucine 8
PNU 7
pyrrolidine 7
sulfamide 7
acetic acid 7
PEG 7
sulfate 7
sulfamide 7
pyrrolidine 7
glutamic acid 7
HCl 6
guanidine 6
asparagine 6
benzamide 6
ammonium 5
nitric oxide 5
ethanol 5
Pepstatin 5
naphthalene 5
benzene 5
PEG 5
fluorine 5
pyridine 5
glycerol 5
His-Leu 4
galactose 4
ATP 4
EDTA 4
retinoic acid 4
GSH 4
potassium 4
hydrazine 4
quinoline 4
isopropanol 4
ethyl acetate 4
iodine 4
GSH 4
quinoline 4
DMSO 4
EDTA 4
xylose 3
glutamate 3
3TC 3
hydroxide 3
acetamide 3
BAL 3
THP 3
Optimal 3
DMP 3
TOF 3
sodium chloride 3
phosphoric acid 3
phenol 3
DMP 3
pinacol 3
Nevirapine 3
DMP 3
DMF 3
piperidine 3
5-phenylpentanoic acid 3
acrylamide 3
DMP 3
APV 3
piperidine 3
acetamide 3
aniline 3
ACM 3
diacetate 3
copper 3
vinyl 3
FK506 3
THP 3
2-pyrrolidinone 2
Abbott 2
MSM 2
A 99 2
morpholine 2
5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 2
LPC 2
2-pyrrolidinone 2
hydroquinone 2
hydroxylamine 2
succinic acid 2
Oleanolic acid 2
gallic acid 2
ANS 2
Nelfinavir mesylate 2
ANS 2
Triton X-100 2
Haloperidol 2
ammonia 2
succinic acid 2
Pac 2
2-phenylquinoline 2
succinic acid 2
Efavirenz 2
Insulin 2
aldehyde 2
Alanine 2
succinic acid 2
iron 2
Haloperidol 2
norleucine 2
phenylboronic acid 2
bromide 2
Mg2+ 2
nicotinamide 2
TEM 2
Mato 2
H2O2 2
TAR 2
decahydroisoquinoline 2
aldehyde 2
hydroxylamine 2
cyclopentyl 2
norleucine 2
Glu-Glu 2
chlorine 2
succinic acid 2
Amaranthin 2
2-hydroxy-4-phenylbutanoic acid 2
aminomethyl 2
glutamine 2
dicarboxylic acid 2
d4T 2
2,5-dihydroxybenzoic acid 1
Quercetin 1
Molybdenum hexacarbonyl 1
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 1
A 1 1
Cisapride 1
isoquinoline 1
MBC 1
cyclopentanone 1
CES 1
formic acid 1
PHE 1
GMP 1
phthalic acid 1
Sodium 1
formic acid 1
SO2 1
2,6-dimethoxybenzoic acid 1
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 1
MIC 1
C8H8O5 1
1,4-dioxane 1
Betulinic acid 1
benzoic acid 1
ITP 1
methanesulfonic acid 1
Epigallocatechin gallate 1
cyclopentanone 1
P 2 1
Glyoxylate 1
PCM 1
dimethyl malonate 1
1H-indene 1
Carbenicillin 1
EPNP 1
PAM 1
dUTP 1
1,1'-biphenyl 1
C5H11NO2 1
Wellcome 1
AET 1
CPA 1
C-3 1
2,2-dichloroacetamide 1
toluene 1
cyclohexanone 1
Coumarin 1
Limonin 1
cyclohexanone 1
C8H8O5 1
4-phenylbutanoic acid 1
kaempferol 1
PMEA 1
CAT 1
formic acid 1
cyclohexanone 1
CAT 1
methanesulfonic acid 1
carbonate 1
phenanthridine 1
formic acid 1
Maltose 1
Emodin 1
methanesulfonic acid 1
MPTP 1
cGMP 1
Fisetin 1
Molybdenum hexacarbonyl 1
C8H8O5 1
C8H8O5 1
Proline 1
SDZ PSC 833 1
formic acid 1
methyl carbamate 1
butyric acid 1
pyrene 1
CPA 1
SCC 1
1,5-dibromopentane 1
dodecane 1
phenanthridine 1
Luteolin 1
CPA 1
methane 1
Paclitaxel 1
Curcumin 1
cyclohexanone 1
chalcone 1
Valproic acid 1
Gold, 1
formic acid 1
methanethiol 1
benzenesulfonamide 1
cinnamyl 1
Biotin 1
2-butenyl 1
1-methyl-1H-imidazole 1
maslinic acid 1
butyric acid 1
CPP 1
chloroform 1
indane 1
myristic acid 1
Thrombin 1
Limonin 1
ACTH 1
Vitamin D 1
Casein 1
dichloromethane 1
BMC 1
formic acid 1
CTX 1
Isoscutellarein 1
TNF 1
A 3 1
1-indanone 1
3-hydroxybenzamide 1
Cortisol 1
myricetin 1
C8H8O5 1
GSSG 1
C8H8O5 1
NTA 1
Pluronic 1
cyclohexanone 1
DPPH 1
EDC 1
undecane 1
DEAE 1
TCA 1
cyclohexanone 1
3-aminobenzamide 1
C8H8O5 1
cyanide 1
more...