Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the renin-angiotensin system in the genetically hypertensive (HBP), normotensive (NBP) and low blood pressure (LBP) mice developed by G. Schlager, one of the authors. Renin in the plasma, kidney and submaxillary gland was determined by enzymatic assay and by direct radioimmunoassay (DRIA). Trypsinization of mouse plasma was also investigated. PRA and plasma renin content were not significantly different in the different lines, sexes and generations. Trypsinization of the plasma revealed the presence of inactive renin, as has also been found in humans, hogs, dogs and rats. The proportion of active renin against trypsinized total renin was about 54-77% and was not significant in the different lines, sexes and generations. There was also no significant difference in renal renin content in the various lines, sexes and generations. However, in the submaxillary gland, renin content and activity were high in male mice, in every line. These data suggest that the renin-angiotensin system may not contribute to the established phase of blood pressure.
 ...
PMID:Renin-angiotensin system in genetically hypertensive mice. 638 22

The objective of the study was to assess the evolution of renin, angiotensin II, atrial natriuretic factor (ANF) and blood pressure (BP) in the first trimester following renal transplantation in man Thirty-two recipients were investigated for 3 months post-transplantation. Twenty had a history of hypertension with moderate cardiac hypertrophy. Thirty-one retained their native kidneys. Five kidney donors had a history of mild hypertension. The recipients were perioperatively volume-expanded with 0.9% saline and diuresis was maintained for 48 h with furosemide and dopamine. The sodium intake was 25 mEq/24 hours. Prophylactic immunosuppressive therapy was antilymphocyteglobulins (25 cases), or anti-LFA1 (7 cases) and maintenance therapy was cyclosporine-prednisone (8 cases), or cyclosporine-prednisone-azathioprine (24 cases). Mean BP, serum creatinine, urinary sodium excretion (UNA) and hormonal (renin, angiotensin II and ANF) parameters were collected every other day for the first week after transplantation and then twice monthly. Twenty (62.5%) patients developed hypertension and hypertension was more frequent in patients with a delayed graft function, than in patients with immediate good graft function (10/20 vs. 4/12, p < 0.05%). Both hypertensive (group HBP) and normotensive (group NBP) patients had similar very low renin and angiotensin II plasma levels, after an initial early peak. Analysis of covariance with multiple regression analysis showed that in the HBP patients, BP was negatively correlated with UNA (p = 0.02) and positively with plasma ANF (p < 0.01). The normal BP patients also showed a correlation between BP and UNA, although it was limit of statistical significance (p = 0.05); there was no correlation between ANF and BP. We conclude that the RAS is rapidly depressed after renal transplantation and does not interfere with BP regulation. The hypertension in the early stage of post-transplantation varies inversely with the urinary sodium excretion. The defective sodium excretion, which dominates the effect of the low sodium diet, results in volume overload, increased ANF and volume-dependent hypertension.
 ...
PMID:Relationship between blood pressure and renin, angiotensin II and atrial natriuretic factor after renal transplantation. 928 46