Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.15 (
renin
)
35,795
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-
2-piperazinone
scaffold display equipotent
renin
inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.
...
PMID:Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors. 1583 27
