Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.65 (
Der p 1
)
346
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gamma-interferon-inducible lysosomal thiol reductase
(
GILT
) is known to reduce disulfide bonds present in proteins internalized by antigen presenting cells, facilitating optimal processing and presentation of peptides on Major Histocompatibility Complex class II molecules, as well as the subsequent activation of CD4-positive T lymphocytes. Here, we show that
GILT
is required for class II-restricted processing and presentation of immunodominant epitopes from the major house dust mite
allergen Der p 1
. In the absence of
GILT
, CD4-positive T cell responses to
Der p 1
are significantly reduced, resulting in mitigated allergic airway inflammation in response to
Der p 1
and house dust mite extracts in a murine model of asthma.
...
PMID:MHC class II-restricted presentation of the major house dust mite allergen Der p 1 Is GILT-dependent: implications for allergic asthma. 2332 13
