Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.B10 (caspase-7)
 896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-3 538
caspase-9 229
PARP 159
Bcl-2 148
caspase-8 143
cytochrome c 109
p53 94
Mol 88
poly(ADP-ribose) polymerase 63
Sep 59
endoplasmic reticulum 57
p21 48
Fas 44
Bid 40
annexin V 37
caspase 7 36
p38 34
inhibitor of apoptosis 32
XIAP 30
JNK 27
ERK 26
calpain 25
poly (ADP-ribose) polymerase 25
bax 24
TNF 23
cyclin D1 21
survivin 21
Bak 21
GRP78 20
cytokine 20
MAPK 20
CHOP 20
p27 20
AKT 20
bcl-2 19
ERK1 18
Smac 18
Apaf-1 17
LC3 16
Mcl-1 16
mTOR 16
ADP 16
ATP 16
glucose-regulated protein 15
ROS 14
proteasome 14
PARP-1 14
Tumor necrosis factor 13
FasL 13
c-Jun 12
Fas ligand 12
CDK2 12
PERK 12
p65 11
apoptosis-inducing factor 11
estrogen receptor 11
X-linked inhibitor of apoptosis protein 11
tumor necrosis factor 11
granzyme B 11
cytochrome 10
cIAP2 10
IAP2 10
NMR 10
anti-apoptotic protein 10
DIABLO 10
pro-apoptotic protein 10
MEK 10
histone deacetylase 10
CDK6 10
tyrosine kinase 10
CDK4 9
cyclin A 9
proliferating cell nuclear antigen 9
PC-3 9
PI3K 9
FADD 9
catalase 9
ubiquitin 8
cyclin E 8
p38 mitogen-activated protein kinase 8
interferon 8
epidermal growth factor receptor 8
collagen 8
C/EBP homologous protein 8
CD95 8
Ki-67 8
cyclin 7
PC3 7
proteasome inhibitor 7
GSH 7
PKC 7
cyclin B1 7
lactate dehydrogenase 7
p23 7
histone 7
TNF-alpha 7
HSP70 7
superoxide dismutase 7
IL-6 7
dimeric 7
IL-8 7
lipopolysaccharide 6
Beclin-1 6
DR4 6
DR5 6
PTEN 6
TdT 6
SOD 6
MAP 6
NLRC4 6
H2AX 6
polypeptide 6
LDH 6
heat shock protein 6
IAP 6
cysteine protease 6
caspase 6 6
ACS 6
p62 6
BAX 6
Bax protein 6
p20 6
ICAD 6
MEK1 6
BiP 6
ATF6 6
IFN 5
glial fibrillary acidic protein 5
ATF4 5
TRAIL-R1 5
MTS 5
glutathione peroxidase 5
GSK 5
EGFR 5
AGS 5
LPS 5
ASC 5
CD40 5
Caspase-1 5
Chk1 5
Poly 5
cyclin-dependent kinase 5
extracellular signal-regulated kinase 5
AIF 5
PUMA 4
ATF 4
caspase 2 4
p38MAPK 4
IRE1 4
IL-18 4
mitogen-activated protein 4
ATPase 4
PARP1 4
BRAF 4
5-lipoxygenase 4
CD95L 4
JNK1 4
cathepsin G 4
PKR 4
TLR2 4
more...
Disease
cancer 256
tumor 149
MCF 119
breast cancer 105
carcinoma 33
tumor growth 30
colon cancer 27
leukemia 24
hepatocellular carcinoma 23
carcinogenesis 22
prostate cancer 20
B-cell lymphoma 19
lung cancer 18
colorectal cancer 17
glioma 17
adenocarcinoma 17
tumorigenesis 15
Alzheimer's disease 12
squamous cell carcinoma 12
ischemia 12
lymphoma 11
melanoma 10
neuroblastoma 10
tumor progression 9
acute myeloid leukemia 9
pancreatic cancer 9
gastric cancer 9
cervical cancer 8
renal cell carcinoma 8
liver cancer 8
non-small cell lung cancer 8
Blocking 8
GSH 7
retinoblastoma 7
esophageal cancer 7
esophageal cancer 7
Parkinson's disease 6
liver cancer 6
stroke 6
multiple myeloma 6
Kaposi's sarcoma 6
influenza 5
acute promyelocytic leukemia 5
DDP 5
Legionella 5
glioblastoma 5
infectious diseases 5
solid tumor 5
MTS 5
ovarian cancer 5
skin cancer 5
bladder cancer 5
AGS 5
glioblastoma multiforme 4
chronic myeloid leukemia 4
epithelial ovarian cancer 4
Hepatocellular carcinoma 4
diabetes 4
lung carcinoma 4
virus infection 4
fibrosarcoma 4
hepatitis C 4
myocardial ischemia 4
HIV 3
Huntington's disease 3
pneumonia 3
liver fibrosis 3
sepsis 3
cerebral ischemia 3
metastases 3
pheochromocytoma 3
hepatitis 3
sepsis 3
myocardial infarction 3
NOD 3
muscular atrophy 3
heart failure 3
osteosarcoma 3
endometrial cancer 3
amyotrophic lateral sclerosis 3
Infection 3
hypertension 2
medulloblastoma 2
cowpox 2
cardiovascular disease 2
ABL 2
aggressiveness 2
hyperosmolality 2
Pineal 2
Primary effusion lymphoma 2
Leukemia 2
herpes simplex 2
cirrhosis 2
mammary tumor 2
chronic lymphocytic leukemia 2
myeloid leukemia 2
fatty liver 2
hypoglycemia 2
metastatic breast cancer 2
acute lymphoblastic leukemia 2
cold 2
salmonellosis 2
chronic lymphocytic leukemia 2
atherosclerosis 2
brain cancer 2
epilepsy 2
ductal carcinoma 2
herpes 2
papillary thyroid cancer 2
ATM 2
retinitis pigmentosa 2
coronary artery disease 2
primary tumor 2
Melanoma 2
rheumatoid arthritis 2
arthritis 2
diabetic retinopathy 2
AIDS 2
acute myocardial infarction 2
DMS 2
Glioblastoma 2
cholera 2
HCC 2
APC 2
stomatitis 2
oral cancer 2
systemic lupus erythematosus 2
mesothelioma 2
thyroid cancer 2
acute renal failure 2
head and neck cancer 2
Hippel 2
brain tumor 2
Aleutian disease 1
uterus 1
malignant mesothelioma 1
infertility 1
Cryptococcus neoformans 1
dementia 1
male infertility 1
acute pancreatitis 1
inflammatory bowel disease 1
parkinsonism 1
DWI 1
gastrointestinal stromal tumor 1
plaque 1
uveitis 1
abortion 1
hematologic malignancies 1
vaccinia 1
MICA 1
Foot-and-mouth disease 1
sleep apnea 1
SDS 1
avian influenza 1
metastatic melanoma 1
Autism 1
ovarian neoplasm 1
non-Hodgkin's lymphoma 1
CHN 1
more...
Symptom
starvation 3
seizures 2
functional recovery 2
hypothermia 1
hypercapnia 1
hyperoxia 1
pain 1
headache 1
neuralgia 1
erythema 1
Drug
ROS 14
lysine 8
MAP 6
IFN-gamma 4
Arsenic trioxide 4
Taxol 3
IL-2 3
Sorafenib 3
AMC 2
IFN-beta 2
ICI 2
ZnO 2
Dermatol 2
NVP 2
Fulvestrant 1
Cardiovasc 1
Compound 18 1
CPT-11 1
Estrogens 1
CTX 1
Clopidogrel 1
Rituximab 1
Spiegel 1
Nephron 1
vitamin E 1
K-252a 1
Biopolymers 1
Adriamycin 1
Glycyrrhiza 1
TFT 1
Nitric Oxide 1
Monensin 1
Lovastatin 1
FAD 1
Purvalanol 1
Amiloride 1
Ketoconazole 1
Monit 1
Silica gel 1
Epigallocatechin 1
PFT 1
TTC 1
Nephron 1
Parkin 1
Pravastatin 1
Phosphatidylserine 1
Rosiglitazone 1
CSF 1
Propofol 1
caffeine 1
-deoxyadenosine 1
Parkin 1
Simvastatin 1
Asn 1
Herceptin 1
Fragment 1
Bortezomib 1
Propidium 1
ADR 1
Enzyme
caspase-7 896
caspase-7 896
caspase-3 532
caspase-9 225
PARP 172
caspase-8 138
mitogen-activated protein kinase 75
caspase-6 68
caspase-6 68
caspase-1 46
caspase-2 38
caspase-2 38
ERK 34
protein kinase 18
proteasome 14
MEK 14
cdc2 12
protein kinase C 12
caspase-4 11
granzyme B 11
caspase-4 11
focal adhesion kinase 10
catalase 9
superoxide dismutase 9
lactate dehydrogenase 7
ACS 6
MAP 6
GSK 5
glutathione peroxidase 5
caspase-10 5
glutathione S-transferase 5
caspase-10 5
glutathione reductase 4
AMP-activated protein kinase 4
RNase 4
aspartate aminotransferase 4
endonuclease 4
alanine aminotransferase 4
ATPase 4
luciferase 4
trypsin 4
NADPH oxidase 4
caspase-11 3
calcineurin 3
NADPH oxidase 3
thrombin 3
DNase 3
cathepsin G 3
RNase 3
myosin light chain kinase 3
elastase 3
ECH 3
creatine kinase 3
cathepsin D 3
m-calpain 3
phospholipase C 3
Omi/HtrA2 3
topoisomerase 3
phosphoinositide 3-kinase 3
caspase-11 3
topoisomerase 3
reverse transcriptase 3
AMPK 2
NQO1 2
P-glycoprotein 2
thymidylate synthase 2
succinate dehydrogenase 2
complex I 2
CAD 2
CAD 2
DNA methyltransferase 2
DNA polymerase 2
caspase-5 2
sphingosine kinase 2
IKK 2
CAD 2
prolyl hydroxylase 2
mu-calpain 2
peroxiredoxin 2
AMPK 2
aspartase 2
cathepsin B 2
legumain 2
caspase-5 2
cathepsin L 1
demethylase 1
cathepsin C 1
polo-like kinase 1 1
ACE 1
ribonuclease 1
deoxycytidine kinase 1
MEKK1 1
firefly luciferase 1
RNase T1 1
neutrophil elastase 1
PTPase 1
ribonuclease 1
SNO 1
MAT 1
glyceraldehyde-3-phosphate dehydrogenase 1
lysozyme 1
beta-glucosidase 1
beta-glucosidase 1
AST 1
subtilisin 1
APC 1
Tpa 1
lipase 1
urokinase-type plasminogen activator 1
prostate-specific antigen 1
MAT 1
TSP-1 1
stromelysin-3 1
Alternating 1
ALDH 1
PHT 1
arginase 1
thermolysin 1
MDR 1
collagenase 1
monoamine oxidase 1
diamine oxidase 1
phosphatidylinositol 3-kinase 1
acetylcholinesterase 1
peroxidase 1
TdT 1
HSD 1
lipoxygenase 1
MPP 1
cathepsin K 1
chitinase 1
adenosine kinase 1
Compound
DNA 152
Dec 74
oxygen 69
cysteine 41
Asp 38
MDA 34
MTT 33
ADP-ribose 26
glucose 23
TNF 23
calcium 20
ADP 18
iodine 17
ATP 16
dUTP 16
ADP 16
ADP 16
tyrosine 15
alanine 14
bromide 13
sodium 13
serine 12
hydrogen 10
MEK 10
N-acetylcysteine 10
lysine 9
Hoechst 33342 8
water 8
acridine 8
zinc 8
Clin 8
aldehyde 7
GSH 7
aspartic acid 7
ethyl acetate 7
aspartic acid 7
boron 7
aspartic acid 7
aldehyde 7
aspartic acid 7
dATP 7
GSH 7
MAP 6
ethanol 6
nitrogen 6
ACS 6
ACS 6
glutamate 6
copper 5
Acrolein 5
ASC 5
threonine 5
Curcumin 5
chalcone 5
MTS 5
leucine 5
kaempferol 5
galactose 4
DDP 4
Cytochrome c 4
ATF 4
H2O2 4
NH2 4
phosphate 4
arginine 4
Paclitaxel 4
glutamic acid 4
DMSO 3
selenium 3
COS 3
valine 3
Cer 3
sulfate 3
Isoliquiritigenin 3
acetate 3
indole-3-carbinol 3
Cordycepin 3
iron 3
anthracene 3
NAD 3
NADPH 3
methionine 3
glutamine 3
Phe 3
Cordycepin 3
potassium 3
Cordycepin 3
Melatonin 3
NADPH 3
5-FU 3
pyrene 2
retinoic acid 2
Staurosporine 2
salt 2
Panam 2
benzene 2
DMI 2
Rottlerin 2
Adriamycin 2
5-HETE 2
Estrogen 2
ammonium 2
THP 2
naphthoquinone 2
AMP 2
nickel 2
methanol 2
Rottlerin 2
ICI 2
Oridonin 2
naphthoquinone 2
THP 2
silver 2
ABL 2
Propofol 2
COX 2
Rottlerin 2
fluorine 2
HMG-CoA 2
DBA 2
NAD 2
Neuronal 2
TNM 2
tert-butyl hydroperoxide 2
ADR 2
Wortmannin 2
CO2 2
Estrogen 2
Pac 2
His 2
naphthoquinone 2
naphthoquinone 2
DMI 2
cyanide 2
naphthoquinone 2
naphthalene 2
XTT 2
pyridine 2
MSM 2
DPPH 2
C-3 2
Foscan 2
BCR 2
nitric oxide 2
naphthoquinone 2
acetic acid 2
PEG 2
Ribose 2
DMS 2
Quercetin 2
VP-16 2
naphthoquinone 2
cGMP 2
Staurosporine 2
Ile 2
Lac 1
Geldanamycin 1
DNP 1
Dexamethasone 1
Acacetin 1
more...