Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.16 (HIV-1 protease)
 2,107 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
GRL 11.5
BCA3 11.3
p66 RT 11.2
P2' 10.9
Gag polyprotein 9.8
PPP1R15B 9.7
ICMT 9.6
SERINC3 9.5
DUET 9.4
DDI1 9.3
eIF4GII 9.3
p15 protein 9.2
NDR2 9.1
58kDa 9.1
P51 8.9
p66 8.8
aspartyl protease 8.8
Gag 8.8
pol protein 8.7
HINT 8.7
NL4 8.6
ALP1 8.6
ROD 8.5
human leucocyte antigen D 8.4
SERINC5 8.4
ATV 8.4
MT-4 8.3
myristoyl-CoA:protein N-myristoyltransferase 8.3
RCE1 8.3
protease inhibitor 8.3
single-chain Fv fragment 8.2
LIM1 8.1
gastricsin 8.1
HDJ-2 8.1
TMC 7.8
MRP-1 7.8
gag 7.7
p51 7.7
DNA replication licensing factor 7.7
H17 7.7
ANM 7.7
APOBEC3H 7.7
RPI 7.6
P36 7.5
PABP1 7.5
TLF 7.5
HXB 7.4
p17 7.4
Gag protein 7.4
P66 7.3
MAP-1 7.3
F11 7.3
TGD 7.3
gag protein 7.3
p24 7.3
alpha S1-casein 7.3
TE2 7.2
Nle 7.2
Sta 7.2
metallocarboxypeptidase 7.2
MT-2 7.2
PINCH 7.1
gem 7.1
HERV-K 7.1
V75 7.1
FK-506 binding protein 7.1
ZMPSTE24 7.0
pol 7.0
preadipocyte factor 7.0
LTK 7.0
integrase 7.0
RNase H 6.9
HPC1 6.9
RNH 6.9
ARTEMIS 6.9
steroid sulfatase (STS) 6.9
NDR1 6.8
ACH 6.8
non-active 6.8
D29 6.7
Env protein 6.7
CD4 protein 6.7
PEG3 6.7
TAPS 6.7
diubiquitin 6.6
TFP 6.6
SYM 6.6
PP5 6.6
P37 6.5
p55 6.5
p24 antigen 6.5
16a 6.5
human leukocyte antigen class I 6.4
NMT 6.4
Cyclophilin A 6.3
DNA-dependent DNA polymerase 6.3
PR1 6.3
HEB 6.3
GRID 6.2
N14 6.2
p68 6.2
PABP 6.2
A27 6.1
p58 6.1
BEST 6.1
carboxyl methyltransferase 6.1
alphaA-crystallin 6.1
AG1 6.1
CLB 6.1
p24) 6.0
ABC-transporter 6.0
memapsin 2 6.0
IMPDH 6.0
BACE 6.0
DHFR 6.0
MRP 6.0
PEG10 6.0
ILK 5.9
aminopeptidase P 5.9
CHA 5.9
p41 5.9
CRABP 5.8
ACTG 5.8
lysyl-tRNA synthetase 5.8
BF2 5.8
Breast Cancer Resistance Protein 5.8
Leu5 5.8
cathepsin E 5.7
cathepsin D 5.7
A3 adenosine receptor 5.7
cyclin-dependent kinase 2 5.7
17beta-hydroxysteroid dehydrogenase 5.7
MAP-2 5.7
legumain 5.7
cyclophilin A 5.7
SP3 5.6
CIC 5.6
galactokinase 5.6
FKBP12 5.6
HDX 5.6
ABCE1 5.6
RPR 5.6
CLN 5.5
HEX 5.5
Cdc48 5.5
SP2 5.5
L23 5.5
poly(A)-binding protein 5.5
P45 5.5
CD66b 5.5
PDB 5.5
P23 5.4
TRK 5.4
P42 5.4
SP1 5.4
p27kip1 5.4
dimeric 5.4
prolyl endopeptidase 5.4
HR1 5.4
AGL 5.4
more...
Disease
ORM1*S 10.1
CASTLE 9.0
Familial partial lipodystrophy 9.0
CASTLE 8.5
grade I meningioma 8.4
Human immunodeficiency virus type 8.2
ANM 7.7
AD8 7.5
EIN 7.1
lipodystrophy 6.8
retroviral disease 6.6
HIV 6.5
HIV-2 infection 6.4
immunodeficiency 6.4
Acute infection 6.0
Enzyme inhibition 5.9
bilateral cataracts 5.7
CEM 5.7
Rous sarcoma 5.6
BED 5.6
generalized lipodystrophy 5.5
achondroplasia 5.4
protozoan infection 5.4
SAR 5.3
AIDS 5.2
non-gonococcal urethritis 5.2
PDB 5.1
microsporidiosis 5.0
Junin 5.0
myeloblastosis 4.9
HML 4.9
SMD 4.8
lipomatosis 4.7
MVA 4.7
HTLV-I 4.6
FTC 4.6
Tic 4.4
lipoatrophy 4.4
avian sarcoma 4.2
adult T-cell leukemia/lymphoma 4.1
NS3 4.1
Chronic hepatitis C 4.1
HAM 4.1
Dissociation 4.0
Fraser 4.0
PLS 3.9
subacute sclerosing panencephalitis 3.9
Roth 3.8
Schistosoma japonicum 3.8
latent infection 3.8
viremia 3.7
cocaine addiction 3.7
candidiasis 3.7
Nairobi 3.5
myeloid leukemia 3.5
cryptococcal meningitis 3.4
CES 3.4
HSS 3.4
SARS 3.2
Wells 3.2
panniculitis 3.2
CSA 3.2
EDC 3.1
cryoglobulinemia 3.1
Kaposi's sarcoma 3.1
stomatitis 3.1
immune deficiency 3.0
Endothelial dysfunction 3.0
Andersen 3.0
oral candidiasis 3.0
kala-azar 2.8
vaccinia 2.8
hypercortisolism 2.8
hyperlipidemia 2.7
drug withdrawal 2.7
CNS diseases 2.6
wasting 2.5
dyslipidemia 2.4
coxsackievirus 2.4
abdominal obesity 2.4
mimicry 2.4
mitral valve prolapse 2.4
ACP 2.4
glucose intolerance 2.4
lymphocytic choriomeningitis 2.3
tic 2.3
leishmaniasis 2.2
mammary tumor 2.2
smallpox 2.2
idiopathic thrombocytopenic purpura 2.2
hepatitis C 2.2
leukemia 2.1
virus infection 2.1
myelopathy 2.1
STD 2.1
opportunistic infection 2.1
bends 2.1
SCID 2.0
encephalitis 2.0
hyperbilirubinemia 2.0
immunopathology 1.9
avian influenza 1.9
mouth disease 1.9
malaria 1.9
Infection 1.8
herpes 1.8
SDS 1.7
Cushing's syndrome 1.7
cytomegalovirus 1.7
Disorder 1.6
lymphopenia 1.6
brain atrophy 1.6
SCH 1.6
MIP 1.6
fits 1.5
Evans 1.3
glioblastoma 1.3
encephalomyelitis 1.2
PCP 1.1
toxoplasmosis 1.1
Schistosoma mansoni 1.1
substance use 1.1
cataract 1.1
diphtheria 1.0
fibrosarcoma 1.0
hypercholesterolemia 1.0
rabies 1.0
acute promyelocytic leukemia 0.9
influenza 0.9
rash 0.9
liver fibrosis 0.9
Infections 0.9
meningioma 0.9
peptic ulcer 0.9
Chagas 0.8
syphilis 0.8
Haemophilia 0.8
PHA 0.8
Still 0.8
Graves' disease 0.7
suicide 0.7
infectious diseases 0.7
renal insufficiency 0.7
drug abuse 0.7
leprosy 0.5
TEM 0.5
cleft palate 0.5
hyperinsulinemia 0.5
TEM 0.5
haemophilia 0.5
cervical cancer 0.4
gastroenteritis 0.4
alcohol abuse 0.4
liver cancer 0.4
amyloidosis 0.3
Alzheimer's disease 0.3
GSH 0.3
hepatitis B 0.2
sarcoma 0.2
Mycobacterium 0.2
more...
Symptom
general problem 4.1
abdominal discomfort 3.1
asthenia 2.5
nausea 1.4
diarrhea 1.1
collapse 0.7
splenomegaly 0.6
acidity -0.0
angina -0.5
starvation -0.7
dyspnea -0.9
vomiting -1.1
weakness -1.3
Drug
Ditekiren 12.3
TMC114 12.0
Darunavir 11.7
Fosamprenavir 11.6
Prezista 11.3
Lexiva 11.3
Fosamprenavir calcium 11.2
Reverset 10.9
Agenerase 10.3
Indinavir 10.2
TPV 10.0
Sulfamide 9.8
ATV 9.4
Trusopt 9.4
Crixivan 9.2
Avobenzone 9.2
Crixivan 9.2
Trusopt 9.1
Crixivan 9.0
monobasic sodium phosphate 8.8
Invirase 8.4
NLF 8.2
Viracept 7.8
Norvir 7.7
Etravirine 7.4
Compound 19 7.4
Epivir 7.4
Onconase 7.1
Pepstatin 6.9
AZT 6.7
AZT 6.5
Lipidex 6.3
Aztec 6.1
ddI 6.1
Asn 5.7
CPO 5.6
Glide 5.6
ROC 5.5
Cisapride 5.5
THF 5.2
Tenofovir 5.2
Rosuvastatin 5.1
Maltose 5.0
Dihydro 4.9
Biopolymers 4.6
PMEA 4.4
PMPA 4.3
Rosiglitazone 4.2
Gastro 4.1
NVP 4.0
Sodium nitroprusside 3.9
ACT 3.8
Fragment 3.7
Alanine 3.4
Taxol 3.2
Acacia 3.2
Tacrolimus 3.2
G418 2.8
Glycerol 2.7
Fluorescein 2.5
Vitamin E 2.2
Kenyan 2.1
Fluorescein 2.0
Albumin 1.7
Glutathione 1.5
Mutagen 1.3
Monit 1.1
Gel 1.0
ABC 0.8
IL-2 0.6
lysine 0.6
CTX 0.6
caffeine -0.5
Leaf -0.5
Cardiovasc -3.7
Enzyme
HIV-1 protease 13.9
protease do 12.3
coronavirus main proteinase 10.2
rhizopuspepsin 10.0
endothiapepsin 10.0
plasmepsin II 9.4
nepenthesin 8.6
memapsin 2 8.5
protein N-myristoyltransferase 8.4
gastricsin 8.3
dihydrodipicolinate reductase 8.3
KLK13 8.1
enzyme X 8.0
benzoylformate decarboxylase 7.5
2A protease 7.0
RNase H 7.0
penicillopepsin 6.9
hydroxynitrile lyase 6.9
hydroxynitrile lyase 6.8
reverse transcriptase 6.7
toluene dioxygenase 6.7
hydroxynitrile lyase 6.7
NMT 6.5
enoyl-ACP reductase 6.5
enoyl-ACP reductase 6.5
amylomaltase 6.2
aminopeptidase P 6.1
beta-secretase 6.1
eEF2 kinase 6.0
lysyl-tRNA synthetase 5.8
cathepsin D 5.8
pepsin 5.8
protein farnesyltransferase 5.6
galactokinase 5.6
tryptophan synthase 5.5
tryptophanase 5.4
MDR 5.4
dihydrofolate reductase 5.3
legumain 5.3
xylose isomerase 5.2
cruzipain 5.1
adenosine kinase 5.0
chymosin 5.0
3C protease 4.9
carboxypeptidase A 4.9
prolidase 4.9
factor C 4.6
chymase 4.5
SMP 4.5
mu-calpain 4.5
cytochrome c peroxidase 4.4
phenylalanine hydroxylase 4.4
CYP3A4 4.4
pectin methylesterase 4.4
subtilisin 4.4
insulin-degrading enzyme 4.4
cytosine deaminase 4.3
P-glycoprotein 4.3
prolyl endopeptidase 4.3
m-calpain 4.2
tryptophan 2,3-dioxygenase 4.1
thymidylate synthase 4.1
cathepsin G 4.1
cathepsin K 4.0
thermolysin 4.0
adenylate kinase 4.0
ADP-ribosyltransferase 3.9
ADP-ribosyltransferase 3.8
ricin 3.8
flavin-containing monooxygenase 3.8
transcriptase 3.7
TSA 3.6
heparinase 3.6
ribonuclease 3.5
ribonuclease 3.5
tryptase 3.4
renin 3.4
aequorin 3.4
deoxyribonuclease 3.4
pyruvate carboxylase 3.3
elastase 3.3
deoxyribonuclease 3.3
sulfatase 3.2
neuraminidase 3.2
beta-galactosidase 3.2
dipeptidyl peptidase IV 3.2
thrombin 3.1
AOR 3.1
MPP 3.0
PRE 3.0
cathepsin L 2.9
trypsin 2.8
MMP 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
chymotrypsin 2.8
papain 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.8
soluble epoxide hydrolase 2.8
glyceraldehyde-3-phosphate dehydrogenase 2.7
lysozyme 2.7
CDR 2.6
thymidine kinase 2.6
RNase 2.6
SPC 2.5
thromboplastin 2.5
asparaginase 2.5
RNase 2.5
glyceraldehyde-3-phosphate dehydrogenase 2.4
micrococcal nuclease 2.4
DNA polymerase 2.4
ribonucleotide reductase 2.4
ribonucleotide reductase 2.3
furin 2.2
glutathione S-transferase 2.2
glyceraldehyde-3-phosphate dehydrogenase 2.2
granzyme B 2.2
MMP-3 2.1
RNA polymerase 2.1
enolase 2.0
endonuclease 2.0
carbonic anhydrase 2.0
neutrophil elastase 1.9
ACS 1.9
cathepsin B 1.9
alpha-glucosidase 1.8
xylanase 1.8
xylanase 1.8
plasmin 1.7
MIP 1.6
chloramphenicol acetyltransferase 1.6
hexokinase 1.5
glucose oxidase 1.5
proteasome 1.4
NQO1 1.3
lipase 1.3
GSK 1.2
PARP 1.2
lipoprotein lipase 1.1
urease 1.1
urease 1.0
DNase 1.0
cdc2 0.9
guanylate cyclase 0.8
tyrosinase 0.7
ACE 0.7
topoisomerase 0.7
creatine kinase 0.7
acetylcholinesterase 0.7
glutathione reductase 0.7
CD10 0.6
topoisomerase 0.6
protein kinase 0.6
urokinase-type plasminogen activator 0.5
focal adhesion kinase 0.5
caspase-3 0.3
cholinesterase 0.3
luciferase 0.2
ATPase 0.2
ERK -0.1
APC -0.1
more...
Compound
5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 12.9
KNI-272 12.6
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 12.3
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 12.3
Amprenavir 11.9
Molybdenum hexacarbonyl 11.9
Molybdenum hexacarbonyl 11.9
Molybdenum hexacarbonyl 11.9
C8H8O5 11.6
C8H8O5 11.6
C8H8O5 11.6
C8H8O5 11.6
C8H8O5 11.6
C8H8O5 11.6
C8H8O5 11.6
Isoscutellarein 11.3
C5H11NO2 11.3
C8H8O5 11.3
C8H8O5 11.3
Nelfinavir mesylate 11.3
C8H8O5 11.1
C8H8O5 11.1
methyl 3,4,5-trihydroxybenzoate 10.9
2-hydroxy-4-phenylbutanoic acid 10.8
5-phenylpentanoic acid 10.8
2,6-dimethoxybenzoic acid 10.7
C8H8O5 10.7
hydroxyethylamine 10.7
Amaranthin 10.6
Nelfinavir 10.4
3-hydroxybenzamide 10.4
C8H8O5 10.4
1,5-dibromopentane 10.3
Indinavir 10.2
Ritonavir 9.9
Lopinavir 9.9
Tetraphenylporphyrin 9.6
decahydroisoquinoline 9.2
2,2-dichloroacetamide 9.0
3-hexanol 8.9
A 99 8.5
Limonin 8.5
sulfamide 8.4
Limonin 8.4
Limonin 8.4
sulfamide 8.4
Pepstatin 8.3
1-methyl-1H-imidazole 8.2
EPNP 8.2
2-phenylquinoline 8.1
TMC 7.8
4-phenylbutanoic acid 7.8
PNU 7.3
dimethyl malonate 7.1
hexanamide 7.1
Nevirapine 7.1
SDZ PSC 833 7.1
His-Leu 7.1
1-indanone 7.0
1-indanone 6.9
1H-indene 6.8
Carbenicillin 6.8
Cerulenin 6.8
2-pyrrolidinone 6.7
Carbenicillin 6.7
Oleanolic acid 6.6
Abacavir 6.6
AZT 6.5
2-imidazolidinone 6.5
methyl carbamate 6.5
Glucuronide 6.4
2-naphthoic acid 6.4
Efavirenz 6.4
P 2 6.4
Biliverdin 6.3
pinacol 6.2
Glyoxylate 6.1
2-pyrrolidinone 6.1
Mangiferin 6.0
DMP 6.0
1H-pyrrole 6.0
1H-pyrrole 5.9
AET 5.9
PDB 5.9
DMP 5.9
Fisetin 5.9
DMP 5.9
maslinic acid 5.9
Glu-Glu 5.8
corrin 5.7
Betulinic acid 5.7
Chrysin 5.7
2-butenyl 5.6
01M 5.6
THF 5.6
Cisapride 5.5
indane 5.5
2-butenyl 5.5
methanesulfonic acid 5.4
methanesulfonic acid 5.4
methanesulfonic acid 5.4
methanesulfonic acid 5.4
aspartic acid 5.4
Ile 5.4
aspartic acid 5.4
methanesulfonic acid 5.3
aspartic acid 5.3
phenanthridine 5.3
phenanthridine 5.3
phenanthridine 5.3
Ursolic acid 5.3
Gold, 5.3
Gold, 5.3
Gold, 5.3
d4T 5.2
PHE 5.2
MDR 5.2
cyclopentanone 5.2
cyclopentanone 5.2
THF 5.2
cyclopentanone 5.1
Asp 5.1
norleucine 5.1
cyclopentanone 5.1
aspartic acid 5.1
Maltose 5.0
APV 5.0
PMEA 4.9
undecane 4.9
benzamide 4.9
MAE 4.9
3TC 4.8
phenylboronic acid 4.8
norleucine 4.8
dibenzyl 4.6
DMP 4.6
2,5-dihydroxybenzoic acid 4.6
cyclopentanone 4.6
Luteolin 4.5
Phe 4.5
valine 4.4
Mato 4.4
methanethiol 4.4
Apigenin 4.3
ethyl carbamate 4.3
pyrrolidine 4.3
Azole 4.2
pyrrolidine 4.2
benzenesulfonamide 4.2
benzenesulfonamide 4.2
benzenesulfonamide 4.2
2-naphthyl 4.1
hydrogen 4.1
LPC 4.1
morpholine 4.1
BAL 4.0
cyclopentyl 4.0
MVA 4.0
3-aminobenzamide 4.0
Coumarin 4.0
more...