Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 19 patients with acute renal failure the plasma renin activity and aldosterone were determined in the phase of anuria and oliguria. A highly increased plasma renin activity was found while aldosteronemia was only moderately raised. No significant correlation was demonstrated between plasma renin activity and aldosterone while a negative correlation was found between aldosteronemia and plasma sodium and bicarbonates concentrations. Lack of significant correlation between plasma renin activity and aldosteronemia in cases of acute renal failure suggests that factors other than renin participate in the regulation of aldosterone secretion in these patients.
Pol Med Sci Hist Bull
PMID:Aldosteronemia in patients with acute renal failure. 18 68

Central action of catecholamines on the cardiovascular system in rats. Acta Physiol Pol., 1978, 29 (2): 123--130. It was demonstrated that noradrenaline, adrenaline, dopamine and isoproterenol as well as normethanephrine administered into the lateral ventricle of the rat brain, under urethane anaesthesia, caused significant changes in arterial blood pressure. This action is due to stimulation of central adrenergic receptors. Arterial blood pressure rise after intraventricular administration of noradrenaline is caused by activation of the renin-angiotensin system in the periphery. The results of these experiments point to a role of central catecholamines in functional regulation ofthe cardiovascular system.
Acta Physiol Pol
PMID:Central action of catecholamines on the cardiovascular system in rats. 20 81

Attention to the problem of hypertension in women using oral contraceptives has been increasing as the use of these preparations has increased. It is estimated that between 1-5% to 15-18% of those women using these preparations suffer from hypertension. Some sources have linked the occurrence of hypertension to a concentration of renin in the blood. It is not clear to this author, though, whether this is the result of some physiological disruption caused by the contraceptive, or caused by some other malfunction of this mechanism. The appearance of hypertension in the course of hormonal contraceptive use is considered to be an indication for the discontinuation of its use.
Pol Tyg Lek 1975 Feb 10
PMID:[Hypertension developing in women using oral contraceptions]. 23 12

A partially purified bovine renin preparation and a homologous renin substrate were used to study the effect of some lipids on the amount of angiotensin formed. It was found that lecithin and the detergents used (deoxycholate and sodium dodecylate) inhibited the renin activity. Palmitic acid, oleic acid and cholesterol had no distinct effect. On the other hand, the reaction was enhanced by prostaglandins E2 and F2alpha.
Acta Biochim Pol 1976
PMID:Effect of some lipids on the activity of renin in vitro. 101 52

Experiments were made on 15 mongrel dogs of either sex. Biologically active substances circulating in the blood after administration of noradrenaline (NA) into the left lateral brain ventricle of the dog were detected using the blood bathed organ technique of Vane. Plasma renin activity was also estimated. NA injected intraventricularly (ivc) in doses of 50-500 mug activated the renin--angiotensin system. Phentolamine prolonged the effect of NA. Propranolol abolished this central effect of NA. The increase in the concentration of endogenous NA in the brain by desmethylimipramine and RO 4-1284 also caused an activation of renin--angiotensin system.
Pol J Pharmacol Pharm
PMID:The activation of the renin--angiotensin system in the dog after injection of noradrenaline into the lateral brain ventricle. 120 33

In 22 patients with chronic cor pulmonale syndrome plasma renin activity (PRA) was determined at rest and after stimulation by means of intravenous injection of furosemide. In 50% of cases PRA was raised exceeding 250 ng/100 ml/3 hours. The systemic arterial pressure in these patients was normal. The degree of PRA increase after stimulation was lower than in healthy subjects.
Pol Med Sci Hist Bull
PMID:Plasma renin activity in patients with chronic cor pulmonale syndrome. 122 21

Function of the renin-angiotensin-aldosterone (RAA) system in kidney transplant patients (KTP) is often abnormal as in patients with chronic renal failure. On the other hand the importance of opioids in the regulation of function of endocrine organs is well established. These facts were the background of studies presented in this paper. They aimed to assess the role of opioid receptors in the regulation of the RAA in KTP. 12 patients with a stabilized renal graft function and on cyclosporin A + prednisone therapy and 15 healthy subjects were examined. In all subjects plasma renin activity (PRA), plasma aldosterone level (Ald) and blood pressure were assessed during a 4 hr bed-rest test. In each subject two tests were performed: the first one without naloxone administration, and the second one--after opioid receptor blockade. In KTP significantly elevated PRA and blood pressure and moderately elevated plasma Ald levels were found as compared with normals. After a 4 hr bed rest without naloxone no significant changes of the above mentioned parameters were noticed both in the patients and the controls. After opioid receptors blockade by naloxone a significant decrease of PRA and plasma Ald was observed in both examined groups. This decrease was significantly more marked in KTP than in controls. In addition only in KTP 4 hrs after naloxone administration a significant increase of systolic and diastolic blood pressure was found. Results obtained in this study suggest, that opioid receptors are involved in the regulation of the activity of the RAA system and of blood pressure more markedly in KTP than in healthy subjects.
Pol Arch Med Wewn 1992 Nov
PMID:[Effect of opioid receptor blockade with naloxone on plasma renin activity and aldosterone levels in patients with kidney transplantation]. 130 May 52

Renal erythropoietin production is dependent on local oxygen content of blood which activates so called "oxygen sensors". Taking into consideration altered local renal blood supply in patients with arterial hypertension in the course of arteritis (HA) and from the other side contribution of the renin-angiotensin system in both pathogenesis of hypertension and regulation of erythropoietin production it seemed plausible to undertake this study. The aim of the study was to determine whether and in what extent patients with HA and healthy subjects differ in EPO secretion and whether EPO serum level is related in this patients to renin response to dietary sodium restriction and upright position of the body. 18 patients with HA and 12 healthy subjects were investigated. In all subjects haematocrit value, haemoglobin concentration, erythrocyte count, sodium, potassium, creatinine, iron, ferritin serum levels, total iron binding capacity, plasma renin activity (PRA), erythropoietin serum level and mean arterial blood pressure (MAP) were measured in basic conditions (normal sodium diet). Additionally PRA, EPO and MAP were measured after dietary sodium restriction to 10-20 mmol Na/24 hrs for three days and upright position of the body for three hours. Patients with HA had insignificantly lower serum EPO concentrations than healthy subjects and both studied groups did not differ in haematocrit value and determinants of iron metabolism except of significantly higher ferritin concentration in HA. After dietary sodium restriction and upright position of the body significant rise in PRA and no significant changes in EPO level were found in studied groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Pol Arch Med Wewn 1992 Dec
PMID:[The role of erythropoietin in blood pressure regulation in patients with arteritis]. 130 May 62

The group of the investigated included 25 individuals (11 F, 14 M), aged 55 +/- 1.5 years, with diabetes type II and hypertension. Known diabetes duration was 4.9 +/- 0.8 years and known hypertension duration--7.4 +/- 1.4 years. Two weeks after administering placebo in place of hypertension drugs applied so far, guanfacine was included as the only hypertensive drug. The dosage was increased from 0.5 mg up to 3 mg daily until a good control of blood pressure was achieved. The diabetic treatment, diet and the smoking habit were unchanged. The resting activity of the renin-angiotension-aldosterone system (RAA), cholesterol, triglycerides, HDL and LDL, serum glucose levels and HbA1c were assayed after a 5-month guanfacine period. After treatment a significant decrease in blood pressure both systolic and diastolic (p < 0.001), heart rate (p < 0.005) and plasma renin activity (p < 0.02) were observed. Preliminary measurements of RAA activity and its changes during treatment were not helpful in predicting guanfacine hypotensive effect. The level of lipids, lipoproteins, atherogenic factors, glucose and HbA1c did not change significantly during the study.
Pol Tyg Lek
PMID:[Effect of 5-month guanfacine treatment on the renin-angiotensin-aldosterone system and some metabolic factors in patients with diabetes mellitus type II and hypertension]. 130 23

Angiotensin-converting enzyme in the blood serum was assayed with Friedland's and Silverstein's Technique in 24 female patients with untreated hyperthyroidism accompanying Graves-Basedow disease. Mean ACE activity was significantly higher in patients than that in the group of healthy individuals of the same age. Increased ACE activity noted in patients with Graves-Basedow disease may, therefore, indicated a significant role of renin-angiotensin-aldosterone system in the etiopathogenesis of hypertension in this disease.
Pol Tyg Lek
PMID:[Activity of angiotensin-converting enzyme in women with hyperthyroidism accompanying Graves-Basedow disease]. 133 53


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