Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.B10 (
caspase-7
)
896
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Numerous solid tumors and
hematologic malignancies
acquire resistance to apoptosis-inducing chemotherapeutic drugs by downregulating the key effector caspase-3. These cells rely on
caspase-7
to execute the apoptotic program, yet binding with XIAP constitutively inhibits active
caspase-7
(p19/p12-CASP7). In this issue, Lin et al. describe how a newly synthesized drug is able to disrupt the XIAP:p19/p12-CASP7 complex and induce apoptosis in caspase-3-deficient cancer cells in vitro and in vivo. As this compound appears to exhibit minimal toxicity on normal tissues, it may represent a promising therapeutic agent to help treat caspase-3-deficient tumors.
...
PMID:Unshackling caspase-7 for cancer therapy. 2397 66
