Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.16 (
HIV-1 protease
)
2,107
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have investigated the ability of
HIV-1 protease
to cleave human complement proteins of the classical complement pathway: C1q, C2 and C4 as well as the regulatory protein,
C1-inhibitor
. Purified complement proteins were incubated with recombinant
HIV-1 protease
in vitro and analyzed by SDS-PAGE and immunoblotting assay. The only cleavage site was found in N-terminal region of
C1-inhibitor
, and it was located between residues Leu-32 and Phe-33 as determined by amino acid sequence analysis of the 85 kDa proteolytic fragment after 12 Edman degradation cycles. The
HIV-1 protease
cleavage sites were not found in C1q, C2 and C4 protein.
HIV-1 protease
-susceptible site in N-terminal region of
C1-inhibitor
is very close to the cleavage sites of some other proteases that are able to induce N-terminal proteolysis of the protein.
...
PMID:Identification of HIV-1 protease cleavage site in human C1-inhibitor. 1532 85
