Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.65 (
Der p 1
)
346
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The house dust mite Dermatophagoides pteronyssinus
allergen Der p 1
is the most immunodominant allergen involved in the expression of dust mite-specific immunoglobulin (Ig)E-mediated hypersensitivity. The reason for this potent IgE-eliciting property of
Der p 1
remains unknown, but there is mounting in vitro evidence linking the allergenicity of
Der p 1
to its cysteine protease activity. Here we demonstrate for the first time that immunization of mice with proteolytically active
Der p 1
results in a significant enhancement in total IgE and
Der p 1
-specific IgE synthesis compared with animals immunized with
Der p 1
that was irreversibly blocked with the cysteine protease inhibitor
E-64
. We conclude that the proteolytic activity of
Der p 1
is a major contributor to its allergenicity.
...
PMID:The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response. 1060 64
