Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.62 (
caspase-9
)
7,507
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
caspase-9
7493
caspase-3
4758
Bcl-2
2524
cytochrome c
2176
caspase-8
2021
p53
955
PARP
889
Mol
657
Sep
541
Fas
524
Bid
436
Apaf-1
414
annexin V
403
cytochrome
391
p21
335
ROS
319
p38
317
poly(ADP-ribose) polymerase
308
JNK
286
tumor necrosis factor
262
endoplasmic reticulum
255
superoxide dismutase
246
TNF
245
GSH
220
Bak
219
poly (ADP-ribose) polymerase
218
ATP
217
PI3K
212
XIAP
211
ERK
210
AKT
199
catalase
193
Smac
187
MAPK
179
cyclin D1
172
bcl-2
169
Mcl-1
167
ERK1
151
survivin
151
FasL
148
apoptosis-inducing factor
148
bax
146
inhibitor of apoptosis
140
anti-apoptotic protein
134
c-Jun
131
DIABLO
130
Fas ligand
127
p27
126
cytokine
125
mTOR
123
lactate dehydrogenase
122
Bax protein
121
cyclin B1
112
Bcl-X
111
IL-6
109
glutathione peroxidase
108
BAX
105
FADD
105
extracellular signal-regulated kinase
99
p65
96
TRAIL
95
inducible nitric oxide synthase
93
AIF
92
CD95
90
SOD
90
LC3
89
pro-apoptotic protein
88
proteasome
87
calpain
85
cyclin E
84
cyclin A
83
PARP-1
80
kit
80
PC-3
80
osteosarcoma
79
ADP
77
DR5
73
Cytochrome c
73
CHOP
73
CDK4
72
more...
Disease
cancer
2062
tumor
1204
breast cancer
387
leukemia
342
MCF
315
hepatocellular carcinoma
291
tumor growth
283
carcinoma
271
GSH
220
lung cancer
207
colon cancer
190
B-cell lymphoma
177
prostate cancer
175
melanoma
172
ischemia
161
neuroblastoma
139
adenocarcinoma
129
colorectal cancer
118
gastric cancer
115
carcinogenesis
108
non-small cell lung cancer
104
lymphoma
104
tumorigenesis
94
Alzheimer's disease
93
glioma
91
squamous cell carcinoma
91
Parkinson's disease
90
multiple myeloma
87
ovarian cancer
86
cervical cancer
86
osteosarcoma
84
diabetes
77
liver cancer
74
glioblastoma
67
acute myeloid leukemia
62
pancreatic cancer
57
liver cancer
57
cerebral ischemia
54
acute promyelocytic leukemia
53
lung carcinoma
47
chronic myeloid leukemia
47
atherosclerosis
45
suicide
45
tumor progression
44
oral cancer
40
DDP
40
bladder cancer
38
renal cell carcinoma
38
myocardial ischemia
37
stroke
36
ATM
34
AGS
33
hyperglycemia
32
Leukemia
32
virus infection
31
rheumatoid arthritis
30
SCID
30
skin cancer
30
sepsis
30
sepsis
29
acute lymphoblastic leukemia
28
HIV
28
FAS
28
infectious diseases
27
brain tumor
27
pheochromocytoma
25
myocardial infarction
25
MTS
25
metastases
24
myeloid leukemia
24
epithelial ovarian cancer
23
retinoblastoma
22
NAME
21
Hepatocellular carcinoma
21
esophageal cancer
21
Blocking
21
cognitive impairment
20
heart failure
20
chronic lymphocytic leukemia
20
cardiovascular disease
19
more...
Symptom
collapse
98
starvation
30
seizures
17
functional recovery
13
diarrhea
12
pain
12
anesthesia
10
hyperoxia
6
respiratory distress
6
hypothermia
5
memory loss
4
acidity
3
cough
3
weakness
3
skin damage
3
headache
3
vomiting
3
bradykinesia
3
abdominal pain
3
tremor
2
neurological disability
2
dyspnea
2
cachexia
2
angina
2
thinning
2
analgesia
2
halitosis
2
nausea
2
loss of balance
1
male subfertility
1
back pain
1
menopausal symptoms
1
Motor dysfunction
1
sore throat
1
erythema
1
infant diarrhea
1
incoordination
1
low back pain
1
dry eye
1
dizziness
1
Anoxia
1
fatigue
1
nasal discharge
1
despair
1
hyperemesis
1
not coping
1
Neuropathic pain
1
tinnitus
1
Catch
1
Tenderness
1
exhaustion
1
HSA
1
nausea and vomiting
1
Drug
ROS
319
vitamin E
34
Monit
33
ascorbate
29
Arsenic trioxide
19
Cardiovasc
17
ADR
16
Taxol
15
MAP
15
Dermatol
14
Emodin
14
IL-2
14
Emodin
14
IFN-gamma
13
CED
13
lysine
13
caffeine
12
CTX
12
Bortezomib
12
Etoposide
11
CTX
10
Ethanol
10
CTX
10
Glycyrrhiza
10
Propofol
10
MRC
9
NADH
9
Parkin
9
p75
9
-deoxyadenosine
9
CSF
9
Parkin
9
AMC
8
Gel
8
Vitamin E
8
Glutathione
8
Sorafenib
7
ALA
7
Ginseng
7
PFT
7
Indomethacin
7
Mutagen
6
Flavopiridol
6
Heme
6
NVP
6
TTC
6
Epigallocatechin
6
ZnO
6
Gefitinib
6
lactose
5
ICI
5
CPT-11
5
ADM
5
TAT
5
IFN-beta
4
Docetaxel
4
BH4
4
3-Methyladenine
4
Cantor
4
Fluorescein
4
Rituximab
4
Swainsonine
4
Silica
4
Simvastatin
4
Bromelain
4
Growth hormone
3
Onconase
3
Photofrin
3
Raloxifene
3
Tacrolimus
3
CCL
3
TiO2
3
Retinoic acid
3
EE2
3
Growth hormone
3
2-Methoxyestradiol
3
Gleevec
3
Isoniazid
3
Nitric Oxide
3
Adriamycin
3
more...
Enzyme
caspase-9
7507
caspase-3
4691
caspase-8
1965
PARP
966
mitogen-activated protein kinase
721
superoxide dismutase
325
ERK
275
catalase
232
caspase-7
228
caspase-7
225
protein kinase
211
caspase-2
166
caspase-2
165
lactate dehydrogenase
125
glutathione peroxidase
109
caspase-6
97
caspase-6
96
proteasome
89
cdc2
88
MEK
85
luciferase
80
caspase-1
76
protein kinase C
75
focal adhesion kinase
75
alanine aminotransferase
66
phosphatidylinositol 3-kinase
66
GSK
63
aspartate aminotransferase
58
caspase-4
46
caspase-4
46
AMP-activated protein kinase
43
caspase-10
43
caspase-10
41
ATPase
37
peroxidase
36
MMP
36
TdT
33
P-glycoprotein
31
phosphoinositide 3-kinase
31
Omi/HtrA2
29
glutathione S-transferase
29
NADPH oxidase
28
complex I
28
calcineurin
27
topoisomerase
27
NADPH oxidase
25
glutathione reductase
25
topoisomerase
24
alkaline phosphatase
23
AMPK
23
MPP
22
AMPK
22
cathepsin B
22
AST
22
creatine kinase
20
acetylcholinesterase
18
ACS
17
reverse transcriptase
17
tyrosine hydroxylase
17
DNase
16
NO synthase
16
RNase
16
IKK
16
RNase
16
cathepsin D
15
succinate dehydrogenase
15
MAP
13
cytochrome oxidase
12
mu-calpain
12
NQO1
12
granzyme B
12
CAD
11
phospholipase C
11
m-calpain
11
PDK1
11
CAD
11
CAD
11
endonuclease
10
ribonuclease
9
ribonuclease
9
more...
Compound
DNA
1451
oxygen
1233
Dec
568
MTT
567
cysteine
246
TNF
245
GSH
227
GSH
227
ATP
217
calcium
210
MDA
210
iodine
208
dUTP
185
N-acetylcysteine
169
ADP-ribose
160
glucose
157
bromide
152
hydrogen
151
water
148
Asp
138
nitric oxide
128
Cyt
97
Clin
96
sodium
96
alanine
95
ADP
94
H2O2
85
serine
81
ADP
77
ADP
77
Cytochrome c
73
ethanol
73
boron
73
dATP
68
threonine
61
DDP
57
tyrosine
56
acridine
54
Hoechst 33342
53
zinc
52
Curcumin
49
phosphate
49
cadmium
49
MEK
48
Panam
45
selenium
43
leucine
43
nitrogen
42
retinoic acid
42
galactose
41
ADR
41
CAT
40
CAT
40
CAT
40
glutamate
39
ethyl acetate
39
acetate
38
copper
38
THP
38
THP
38
His
37
iron
33
arginine
33
NH2
32
urea
31
sulfate
31
Adriamycin
30
creatinine
29
chalcone
28
anthracene
27
Resveratrol
27
aldehyde
26
NAD
25
aldehyde
25
MTS
25
salt
24
diacetate
24
methanol
23
GSSG
23
MPP
22
more...