Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.23.15 (renin)
 35,795 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A child with unilateral renal hypoplasia, high plasma renin levels and hypertension was found to have large numbers of juxtaglomerular granular cells in the affected kidney. They were seen adjacent to and sometimes in the interior of hyalinized glomeruli or, in loose nests scattered in the interstitium. Ultrastructurally they contained large numbers of crystalline protogranules in the Golgi region and also displayed other features suggestive of hyperactivity. Atrophic tubules, smooth muscle and mast cells were present in considerable numbers. Well-preserved renal cortex remained in the affected kidney with no demonstrable juxtaglomerular granularity. After unilateral nephrectomy the patient became normotensive and plasma renin levels became normal. Thus it appears that the juxtaglomerular cells are able to produce and release renin independent of the structural integrity of the juxtaglomerular apparatus and renal glomerulus.
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PMID:Unilateral renal hypoplasia with associated venous anomaly and hypertension. A study of the juxtaglomerular cells. 14 87

The most pronounced hyperplasia of the juxtaglomerular apparatus (JGA) with the appearance of numerous rhombus-like protogranules in the epithelioid cell cytoplasm is found electronmicroscopically in the mesangioproliferative glomerulonephritis (GM) with hypertension while in the membranous FN the hyperplasia was the least pronounced. Hyperplasia of JGA in the fibroplastic GN was observed in the preserved glomeruli only. Morphometric evaluation in mesangioproliferative GN has shown that there is an inverse relationship between the volume of the interstitium and the renin activity in the blood plasma, the positive correlation between the volume of the interstitium and blood pressure and the negative correlation between the elliptical shape of the granules in the JGA epithelioid cells and the surface of the interstitium. Atrophic changes in the interstitial cells are found.
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PMID:[Juxtaglomerular apparatus and interstitial cells of the kidney medulla in glomerulonephritis]. 671 13

The authors analyze the data of histochemical examinations of 30 patients with tumorous and nontumorous forms of low-renin hyperaldosteronism, as well as the findings of clinical and hormonal examinations of these patients. The activities of enzymes involved in steroidogenesis (3-beta OSD, NAD and NADP tetrazolium reductases, G-6-PD) were measured, as were levels and distribution patterns of lipids involved in steroidogenesis (free and bound cholesterol, etc.). A high functional activity of aldosteromas of any structure was proved, and a trend to increase of steroidogenic activity of malignant aldosteromas demonstrated. Atrophic changes in the cortex adjacent to aldosteroma were found to involve no reduction of adrenal tissue functional activity. In contrast to this, hyperplastic changes in the cortex adjacent to adenoma were characterized by a lower level of functional activity as against adrenal tissue activity in nontumorous hyperaldosteronism. The authors come to a conclusion that adrenocortical elements hyperplasia associated with some aldosteromas does not participate in aldosterone hyperproduction whereas hyperaldosteronism in nontumorous variants is caused by cortical cell hyperplasia and hormone hyperproduction.
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PMID:[Histochemical characteristics of aldosteromas and adrenal tissue of patients with primary hyperaldosteronism]. 816 9