Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy of peripheral vasodilators with different action mechanisms was studied and compared in 96 patients with chronic circulatory failure, stages IIB-III, of different genesis (rheumatic fever, congestive cardiomyopathy, postinfarction cardiosclerosis). Isosorbide dinitrate was used in 16 patients, nitroglycerin in 36, pratsiol in 24, and captopryl in 20 patients. Monitoring of the ECG, heart rate, respiratory rate and arterial blood pressure as well as catheterization of the right heart and tetrapolar impedance plethysmography were performed. The parameters of the heart pre- and afterload, pulmonary hemodynamics as well as those characterizing myocardial contractility were measured. It was established that the successful use of the different vasodilators rests on an adequate determinations of the indications for use. Captopryl is particularly effective in grave circulatory failure associated with a dramatic activation of the renin-angiotensin system. Pratsiol is effective in all the cases of chronic CF, since the tone of the sympathoadrenal system is virtually always high in patients with grave decompensation. Pratsiol was particularly efficacious in chronic CF with mitral or aortal regurgitation.
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PMID:[Comparative evaluation of the effectiveness of various peripheral vasodilators in the treatment of cardiac insufficiency]. 392 1

An investigation into the renin-angiotensin-aldosterone system (RAAS) in patients of advanced age with ischaemic heart disease (IHD) and different degrees of atherosclerotic cardiosclerosis by means of radioimmunoassay, which was used to determine the renin activity and the aldosterone concentration in the plasma, showed that there is in IHD an activation of the above regulatory system even under the conditions of relative rest. Furthermore, it was found out that the renin activity of the plasma was increased only in male patients with IHD, whereas the aldosterone concentration was increased both in males and females. These findings justify the hypothesis on the pathogenetic role played by changes in the RAAS in IHD in old age. The more severe disorders of the RAAS as seen in male patients with IHD explain to some extent the earlier onset and greater severity of IHD in men. For the treatment of hyperaldosteronism, which has been found to be associated with IHD in persons of advanced age, it is necessary to include into the therapeutic plan of patients with IHD, in particular males, competitive aldosterone antagonists as well as beta-adrenergic blocking agents.
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PMID:[Peculiarities of the renin-angiotensin-aldosterone-system in elderly patients with ischaemic heart diseases (author's transl)]. 733 79

Rats with experimental cardiosclerosis detected 21 days after embolization of the coronary arteries were subjected to early chronic perindopril administration (per os, 2 mg/kg once a day on days 2-20 after immobilization. As a result, the number of scars reduced, focal cardiosclerosis, dystrophy and hypertrophy of the cardiomyocytes were less pronounced, and the content of cellular glycogen increased. The cardioprotective effect was attended with a normalizing influence on the renin-angiotensin system parameters which were significantly changed after experimental damage to the myocardium: perindopril restored angiotensin I clearance and the level of angiotensin II production in the lungs.
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PMID:[The cardioprotective effect of perindopril in rats with experimental cardiosclerosis]. 1034 Jan 21