Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.15 (renin)
35,795 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
renin 35794
angiotensin II 7818
Ang II 4221
Sep 2269
angiotensinogen 2028
vasopressin 1605
insulin 1601
Renin 1565
ACE 1326
angiotensin receptor 1157
AT1 1156
atrial natriuretic peptide 1118
Mol 1006
ANG 988
angiotensin II receptor 845
bradykinin 736
ACTH 735
kallikrein 633
albumin 621
atrial natriuretic factor 615
calcium channel 575
arginine vasopressin 562
Angiotensin-converting enzyme 551
collagen 540
PRA 533
mineralocorticoid receptor 486
ACE2 426
AT2 413
AT1R 388
natriuretic peptide 387
angiotensin-converting enzyme 2 382
nitric oxide synthase 321
renin receptor 321
endothelin-1 298
neutral endopeptidase 295
beta-endorphin 278
ATPase 277
chronic renal failure 274
prolactin 271
urinary kallikrein 270
cytokine 257
GFR 244
proximal tubule 237
ANP 218
Angiotensinogen 211
SARS 208
parathyroid hormone 198
aldosterone synthase 191
cyclooxygenase 182
hemoglobin 180
growth hormone 176
erythropoietin 174
cathepsin D 173
angiotensin I-converting enzyme 169
vascular endothelial growth factor 162
tumor necrosis factor 158
adrenocorticotropic hormone 152
angiotensin I converting enzyme 147
ARB 147
TNF 143
collecting duct 143
beta 1 143
CYP11B2 142
leptin 139
TGR 137
AVP 136
Pol 136
Mal 134
glucagon 133
AMP 132
plasminogen activator inhibitor-1 130
sodium channel 127
AII 124
polypeptide 122
She 121
gut 120
IL-6 117
cyclooxygenase-2 116
chymase 116
fibronectin 116
more...
Disease
hypertension 12154
essential hypertension 2687
heart failure 2521
diabetes 2333
renal disease 1773
cardiovascular disease 1199
ATM 1157
aldosteronism 1141
proteinuria 1123
congestive heart failure 1117
stroke 992
obesity 870
diabetic nephropathy 797
myocardial infarction 787
renal failure 785
atherosclerosis 716
ventricular hypertrophy 665
type 2 diabetes 635
renal artery stenosis 580
tumor 504
chronic renal failure 430
Conn 417
adenoma 409
cirrhosis 387
glomerulosclerosis 385
SEM 350
ischemia 346
metabolic syndrome 346
hyperglycemia 345
cancer 340
microalbuminuria 305
coronary artery disease 300
dehydration 269
myocardial ischemia 268
SARS 267
secondary hypertension 258
renal insufficiency 244
dyslipidemia 235
Goldblatt 233
preeclampsia 228
Bartter's syndrome 227
renal hypertension 225
depression 219
NAME 215
acute renal failure 207
cold 191
vascular disease 187
acute myocardial infarction 184
malignant hypertension 180
nephrotic syndrome 174
renal impairment 170
wasting 165
metabolic alkalosis 161
coronary heart disease 156
adrenal hyperplasia 146
anemia 145
heart disease 144
type 1 diabetes 144
hyperinsulinemia 137
glomerulonephritis 136
Cushing's syndrome 135
Alzheimer's disease 131
cardiomyopathy 125
retinopathy 124
plaque 123
pheochromocytoma 123
hypoaldosteronism 120
renal ischemia 118
diabetic retinopathy 114
adrenal adenoma 113
fluid overload 109
glucose intolerance 107
ADH 105
nephrosclerosis 104
vitamin D deficiency 103
dysplasia 102
polycystic kidney 100
hyperlipidemia 100
hypernatremia 94
hypercholesterolemia 91
more...
Symptom
anesthesia 316
polyuria 138
cough 113
headache 109
weakness 99
overweight 98
angina 87
fatigue 82
pain 82
vomiting 74
respiratory distress 72
dyspnea 62
diarrhea 60
exhaustion 53
dizziness 50
polydipsia 49
oliguria 48
hypercapnia 39
collapse 37
nausea 34
tense 33
seizures 33
syncope 32
cachexia 29
anorexia 25
flushing 22
analgesia 22
masculinization 22
starvation 21
constipation 21
hypothermia 19
thinning 17
hypoproteinemia 16
abdominal pain 16
Macula 15
chest pain 14
lethargy 14
functional recovery 13
acute stress 13
discomfort 12
Ill 12
discomfort 12
shortness of breath 12
regurgitation 11
hyperoxia 11
sleepiness 11
sinus pressure 11
myalgia 11
rales 10
presyncope 10
menopausal symptoms 10
Cushingoid 9
flank pain 9
adipsia 9
agitation 9
Cushingoid 9
tremor 8
hunger 8
spasm 8
Decreased activity 7
enuresis 7
hypotonia 7
numbness 7
back pain 7
lassitude 6
loss of taste 6
Stiffness 6
tingling 5
excessive sweating 5
cardiovascular impairment 5
hypertonia 5
arthralgia 4
asthenia 4
disturbed balance 4
insomnia 4
hot flushes 4
chills 4
hangover 4
hot flashes 4
decreased appetite 4
more...
Drug
Cardiovasc 1291
Angiotensin II 1161
Captopril 647
Nephron 362
Nephron 242
Aliskiren 226
Indomethacin 176
Dial 176
MAP 124
Ramipril 95
lysine 79
nitroglycerin 74
Valsartan 69
Clonidine 61
caffeine 55
Perindopril 53
ETA 51
ROS 48
Atenolol 45
Gel 38
PTH 37
Monit 36
Ouabain 36
Olmesartan 34
Cilazapril 32
ICI 31
Hydrochlorothiazide 31
Asn 29
CSF 29
Enalaprilat 28
Enalaprilat 28
Aprotinin 27
Amiloride 27
Amiloride 24
EE2 22
Omapatrilat 22
Forskolin 21
CaCl2 21
CaCl2 20
CaCl2 20
Portal 19
Dermatol 19
vitamin E 19
Triclosan 18
Diurnal 18
Albumin 17
Phentolamine 17
Ethanol 17
Pepstatin 17
Theophylline 17
Fenoldopam 15
Fraction 15
ascorbate 14
Glucagon 14
Growth hormone 14
NAG 14
Growth hormone 14
Felodipine 13
Ibopamine 13
CTX 12
Nebivolol 12
Isradipine 12
THF 12
Digitalis 12
Ringer's solution 12
NADH 11
Xanthium 10
Drospirenone 10
Bosentan 10
AHF 10
Fructose 10
Papaverine 10
Cilnidipine 10
Bosentan 10
Trandolapril 10
Inderal 9
Indapamide 9
Estrogens 9
MRC 9
Tolvaptan 9
more...
Enzyme
renin 35795
ACE 3111
kallikrein 725
PRA 540
CD10 331
trypsin 297
ATPase 296
mitogen-activated protein kinase 289
NADPH oxidase 249
angiotensin-converting enzyme 2 235
NADPH oxidase 202
protein kinase C 172
cathepsin D 169
NO synthase 166
pepsin 164
protein kinase 129
ERK 117
chymase 114
superoxide dismutase 111
alcohol dehydrogenase 105
ADH 105
MAP 104
AGT 96
phosphodiesterase 94
adenylate cyclase 81
guanylate cyclase 81
aminopeptidase A 74
catalase 72
tissue kallikrein 70
reverse transcriptase 65
peroxidase 64
prostaglandin synthetase 59
11beta-hydroxysteroid dehydrogenase 56
calcineurin 56
tissue plasminogen activator 56
creatine kinase 53
focal adhesion kinase 52
RNase 50
RNase 50
collagenase 50
plasmin 49
chymotrypsin 45
alkaline phosphatase 44
NOS 43
PAH 43
tyrosine hydroxylase 43
caspase-3 42
luciferase 41
phospholipase C 39
CD13 38
thrombin 38
phospholipase A2 35
AMP-activated protein kinase 35
HSD 33
lipoxygenase 30
xanthine oxidase 29
cathepsin B 28
21-hydroxylase 27
furin 26
cathepsin G 26
phosphatidylinositol 3-kinase 26
MEK 26
proteasome 26
RNA polymerase 25
HIV-1 protease 25
lactate dehydrogenase 24
AMPK 23
aspartate aminotransferase 21
urokinase-type plasminogen activator 20
glutathione peroxidase 20
transcriptase 20
alanine aminotransferase 20
endothiapepsin 20
beta-galactosidase 19
dopamine beta-hydroxylase 19
ribonuclease 18
ribonuclease 18
elastase 18
chloramphenicol acetyltransferase 18
chymosin 17
more...
Compound
aldosterone 11503
sodium 7372
Clin 4807
water 2950
Dec 2752
salt 2715
potassium 2643
Angiotensin II 2023
Ang II 1828
calcium 1808
acetate 1655
creatinine 1495
glucose 1211
Cardiol 1059
nitric oxide 1017
noradrenaline 949
oxygen 904
ACTH 745
arginine 530
DNA 503
urea 366
Sodium 339
cAMP 327
prostacyclin 327
Losartan 321
PGE2 310
cGMP 279
vitamin D 275
phosphate 242
sodium chloride 240
Salt 221
Adrenal 214
Enalapril 208
His 207
tyrosine 203
Phe 200
nitrogen 200
leucine 185
Insulin 183
Indomethacin 174
Dial 174
Propranolol 163
Ile 160
Propranolol 159
DOCA 159
alanine 153
sulfate 150
TNF 143
hydrogen 141
lysine 140
AMP 140
TGR 137
Isoproterenol 132
Salix 129
serine 122
Norepinephrine 120
ATP 115
CO2 114
Asp 113
ethanol 111
MAP 105
alcohol dehydrogenase 105
nitrate 102
galactose 102
PGE 101
Angiotensin I 96
zinc 95
EDTA 94
Pac 94
EDTA 94
Telmisartan 91
Spironolactone 90
GMP 90
Vitamin D 89
Nifedipine 88
5-HT 86
DBP 85
Dopamine 84
DBP 84
proline 84
more...