Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.23.15 (
renin
)
35,795
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Calu-6 cells were characterized for studying the transcriptional regulation of the human
renin
gene. Analysis of cis-acting elements of the
renin
promoter showed the highest activity within the first 582 bp in serum-free conditions and of the 892 bp in the presence of serum. cAMP activates
renin
mRNA synthesis parallel to
renin
production (20-fold increase) as well
renin
promoter activity (2-fold). cAMP response element and the (-77 to -67) element are both necessary for activation of the
renin
promoter but do not act independently. Functional analysis of
Intron A
revealed the presence of a silencer specific to
renin
-producing cells.
...
PMID:Regulation of human renin secretion and gene transcription in Calu-6 cells. 916 95
