Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been established that the catecholamine-induced increase in renin secretion by juxtaglomerular apparatus cells and sodium reabsorption stimulation in the rat kidney are consequent on the excitation of renal beta-adrenoreceptors. Strophanthin K interferes with the renin-secreting action of adrenaline and perverts its activating effect on sodium transport by renal tubules. When given in a dose inhibiting angiotensin II formation and renin-secreting effect of catecholamines, heparin also diminishes their activating effect on tubular sodium transport. It is suggested that the renin-angiotensin system may be directly involved into the mechanism of catecholamine-stimulated sodium reabsorption by the rat kidney.
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PMID:[Interaction of catecholamines and the renin-angiotensin system in regulating sodium reabsorption in the rat kidney]. 700 10

Strophanthin (0.1 mg.kg, i.v.) and digoxin (0.1 mg/kg, i.v.) moderately increase blood supply of the renal cortical and medullary layers in unconscious rats and enhance renal excretion of sodium and water. Preadministration of the converting enzyme inhibitor captopril (10 mg/kg/day, per os, for 6 days) promoted vascular dilatation in the inner and outer areas of the medulla, which occurred under the action of these agents and substantially increased their natriuretic and diuretic effects. It is concluded that the renin-angiotension system is directly involved into the mechanism of action of cardiac glycosides in the kidneys, acting as a modulator that prevents their vasodilating and tubular effects.
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PMID:[The interaction of the converting-enzyme inhibitor captopril with cardiac glycosides in the rat kidney]. 778 94