Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.15 (
renin
)
35,795
document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
renin
35794
angiotensin II
7818
Ang II
4221
Sep
2269
angiotensinogen
2028
vasopressin
1605
insulin
1601
Renin
1565
ACE
1326
angiotensin receptor
1157
AT1
1156
atrial natriuretic peptide
1118
Mol
1006
ANG
988
angiotensin II receptor
845
bradykinin
736
ACTH
735
kallikrein
633
albumin
621
atrial natriuretic factor
615
calcium channel
575
arginine vasopressin
562
Angiotensin-converting enzyme
551
collagen
540
PRA
533
mineralocorticoid receptor
486
ACE2
426
AT2
413
AT1R
388
natriuretic peptide
387
angiotensin-converting enzyme 2
382
nitric oxide synthase
321
renin receptor
321
endothelin-1
298
neutral endopeptidase
295
beta-endorphin
278
ATPase
277
chronic renal failure
274
prolactin
271
urinary kallikrein
270
cytokine
257
GFR
244
proximal tubule
237
ANP
218
Angiotensinogen
211
SARS
208
parathyroid hormone
198
aldosterone synthase
191
cyclooxygenase
182
hemoglobin
180
growth hormone
176
erythropoietin
174
cathepsin D
173
angiotensin I-converting enzyme
169
vascular endothelial growth factor
162
tumor necrosis factor
158
adrenocorticotropic hormone
152
angiotensin I converting enzyme
147
ARB
147
TNF
143
collecting duct
143
beta 1
143
CYP11B2
142
leptin
139
TGR
137
AVP
136
Pol
136
Mal
134
glucagon
133
AMP
132
plasminogen activator inhibitor-1
130
sodium channel
127
AII
124
polypeptide
122
She
121
gut
120
IL-6
117
cyclooxygenase-2
116
chymase
116
fibronectin
116
more...
Disease
hypertension
12154
essential hypertension
2687
heart failure
2521
diabetes
2333
renal disease
1773
cardiovascular disease
1199
ATM
1157
aldosteronism
1141
proteinuria
1123
congestive heart failure
1117
stroke
992
obesity
870
diabetic nephropathy
797
myocardial infarction
787
renal failure
785
atherosclerosis
716
ventricular hypertrophy
665
type 2 diabetes
635
renal artery stenosis
580
tumor
504
chronic renal failure
430
Conn
417
adenoma
409
cirrhosis
387
glomerulosclerosis
385
SEM
350
ischemia
346
metabolic syndrome
346
hyperglycemia
345
cancer
340
microalbuminuria
305
coronary artery disease
300
dehydration
269
myocardial ischemia
268
SARS
267
secondary hypertension
258
renal insufficiency
244
dyslipidemia
235
Goldblatt
233
preeclampsia
228
Bartter's syndrome
227
renal hypertension
225
depression
219
NAME
215
acute renal failure
207
cold
191
vascular disease
187
acute myocardial infarction
184
malignant hypertension
180
nephrotic syndrome
174
renal impairment
170
wasting
165
metabolic alkalosis
161
coronary heart disease
156
adrenal hyperplasia
146
anemia
145
heart disease
144
type 1 diabetes
144
hyperinsulinemia
137
glomerulonephritis
136
Cushing's syndrome
135
Alzheimer's disease
131
cardiomyopathy
125
retinopathy
124
plaque
123
pheochromocytoma
123
hypoaldosteronism
120
renal ischemia
118
diabetic retinopathy
114
adrenal adenoma
113
fluid overload
109
glucose intolerance
107
ADH
105
nephrosclerosis
104
vitamin D deficiency
103
dysplasia
102
polycystic kidney
100
hyperlipidemia
100
hypernatremia
94
hypercholesterolemia
91
more...
Symptom
anesthesia
316
polyuria
138
cough
113
headache
109
weakness
99
overweight
98
angina
87
fatigue
82
pain
82
vomiting
74
respiratory distress
72
dyspnea
62
diarrhea
60
exhaustion
53
dizziness
50
polydipsia
49
oliguria
48
hypercapnia
39
collapse
37
nausea
34
tense
33
seizures
33
syncope
32
cachexia
29
anorexia
25
flushing
22
analgesia
22
masculinization
22
starvation
21
constipation
21
hypothermia
19
thinning
17
hypoproteinemia
16
abdominal pain
16
Macula
15
chest pain
14
lethargy
14
functional recovery
13
acute stress
13
discomfort
12
Ill
12
discomfort
12
shortness of breath
12
regurgitation
11
hyperoxia
11
sleepiness
11
sinus pressure
11
myalgia
11
rales
10
presyncope
10
menopausal symptoms
10
Cushingoid
9
flank pain
9
adipsia
9
agitation
9
Cushingoid
9
tremor
8
hunger
8
spasm
8
Decreased activity
7
enuresis
7
hypotonia
7
numbness
7
back pain
7
lassitude
6
loss of taste
6
Stiffness
6
tingling
5
excessive sweating
5
cardiovascular impairment
5
hypertonia
5
arthralgia
4
asthenia
4
disturbed balance
4
insomnia
4
hot flushes
4
chills
4
hangover
4
hot flashes
4
decreased appetite
4
more...
Drug
Cardiovasc
1291
Angiotensin II
1161
Captopril
647
Nephron
362
Nephron
242
Aliskiren
226
Indomethacin
176
Dial
176
MAP
124
Ramipril
95
lysine
79
nitroglycerin
74
Valsartan
69
Clonidine
61
caffeine
55
Perindopril
53
ETA
51
ROS
48
Atenolol
45
Gel
38
PTH
37
Monit
36
Ouabain
36
Olmesartan
34
Cilazapril
32
ICI
31
Hydrochlorothiazide
31
Asn
29
CSF
29
Enalaprilat
28
Enalaprilat
28
Aprotinin
27
Amiloride
27
Amiloride
24
EE2
22
Omapatrilat
22
Forskolin
21
CaCl2
21
CaCl2
20
CaCl2
20
Portal
19
Dermatol
19
vitamin E
19
Triclosan
18
Diurnal
18
Albumin
17
Phentolamine
17
Ethanol
17
Pepstatin
17
Theophylline
17
Fenoldopam
15
Fraction
15
ascorbate
14
Glucagon
14
Growth hormone
14
NAG
14
Growth hormone
14
Felodipine
13
Ibopamine
13
CTX
12
Nebivolol
12
Isradipine
12
THF
12
Digitalis
12
Ringer's solution
12
NADH
11
Xanthium
10
Drospirenone
10
Bosentan
10
AHF
10
Fructose
10
Papaverine
10
Cilnidipine
10
Bosentan
10
Trandolapril
10
Inderal
9
Indapamide
9
Estrogens
9
MRC
9
Tolvaptan
9
more...
Enzyme
renin
35795
ACE
3111
kallikrein
725
PRA
540
CD10
331
trypsin
297
ATPase
296
mitogen-activated protein kinase
289
NADPH oxidase
249
angiotensin-converting enzyme 2
235
NADPH oxidase
202
protein kinase C
172
cathepsin D
169
NO synthase
166
pepsin
164
protein kinase
129
ERK
117
chymase
114
superoxide dismutase
111
alcohol dehydrogenase
105
ADH
105
MAP
104
AGT
96
phosphodiesterase
94
adenylate cyclase
81
guanylate cyclase
81
aminopeptidase A
74
catalase
72
tissue kallikrein
70
reverse transcriptase
65
peroxidase
64
prostaglandin synthetase
59
11beta-hydroxysteroid dehydrogenase
56
calcineurin
56
tissue plasminogen activator
56
creatine kinase
53
focal adhesion kinase
52
RNase
50
RNase
50
collagenase
50
plasmin
49
chymotrypsin
45
alkaline phosphatase
44
NOS
43
PAH
43
tyrosine hydroxylase
43
caspase-3
42
luciferase
41
phospholipase C
39
CD13
38
thrombin
38
phospholipase A2
35
AMP-activated protein kinase
35
HSD
33
lipoxygenase
30
xanthine oxidase
29
cathepsin B
28
21-hydroxylase
27
furin
26
cathepsin G
26
phosphatidylinositol 3-kinase
26
MEK
26
proteasome
26
RNA polymerase
25
HIV-1 protease
25
lactate dehydrogenase
24
AMPK
23
aspartate aminotransferase
21
urokinase-type plasminogen activator
20
glutathione peroxidase
20
transcriptase
20
alanine aminotransferase
20
endothiapepsin
20
beta-galactosidase
19
dopamine beta-hydroxylase
19
ribonuclease
18
ribonuclease
18
elastase
18
chloramphenicol acetyltransferase
18
chymosin
17
more...
Compound
aldosterone
11503
sodium
7372
Clin
4807
water
2950
Dec
2752
salt
2715
potassium
2643
Angiotensin II
2023
Ang II
1828
calcium
1808
acetate
1655
creatinine
1495
glucose
1211
Cardiol
1059
nitric oxide
1017
noradrenaline
949
oxygen
904
ACTH
745
arginine
530
DNA
503
urea
366
Sodium
339
cAMP
327
prostacyclin
327
Losartan
321
PGE2
310
cGMP
279
vitamin D
275
phosphate
242
sodium chloride
240
Salt
221
Adrenal
214
Enalapril
208
His
207
tyrosine
203
Phe
200
nitrogen
200
leucine
185
Insulin
183
Indomethacin
174
Dial
174
Propranolol
163
Ile
160
Propranolol
159
DOCA
159
alanine
153
sulfate
150
TNF
143
hydrogen
141
lysine
140
AMP
140
TGR
137
Isoproterenol
132
Salix
129
serine
122
Norepinephrine
120
ATP
115
CO2
114
Asp
113
ethanol
111
MAP
105
alcohol dehydrogenase
105
nitrate
102
galactose
102
PGE
101
Angiotensin I
96
zinc
95
EDTA
94
Pac
94
EDTA
94
Telmisartan
91
Spironolactone
90
GMP
90
Vitamin D
89
Nifedipine
88
5-HT
86
DBP
85
Dopamine
84
DBP
84
proline
84
more...