Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.16 (
HIV-1 protease
)
2,107
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Phytochemical investigation of extracts of the stems of
Hypoestes aristata
led to the isolation of nine lignans that included four known compounds, namely, hinokinin (
1
), savinin (
2
), medioresinol (
3
), and two cubebins (
8a
,
b
), three new butyrolactone lignans (
4
-
6
), and butyrolactol lignans
7a
-
c
. The structures of the new compounds were established using 1D and 2D NMR and HRESIMS data. The absolute configurations of the new lignans were determined from their
ECD
data and the Mosher's ester method. This is the first unequivocal assignment of the absolute configuration at C-7 and C-7' of 7- and 7'-hydroxybutyrolactone lignans. The compounds were screened for inhibition of an
HIV-1 protease
enzyme, and compounds
1
and
6
exhibited moderate activity in this regard.
...
PMID:Bioactive Lignans from
Hypoestes aristata
. 3278 79
