Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.16 (HIV-1 protease)
 2,107 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 169
protease inhibitor 163
Mol 143
Gag 132
NMR 94
gag 83
Pol 81
P2' 71
dimeric 68
pol 57
CD4 51
integrase 45
p24 38
polypeptide 26
MT-4 26
renin 25
fused 25
SOD 25
aspartyl protease 24
Gag polyprotein 23
p66 21
RNase H 20
thrombin 20
SAR 20
GRL 19
ACS 19
p51 18
hinge 18
insulin 18
cytochrome P450 18
P-glycoprotein 17
cathepsin D 16
Boc 16
p17 16
NL4 15
PDB 15
Met 14
gem 13
dihydrofolate reductase 13
p55 12
MT-2 12
p24 antigen 12
SDS 11
precursor protein 11
glycoprotein 11
TMC 10
CYP3A4 9
lysozyme 9
neuraminidase 9
serum albumin 9
EPR 8
Nle 8
HINT 8
vimentin 8
non-active 8
SARS 8
Gag protein 8
CCR5 7
matrix protein 7
cytokine 7
F11 7
env 7
cage 7
p15 6
crystallin 6
MDR1 6
Gen 6
ROD 6
lymphoid 6
tRNA 6
BACE1 6
serine protease 6
SP1 6
kit 6
Env 5
matrix metalloproteinase 5
HLA 5
threonine 5
DNA polymerase 5
MRP 5
factor Xa 5
Leu5 5
SIV 5
chimeric protein 5
endonuclease 5
CDK2 5
hemoglobin 5
CHA 5
proteasome 5
PR1 4
16a 4
CD8 4
ribonuclease A 4
p66 RT 4
serum protein 4
ezrin 4
thymidylate synthase 4
chymotrypsin-like 4
Pseudomonas 4
ATP 4
ACH 4
ras 4
TNF-alpha 4
P-gp 4
MP2 4
transferrin receptor 4
estrogen receptor 4
CXCR4 4
envelope glycoprotein 4
envelope protein 4
DHFR 4
ESI 4
microsomal 4
C18 4
P450 4
cyclophilin A 3
lactoferrin 3
cytochrome 3
ATPase 3
casein 3
ATP-binding cassette 3
CPU 3
albumin 3
C-terminal peptide 3
core protein 3
FKBP12 3
glutathione S-transferase 3
interleukin-6 3
thioredoxin 3
cryptic 3
IL-6 3
asymmetrical 3
Sta 3
cyclin-dependent kinase 2 3
ATV 3
IL-2 3
gag protein 3
GSH 3
Fas 3
BACE 3
THP 3
Env protein 3
GST 3
transferrin 3
PLS 3
STD 3
P51 3
PMS 3
TOF 3
thymidine kinase 3
caspase-3 3
Ang II 3
interferon 3
HERV-K 3
CYP3A 3
chymotrypsin 3
SP2 3
lipase 3
caspase-8 3
carbonic anhydrase II 3
more...
Disease
HIV 1007
immunodeficiency 389
AIDS 292
Human immunodeficiency virus type 29
leukemia 27
cancer 24
SAR 20
lipodystrophy 16
tumor 15
PDB 15
CEM 14
virus infection 14
SARS 12
SDS 11
malaria 11
hepatitis C 10
Rous sarcoma 10
Infection 9
Alzheimer's disease 9
infectious diseases 9
viremia 9
influenza 7
candidiasis 7
hyperlipidemia 7
diabetes 6
fits 6
cytomegalovirus 6
stomatitis 5
Kaposi's sarcoma 5
encephalitis 5
hypertension 5
vaccinia 5
dyslipidemia 5
West 5
leishmaniasis 4
NS3 4
Dissociation 4
Mycobacterium 4
achondroplasia 4
cataract 4
glucose intolerance 4
STD 4
HTLV-I 4
myelopathy 4
dementia 4
GSH 3
adult T-cell leukemia/lymphoma 3
PLS 3
wasting 3
plaque 3
suicide 3
tuberculosis 3
glioblastoma 3
myeloid leukemia 3
latent infection 3
hepatitis B 3
SCID 3
HAM 3
TEM 2
FTC 2
avian influenza 2
HIV-2 infection 2
subacute sclerosing panencephalitis 2
encephalomyelitis 2
hypercholesterolemia 2
anemia 2
cervical cancer 2
type 2 diabetes 2
rash 2
Evans 2
mammary tumor 2
idiopathic thrombocytopenic purpura 2
mimicry 2
renal disease 2
lipomatosis 2
cardiovascular disease 2
TEM 2
substance use 2
SMD 2
myeloblastosis 2
sarcoma 2
prostate cancer 2
herpes simplex 2
herpes 2
immune deficiency 2
thrombocytopenia 2
breast cancer 2
Schistosoma japonicum 2
MCF 2
hepatitis 2
schizophrenia 1
cirrhosis 1
liver cancer 1
opportunistic infection 1
EDC 1
lymphocytic choriomeningitis 1
Graves' disease 1
generalized lipodystrophy 1
lymphoma 1
cocaine addiction 1
Parkinson's disease 1
adenocarcinoma 1
MVA 1
mouth disease 1
haemophilia 1
liver disease 1
lymphopenia 1
protozoan infection 1
Hodgkin's disease 1
hyperbilirubinemia 1
multiple myeloma 1
multiple sclerosis 1
Schistosoma mansoni 1
cholera 1
ORM1*S 1
retroviral disease 1
toxoplasmosis 1
ANM 1
CASTLE 1
peptic ulcer 1
drug withdrawal 1
Acute infection 1
CASTLE 1
oral candidiasis 1
coronary heart disease 1
hyperinsulinemia 1
hypercortisolism 1
cryptococcal meningitis 1
gastroenteritis 1
microsporidiosis 1
mitral valve prolapse 1
Enzyme inhibition 1
lung cancer 1
MIP 1
carcinoma 1
metabolic syndrome 1
fatty liver 1
HSS 1
carcinogenesis 1
bends 1
diphtheria 1
Wells 1
Fraser 1
Disorder 1
tumor growth 1
Roth 1
Chagas 1
tumorigenesis 1
cryoglobulinemia 1
AD8 1
bilateral cataracts 1
PCP 1
neuroblastoma 1
Endothelial dysfunction 1
fibrosarcoma 1
Familial partial lipodystrophy 1
immunopathology 1
glomerulonephritis 1
Cushing's syndrome 1
EIN 1
more...
Symptom
diarrhea 8
nausea 4
collapse 3
starvation 1
dyspnea 1
general problem 1
acidity 1
vomiting 1
angina 1
abdominal discomfort 1
asthenia 1
weakness 1
splenomegaly 1
Drug
Asn 40
Darunavir 32
ROC 23
THF 20
Indinavir 19
AZT 18
AZT 18
ATV 17
Biopolymers 14
TMC114 12
TPV 8
lysine 6
Monit 5
Crixivan 4
Crixivan 4
Crixivan 4
Fosamprenavir 4
Agenerase 3
IL-2 3
NLF 3
Fosamprenavir calcium 2
Norvir 2
Glide 2
Gel 2
Fragment 2
ACT 2
Alanine 2
Taxol 2
ddI 2
Cisapride 1
Acacia 1
Mutagen 1
Glycerol 1
Rosiglitazone 1
Prezista 1
caffeine 1
Kenyan 1
Maltose 1
Reverset 1
Etravirine 1
Trusopt 1
Lipidex 1
Glutathione 1
Onconase 1
CTX 1
G418 1
CPO 1
Gastro 1
Albumin 1
NVP 1
monobasic sodium phosphate 1
Sodium nitroprusside 1
Fluorescein 1
ABC 1
Rosuvastatin 1
Lexiva 1
Cardiovasc 1
Avobenzone 1
Trusopt 1
Invirase 1
Pepstatin 1
Dihydro 1
Tenofovir 1
Fluorescein 1
Viracept 1
Aztec 1
Compound 19 1
Leaf 1
Sulfamide 1
PMPA 1
Vitamin E 1
Ditekiren 1
Tacrolimus 1
PMEA 1
Epivir 1
Enzyme
HIV-1 protease 2107
reverse transcriptase 220
pepsin 31
renin 25
RNase H 23
trypsin 20
thrombin 19
ACS 19
P-glycoprotein 17
dihydrofolate reductase 15
cathepsin D 15
MDR 12
RNA polymerase 10
neuraminidase 9
beta-galactosidase 9
lysozyme 9
CYP3A4 9
protein kinase 8
transcriptase 8
RNase 7
glutathione S-transferase 7
ERK 6
RNase 6
DNA polymerase 6
subtilisin 6
elastase 6
endothiapepsin 6
ribonuclease 5
thromboplastin 5
chymotrypsin 5
endonuclease 5
proteasome 5
ATPase 5
ribonuclease 5
thymidylate synthase 4
beta-secretase 4
focal adhesion kinase 4
plasmepsin II 4
rhizopuspepsin 3
papain 3
caspase-3 3
thymidine kinase 3
luciferase 3
protein kinase C 3
lipase 3
acetylcholinesterase 3
peroxidase 3
ricin 3
superoxide dismutase 2
galactokinase 2
chymase 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
gastricsin 2
tryptophan synthase 2
cathepsin K 2
tryptase 2
adenylate kinase 2
carboxypeptidase A 2
creatine kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
PARP 2
plasmin 2
carbonic anhydrase 2
adenosine kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
cathepsin G 2
glyceraldehyde-3-phosphate dehydrogenase 2
MMP 2
thermolysin 2
2A protease 2
phenylalanine hydroxylase 2
ACE 2
sulfatase 2
ADP-ribosyltransferase 1
hydroxynitrile lyase 1
soluble epoxide hydrolase 1
ADP-ribosyltransferase 1
coronavirus main proteinase 1
PRE 1
cytochrome c peroxidase 1
catalase 1
flavin-containing monooxygenase 1
insulin-degrading enzyme 1
MIP 1
m-calpain 1
AOR 1
lactate dehydrogenase 1
tryptophan 2,3-dioxygenase 1
xylose isomerase 1
urease 1
MPP 1
alpha-glucosidase 1
penicillopepsin 1
neutrophil elastase 1
aminopeptidase P 1
DNase 1
NQO1 1
lysyl-tRNA synthetase 1
cathepsin L 1
alanine aminotransferase 1
guanylate cyclase 1
enolase 1
deoxyribonuclease 1
deoxyribonuclease 1
MEK 1
SMP 1
xylanase 1
glucose oxidase 1
amylomaltase 1
pectin methylesterase 1
enoyl-ACP reductase 1
hydroxynitrile lyase 1
protein farnesyltransferase 1
topoisomerase 1
chymosin 1
asparaginase 1
topoisomerase 1
memapsin 2 1
NMT 1
xylanase 1
KLK13 1
mitogen-activated protein kinase 1
enzyme X 1
APC 1
nepenthesin 1
urease 1
urokinase-type plasminogen activator 1
cytosine deaminase 1
mu-calpain 1
GSK 1
eEF2 kinase 1
furin 1
cholinesterase 1
prolyl endopeptidase 1
dipeptidyl peptidase IV 1
cruzipain 1
micrococcal nuclease 1
toluene dioxygenase 1
lipoprotein lipase 1
CD10 1
glutathione reductase 1
granzyme B 1
CDR 1
cathepsin B 1
TSA 1
aequorin 1
cdc2 1
hexokinase 1
factor C 1
hydroxynitrile lyase 1
ribonucleotide reductase 1
MMP-3 1
SPC 1
tryptophanase 1
ribonucleotide reductase 1
legumain 1
tyrosinase 1
protein N-myristoyltransferase 1
collagenase 1
more...
Compound
hydrogen 231
Dec 145
water 134
Asp 82
Phe 75
DNA 67
urea 65
alanine 58
Ile 58
leucine 51
tyrosine 46
Clin 42
arginine 41
oxygen 38
aspartic acid 31
Gly 31
threonine 30
nitrogen 30
aspartic acid 29
NH2 29
aspartic acid 29
aspartic acid 29
THF 27
cysteine 26
Ritonavir 26
hydroxyethylamine 25
lysine 23
salt 23
methionine 22
His 22
Amprenavir 21
valine 21
KNI-272 21
THF 20
Indinavir 19
ACS 19
AZT 19
ACS 19
serine 18
proline 17
Nelfinavir 17
tryptophan 17
PDB 15
methanol 13
Lopinavir 13
MDR 12
SDS 11
glucose 11
sodium 11
TMC 10
calcium 10
MTT 10
COS 9
acetonitrile 9
acetate 9
zinc 9
tryptophan 9
tryptophan 9
tryptophan 9
phosphate 9
isoleucine 8
isoleucine 8
sulfate 7
pyrrolidine 7
sulfamide 7
PNU 7
glutamic acid 7
pyrrolidine 7
sulfamide 7
acetic acid 7
PEG 7
asparagine 6
benzamide 6
guanidine 6
HCl 6
naphthalene 5
pyridine 5
fluorine 5
ethanol 5
glycerol 5
nitric oxide 5
Pepstatin 5
PEG 5
ammonium 5
benzene 5
EDTA 4
quinoline 4
quinoline 4
GSH 4
ATP 4
galactose 4
iodine 4
ethyl acetate 4
GSH 4
potassium 4
retinoic acid 4
EDTA 4
His-Leu 4
isopropanol 4
DMSO 4
hydrazine 4
ACM 3
aniline 3
FK506 3
TOF 3
phosphoric acid 3
phenol 3
sodium chloride 3
piperidine 3
BAL 3
THP 3
vinyl 3
Optimal 3
acetamide 3
xylose 3
DMP 3
copper 3
hydroxide 3
DMP 3
pinacol 3
DMF 3
3TC 3
Nevirapine 3
glutamate 3
DMP 3
APV 3
5-phenylpentanoic acid 3
DMP 3
acrylamide 3
diacetate 3
piperidine 3
acetamide 3
THP 3
2-pyrrolidinone 2
chlorine 2
gallic acid 2
hydroxylamine 2
succinic acid 2
ANS 2
glutamine 2
Pac 2
ammonia 2
Haloperidol 2
MSM 2
A 99 2
aldehyde 2
morpholine 2
Oleanolic acid 2
ANS 2
hydroquinone 2
2-pyrrolidinone 2
Abbott 2
aminomethyl 2
Glu-Glu 2
Triton X-100 2
succinic acid 2
Mato 2
2-phenylquinoline 2
Efavirenz 2
Insulin 2
more...