Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The renal effects of i.v. saline loading equal to 1% body weight (b.wt.) were studied in 2 groups of rats: group I was anesthetized with Amytal (15 mg/100 g b.wt. plus supplementary doses), group II with Inactin (12.5-15.0 mg/100 g b.wt.). In group I the saline load caused an increase in urine flow (+92%), solute excretion (+67%), inulin clearance (CIN) (+24%), PAH clearance (+31%) and absolute proximal reabsorption rate (+27%). Proximal fractional reabsorption and filtration fraction (FF) remained unchanged, while plasma oncotic pressure (COP) decreased by 10%. Plasma renin fell and there was an inverse relationship between renin concentration and proximal reabsorption rate. In group II urine flow and solute excretion increased after saline (+85% and 110%, respectively); CIN and absolute proximal reabsorption rate was lower than in group I and failed to increase after saline. Proximal fractional reabsorption was also lower and decreased after saline. COP as well as renin decreased as in group I, but no relationship between renin concentration and proximal reabsorption rate could be demonstrated. The data indicate that Inactin depresses both resting proximal tubular reabsorptive capacity and the tubular response to a physiological volume expansion. The results are compatible with the hypothesis that the renin-angiotensin system is significantly involved in regulation of proximal tubular function, while they are incompatible with the idea that peritubular COP plays any major role in this adjustment.
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PMID:The effect on total renal and tubular function and plasma renin of a moderate isotonic saline load in rats anesthetized with amytal and inactin. 118 88

The effects of indomethacin (I), a blocker of prostaglandin (PG)-synthetase, was studied in rats in an attempt to elucidate the physiological role of renal PGE. Plasma-I-concentrations of 13-14 mug/ml reduced renal venous plasma PGE-concentration significantly from 216 to 85 pg/ml within 45 min. Urine flow and solute excretion decreased by 42% and 20%, respectively, while urine osmolality increased 450 mOsm. Inulin clearance (CIN) and proximal reabsorption rate was unaffected, while renal plasma flow (RPF) decreased by 18%. Plasma renin concentration decreased slightly but significantly. An i.v. saline load equal to 1% b.wt. given to I-treated rats failed to elevate significantly either urine flow, solute excretion, CIN, RPF or proximal reabsorption rate, but plasma renin decreased further. The normal inverse relationship between plasma renin and proximal reabsorption rate was absent. The data are consistent with the concept that intrarenal PGE plays in adjustment of renal vascular resistance, and support the concept of a physiological role of intrarenal PGE in regulating salt and water excretion. The data do not support any major physiological role of PGE in regulating proximal tubular function.
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PMID:Indomethacin blockade of renal PGE-synthesis: effect on total renal and tubular function and plasma renin concentration in hydropenic rats and on their response to isotonic saline. 118 89

This study investigated the effects of exercise intensity on renal hemodynamics. Three healthy male subjects underwent exercise tests on a bicycle ergometer at 7 different work loads for 15 min. The indicators of exercise intensity employed in this study were the percentage of maximal oxygen uptake (%VO2max) and percentage of ventilatory threshold (%VT). As renal clearance parameters, para-aminohippurate clearance (CPAH) and inulin clearance (CIN) were measured by the continuous infusion technique. Indicators of renal hemodynamics during exercise were the percentage of CPAH, CIN and filtration fraction (FF) at rest. Plasma norepinephrine (NE), plasma epinephrine (E) and plasma renin activity (PRA) were measured. The best regression models between renal clearance parameters and exercise intensity were selected using Akaike's information criterion (AIC). 1) The renal clearance parameters used during exercise were %CPAH, which determined the cubic regression model and %CIN, which determined the quadratic regression model as the exercise intensity increased using AIC. 2) The percentage of maximal oxygen uptake at the onset of decrease in %CPAH and %CIN were 35 and 49%VO2max, respectively, while %CPAH and %CIN began to decrease at 75 and 105%VT, respectively. Intensity of exercise at the onset of increase in %FF was 49%VO2max or 106%VT. 3) The renal clearance parameters during exercise decreased linearly as NE, E and PRA increased. The increase in NE contributed mainly to a change in renal clearances shown by multiple regression analysis. The above results suggest that the relationship among renal plasma flow (RPF), glomerular filtration rate (GFR) and exercise intensity were demonstrated by the cubic regression model and quadratic regression model using AIC, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Exercise intensity and renal hemodynamics]. 747 5

We studied the renin-angiotensin system (RAS) and atrial natriuretic peptide (ANP) after amino acid loading in order to elucidate whether or not glomerular hyperfiltration is mediated by these hormones. Eight healthy controls without kidney disease (group 1), 8 renal graft recipients (group 2) and 8 patients after nephrectomy (group 3) were studied. Furthermore, we investigated the influence of amino acid loading on RAS and ANP and glomerular filtration during acute application of captopril in healthy controls. Clearances in insulin (CIn) and para-aminohippuric acid (CPAH) were determined during an infusion of 0.9% saline and during amino acid loading. CIn increased in healthy controls from 96.5 +/- 3.3 to 111.9 +/- 4.4 ml/min (p < 0.01), CPAH rose from 577 +/- 28.7 to 618.9 +/- 38 ml/min (p = NS). During the combined application of amino acid infusion and 25 mg captopril, CIN increased to 125.0 +/- 16.4 ml/min/1.73 m2 (p < 0.01) and there was no significant increase in CPAH which was 595 +/- 77 ml/min/1.73 m2. There was no significant change in renal vascular resistance, but filtration fraction increased from 17 +/- 1 to 19 +/- 1% under amino acid infusion and increased further under the application of captopril to 21 +/- 2% (p < 0.05). In renal graft recipients, CIn had a tendency to increase during amino acid infusion from 78.4 +/- 5.8 to 84.7 +/- 6.5 ml/min (p = NS). In patients after nephrectomy, CIn did not increase (84.5 +/- 6 ml/min) but CPAH did from 345.7 +/- 26.3 to 409 +/- 24.1 ml/min (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Influence of the renin-angiotensin system and atrial natriuretic peptide on renal functional reserve. 810 49