Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 7 splenectomized dogs a left renal vein-splenic vein anastomosis was performed and the right kidney removed. Eighteen to twenty-four months after portalization of renal venous blood no significant alterations of liver function tests were observed. Long-term diversion of renal venous blood into the liver was followed by a slight increase of creatinine and 25-OH-D, a decrease of alpha-amino acid nitrogen in blood plasma and of plasma renin activity in peripheral blood, by signs of slight carbohydrate intolerance despite hyperinsulinaemia, and a slight decrease of erythrocyte count. No influence of this procedure on plasma proteins, lipids, electrolytes, aldosterone and cortisol was found. No morphological abnormalities in the liver and kidney tissue were found.
Acta Physiol Pol
PMID:Metabolic effects of long-term diversion of renal venous blood into the portal system. 637 61

The influence of clonidine, guanethidine and furosemide on the development of arterial hypertension was studied in rats with hypertension induced by repeated administration of lysine vasopressin. It was found that these drugs administered during long time periods together with lysine vasopressin prevented the development of arterial hypertension. When any of these drugs was given in combination with vasopressin plasma renin activity failed to rise and the level and turnover of catecholamines in rat brain were unchanged.
Acta Physiol Pol
PMID:Effects of clonidine, guanethidine and furosemide on the development of vasopressin hypertension in rat. 700 88

Plasma renin activity, aldosterone and cortisol levels, as well as renal blood flow were studied in borderline and established hypertensive patients and in healthy control subjects at rest and following graded dynamic upright exercise. Resting plasma renin activity was elevated in established hypertension, renal blood flow at rest was decreased in patients with borderline hypertension but its per cent decrease during exercise was similar in all groups. Following exercise, plasma renin activity increased in all groups but a step-wise increase with graded exercise occurred only in borderline hypertension. Resting plasma aldosterone and cortisol levels were similar in all groups. In the hypertension patients physical exercise was associated with disproportional changes of plasma renin activity and aldosterone levels. Plasma cortisol displayed patterns which were roughly similar to those or aldosterone in the control group an in established hypertension, but not in the borderline group, where the most pronounced increased of aldosterone level was associated with the lowest level of cortisol. It is concluded that the physiological response of the renin-angiotensin-aldosterone system to physical exercise is altered in essential hypertension.
Acta Physiol Pol
PMID:Plasma renin activity, aldosterone and cortisol levels during physical exercise in essential hypertension. 701 72

A high rate of cardiovascular death in renal patients, particularly patients with endstage renal failure, has not been well appreciated in the past. It is obvious that cardiovascular lesions are more severe than can be explained by the classical risk factors of elevated blood pressure and dyslipidemia. In renal failure, a number of pathomechanisms are operative which may be paradigms of more general relevance, e.g. activation of the renin and sympathetic system, inhibition of the vasoconstrictor NO system, left ventricular hypertrophy in excess of what is expected for high blood pressure. A paradox inverse relation between lipid concentrations and cardiovascular death, i.e. a protective effect of hyperlipidemia, in dialysed patients, presumably results from the confounding effect of malnutrition, high lipid levels being a substitute marker of adequate nutrition.
Pol Arch Med Wewn 1994
PMID:Excess cardiovascular mortality in the uremic patient--what does it teach for other risk factors in the non-renal patient? 773 91

This study aimed to assess the effect of anaemia on volume related hormones in dialyzed patients with chronic uraemia. Three groups of subjects were examined. The first one comprised 34 hemodialyzed patients with severe anaemia (haematocrit value < 28%). 17 patients were treated with EPO for 1 year (EPO group) while the other 17 patients did not receive rHuEPO (no-EPO group) but were intensively monitored biochemically and clinically as patients of the EPO group. The second group (HD) consisted of 12 hemodialyzed uraemic patients with a Hct > 30% without rHuEPO treatment, while the third one comprised 15 healthy subjects. In patients of the EPO and no-EPO group plasma renin activity (PRA), plasma concentration of aldosterone (Ald) atrial natriuretic peptide (ANP and vasopressin (AVP) were assessed before (0) and after 3, 6, 9 and 12 months of clinical monitoring, while in patients of the HD group and in normals the above mentioned parameters were estimated only once. EPO treatment improved significantly the Hct value already after three months of therapy. No significant changes in PRA and plasma concentrations of Ald, ANP and AVP in the noEPO group were noticed during 12 months of monitoring. In contrast EPO treatment induced a significant, although transitory decrease of PRA, Ald and AVP, but an increase of plasma ANP. No influence of rHuEPO therapy on blood pressure was noticed.(ABSTRACT TRUNCATED AT 250 WORDS)
Pol Arch Med Wewn 1994 Aug
PMID:[Does long-term human recombinant erythropoietin (rHuEPO) influence secretion of hormones regulating volume and pressure of arterial blood?]. 780 May 84

The aim of the study was the comparison of the effect of seven day treatment with nifedipine (2 x 10 mg daily) and subsequently with verapamil (3 x 40 mg daily) on blood pressure, heart rate, plasma ANP, cGMP, renin activity (PRA), aldosterone (ALDO) concentrations in patients with primary hypertension. The material consisted of 12 untreated patients with primary arterial hypertension Io WHO. These results suggest that short-term treatment with nifedipine and subsequently with verapamil in patients with primary hypertension Io WHO not influence on plasma ANP, cGMP, PRA and ALDO in spite of blood pressure reduction and the changes in heart rate. It seems that ANP did not participate in hypotensive action of nifedipine and verapamil. No augmentation of urinary sodium excretion was found after short-term treatment with nifedipine or verapamil.
Pol Tyg Lek
PMID:[Comparison of the effect of short-term treatment with nifedipine and verapamil on blood pressure, plasma atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP) in patients with primary arterial hypertension I degree according to WHO]. 786 84

The authors aim was to evaluate if the changes in the components of the plasma kinin system on PRA, determined during 3-weeks period of treatment with captopril in daily doses of 150 mg, depend on the stage of arterial hypertension. Investigations were carried out in 40 patients with primary hypertension; 6 patients were in I, 20 in II and 14 in III WHO stage. The control group consisted of 18 healthy persons. All the parameters were examined 3 times: before therapy, after 24 h and after 3 weeks of therapy. It was proved that captopril as monotherapy, was effective in every stage of hypertension, however the normalisation of blood pressure was observed only in I and II WHO stage. The normalisation of the prekallikrein levels appeared after 3 weeks of treatment in all periods of hypertension, while the normalisation of the kininogen levels occurred only in patients of I and II WHO stage. Since changes of kininogen level in plasma occurred along with changes in blood pressure, therefore the estimation of kininogen seems to be better criterium of effectiveness of captorpil than the determination of prekallikrein. The changes of PRA were similar in all stages of hypertension, but they were significant only in the group of patients of II WHO stage and only after 24 h. Presented studies indicate that renin-angiotensin-aldosterone system as well as kinin system, participate in the mechanism of antihypertensive effect of captopril in every stage of hypertension.
Pol Tyg Lek
PMID:[Changes of components in the kinin system and plasma renin activity during different stages of hypertension in patients treated with captopril]. 786 89

Plasma renin activity was assayed with RIA technique in 13t female patients with hypothyroidism, aged between 23 and 64 years (mean 43.1 years). It was found that mean plasma renin activity in the group under study was statistically significantly lower than that in analogue control group. These results may indicate a relationship between thyroid function and renin-angiotensin-aldosterone system.
Pol Tyg Lek
PMID:[Plasma renin activity in women with hypothyroidism]. 809 Jun 49

Plasma renin activity, blood aldosterone levels and ANP secretion have been studied in 15 patients with the acute non-inflammatory renal insufficiency prior to and after ACE blockade with captopril. The above parameters were investigated at rest and in water immersion. Captopril significantly enhanced plasma renin activity in both examined groups, and decreased blood serum aldosterone levels but only in healthy subjects. Captopril had no effect on serum ANP levels. Results did not reveal close correlation between ANP release and renin-angiotensin-aldosterone system activity in both healthy subjects and patients with the acute non-inflammatory renal insufficiency.
Pol Tyg Lek
PMID:[Function of the renin-angiotensin-aldosterone system and atrial natriuretic peptide secretion in patients with acute non-inflammatory renal insufficiency]. 817 Aug 13

The present study aimed to answer the following questions: 1. do secretion of volume related hormones in patients with EH pre and post treatment with captopril differ from normotensive subjects if examined in thermal dehydration conditions; 2. is the electrolyte composition of thermal sweat related to the plasma profile of volume related hormones? and 3. does treatment by captopril influence sweat electrolytes in EH patients. In 16 patients with EH and in 20 healthy subjects a thermal dehydration test was performed. In patients with EH this test was done twice: before treatment and after 6 weeks of captopril therapy. In all subjects plasma renin activity (PRA), aldosterone (Ald) AVP and ANP were measured before and after thermal dehydration. In sweat samples collected after 15' and 45' of thermal dehydration the concentration of Na, K and Cl was assessed. In hypertensive patients before captopril treatment significantly higher values of PRA, ALD and ANP were found, while sweat concentrations of Na and Cl were significantly lower than in controls. After captopril treatment sweat electrolytes concentrations showed a tendency to normalize. No significant correlation was found between the plasma hormonal profile and sweat Na, K and Cl concentrations respectively both in controls and patients with EH pretreatment. A significant positive correlation was noticed only in hypertensive patients post-treatment between plasma aldosterone and sweat Na and Cl concentration respectively. Results obtained in this study show, that volume related hormones (Ald, AVP, ANP) do not seem to influence markedly the electrolyte composition of thermal sweat both in healthy subjects and in hypertensive patients.
Kardiol Pol 1993 Mar
PMID:[Hormones regulating volume and electrolytes of sweat in patients with essential hypertension. Effect of thermal dehydration and treatment with captopril]. 823 Sep 93


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