Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.16 (
HIV-1 protease
)
2,107
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
From a methanol extract of Artemisia caruifolia, which showed a moderate inhibitory activity on
HIV-1 protease
in a preliminary screening, N1,N5,
N10
-tri-p-coumaroylspermidine and three dicaffeoylquinic acids were isolated. The former compound was found to appreciably inhibit
HIV-1 protease
. Of related amides which were chemically synthesized, N1,N5,
N10
,N14-tetra-p-coumaroylspermine and N1,N4,N7,
N10
,N13-penta-p-coumaroylte-traethylenepentamine inhibited
HIV-1 protease
more potently than N1,N5,
N10
-tri-p-coumaroylspermidine.
...
PMID:Inhibitory effects on HIV-1 protease of tri-p-coumaroylspermidine from Artemisia caruifolia and related amides. 1145 3
