Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.62 (caspase-9)
 7,507 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-9 7493
caspase-3 4758
Bcl-2 2524
cytochrome c 2176
caspase-8 2021
p53 955
PARP 889
Mol 657
Sep 541
Fas 524
Bid 436
Apaf-1 414
annexin V 403
cytochrome 391
p21 335
ROS 319
p38 317
poly(ADP-ribose) polymerase 308
JNK 286
tumor necrosis factor 262
endoplasmic reticulum 255
superoxide dismutase 246
TNF 245
GSH 220
Bak 219
poly (ADP-ribose) polymerase 218
ATP 217
PI3K 212
XIAP 211
ERK 210
AKT 199
catalase 193
Smac 187
MAPK 179
cyclin D1 172
bcl-2 169
Mcl-1 167
ERK1 151
survivin 151
apoptosis-inducing factor 148
FasL 148
bax 146
inhibitor of apoptosis 140
anti-apoptotic protein 134
c-Jun 131
DIABLO 130
Fas ligand 127
p27 126
cytokine 125
mTOR 123
lactate dehydrogenase 122
Bax protein 121
cyclin B1 112
Bcl-X 111
IL-6 109
glutathione peroxidase 108
FADD 105
BAX 105
extracellular signal-regulated kinase 99
p65 96
TRAIL 95
inducible nitric oxide synthase 93
AIF 92
CD95 90
SOD 90
LC3 89
pro-apoptotic protein 88
proteasome 87
calpain 85
cyclin E 84
cyclin A 83
PC-3 80
PARP-1 80
kit 80
osteosarcoma 79
ADP 77
Cytochrome c 73
CHOP 73
DR5 73
CDK4 72
X-linked inhibitor of apoptosis protein 72
cyclin 69
GRP78 67
proliferating cell nuclear antigen 67
p38 mitogen-activated protein kinase 66
phosphatidylinositol 3-kinase 66
CDK2 66
mitogen-activated protein 64
MMP-9 64
LDH 61
Nrf2 60
TNF-alpha 59
GSK 59
cIAP2 58
catenin 58
BID 58
endonuclease G 57
COX-2 57
lipopolysaccharide 55
STAT3 53
CCK 52
protein kinase B 52
IAP 52
HSP70 52
MEK 51
ubiquitin 51
histone deacetylase 51
DR4 50
interleukin-6 48
C/EBP homologous protein 47
NAC 47
heme oxygenase-1 47
VEGF 47
proteasome inhibitor 46
collagen 46
insulin 46
cyclooxygenase-2 46
SGC 45
IL-10 44
erythroid 44
Beclin-1 44
CDK1 44
cyclin-dependent kinase 44
NMR 44
BAD 43
histone 43
PUMA 43
c-FLIP 43
vascular endothelial growth factor 42
PTEN 42
MMP-2 42
epidermal growth factor receptor 41
CAT 40
tyrosine kinase 40
TdT 40
c-Myc 40
antioxidant enzyme 39
aspartate aminotransferase 39
PC3 38
estrogen receptor 38
FLIP 38
THP 38
colon carcinoma 38
alanine aminotransferase 36
HO-1 36
Tumor necrosis factor 36
MMP 36
matrix metalloproteinase 36
JNK1 35
cyclin dependent kinase 35
IFN 35
WAF1 34
PERK 34
IL-8 34
ATPase 34
AGS 33
interacting protein 33
p62 33
PKC 32
interferon 32
more...
Disease
cancer 2062
tumor 1204
breast cancer 387
leukemia 342
MCF 315
hepatocellular carcinoma 291
tumor growth 283
carcinoma 271
GSH 220
lung cancer 207
colon cancer 190
B-cell lymphoma 177
prostate cancer 175
melanoma 172
ischemia 161
neuroblastoma 139
adenocarcinoma 129
colorectal cancer 118
gastric cancer 115
carcinogenesis 108
lymphoma 104
non-small cell lung cancer 104
tumorigenesis 94
Alzheimer's disease 93
squamous cell carcinoma 91
glioma 91
Parkinson's disease 90
multiple myeloma 87
ovarian cancer 86
cervical cancer 86
osteosarcoma 84
diabetes 77
liver cancer 74
glioblastoma 67
acute myeloid leukemia 62
liver cancer 57
pancreatic cancer 57
cerebral ischemia 54
acute promyelocytic leukemia 53
chronic myeloid leukemia 47
lung carcinoma 47
atherosclerosis 45
suicide 45
tumor progression 44
oral cancer 40
DDP 40
renal cell carcinoma 38
bladder cancer 38
myocardial ischemia 37
stroke 36
ATM 34
AGS 33
hyperglycemia 32
Leukemia 32
virus infection 31
SCID 30
rheumatoid arthritis 30
skin cancer 30
sepsis 30
sepsis 29
acute lymphoblastic leukemia 28
FAS 28
HIV 28
infectious diseases 27
brain tumor 27
pheochromocytoma 25
MTS 25
myocardial infarction 25
metastases 24
myeloid leukemia 24
epithelial ovarian cancer 23
retinoblastoma 22
esophageal cancer 21
Hepatocellular carcinoma 21
Blocking 21
NAME 21
cognitive impairment 20
chronic lymphocytic leukemia 20
heart failure 20
cardiovascular disease 19
osteoporosis 19
Melanoma 19
Huntington's disease 18
esophageal cancer 18
solid tumor 18
type 2 diabetes 17
Glioblastoma 17
glioblastoma multiforme 16
depression 16
Pineal 16
Hodgkin's disease 16
sarcoma 16
Osteosarcoma 16
Osteosarcoma 16
Burkitt's lymphoma 16
Infection 16
chronic lymphocytic leukemia 15
plaque 15
CEM 15
fibrosarcoma 15
renal disease 15
coronary artery disease 14
asthma 14
NOD 14
osteoarthritis 14
Neuroblastoma 13
herpes simplex 13
hepatitis B 13
hepatitis C 13
rhabdomyosarcoma 13
Neuroblastoma 13
tuberculosis 13
diabetic nephropathy 12
small cell lung cancer 12
cold 12
metastatic melanoma 12
cardiomyopathy 12
endometrial cancer 12
SDS 12
dementia 12
mantle cell lymphoma 11
Nasopharyngeal carcinoma 11
liver fibrosis 11
amyotrophic lateral sclerosis 11
memory impairment 11
Mycobacterium 11
multiple sclerosis 11
TEM 11
pneumonia 11
HCC 11
obesity 11
colitis 11
parkinsonism 11
Wright 11
inflammatory bowel disease 11
heart disease 11
TEM 11
lymphoblastic leukemia 11
arthritis 10
cataract 10
ARC 10
acute leukemia 10
epilepsy 10
CTX 10
influenza 10
AIDS 9
renal cancer 9
immunodeficiency 9
pulmonary fibrosis 9
liver disease 9
Ewing's sarcoma 9
tumor angiogenesis 9
fatty liver 9
medulloblastoma 9
renal ischemia 9
hepatitis 9
ulcerative colitis 9
encephalitis 9
HOS 9
bacterial infection 9
more...
Symptom
collapse 98
starvation 30
seizures 17
functional recovery 13
diarrhea 12
pain 12
anesthesia 10
hyperoxia 6
respiratory distress 6
hypothermia 5
memory loss 4
acidity 3
cough 3
weakness 3
skin damage 3
headache 3
vomiting 3
bradykinesia 3
abdominal pain 3
tremor 2
neurological disability 2
dyspnea 2
cachexia 2
angina 2
thinning 2
analgesia 2
halitosis 2
nausea 2
loss of balance 1
male subfertility 1
back pain 1
menopausal symptoms 1
Motor dysfunction 1
sore throat 1
erythema 1
infant diarrhea 1
incoordination 1
low back pain 1
dry eye 1
dizziness 1
Anoxia 1
fatigue 1
nasal discharge 1
despair 1
hyperemesis 1
not coping 1
Neuropathic pain 1
tinnitus 1
Catch 1
Tenderness 1
exhaustion 1
HSA 1
nausea and vomiting 1
Drug
ROS 319
vitamin E 34
Monit 33
ascorbate 29
Arsenic trioxide 19
Cardiovasc 17
ADR 16
MAP 15
Taxol 15
IL-2 14
Dermatol 14
Emodin 14
Emodin 14
CED 13
IFN-gamma 13
lysine 13
caffeine 12
CTX 12
Bortezomib 12
Etoposide 11
Propofol 10
CTX 10
CTX 10
Glycyrrhiza 10
Ethanol 10
p75 9
Parkin 9
CSF 9
MRC 9
Parkin 9
-deoxyadenosine 9
NADH 9
Gel 8
Vitamin E 8
Glutathione 8
AMC 8
PFT 7
ALA 7
Indomethacin 7
Ginseng 7
Sorafenib 7
TTC 6
NVP 6
Heme 6
Mutagen 6
ZnO 6
Flavopiridol 6
Epigallocatechin 6
Gefitinib 6
lactose 5
CPT-11 5
ICI 5
TAT 5
ADM 5
BH4 4
Docetaxel 4
Rituximab 4
Silica 4
IFN-beta 4
Fluorescein 4
3-Methyladenine 4
Simvastatin 4
Cantor 4
Bromelain 4
Swainsonine 4
EE2 3
2-Methoxyestradiol 3
Photofrin 3
TiO2 3
CCL 3
Tacrolimus 3
Onconase 3
Retinoic acid 3
Angiotensin II 3
Estrogens 3
Red ginseng 3
G418 3
Growth hormone 3
Raloxifene 3
Nitric Oxide 3
Adriamycin 3
Imatinib 3
Growth hormone 3
Fluorescein 3
Isoniazid 3
Gleevec 3
Nephron 3
Irinotecan 2
Doxycycline 2
Erlotinib 2
TRM 2
Fludarabine 2
Activin 2
Leaf 2
Glucagon 2
CoCl2 2
Vitamin K 2
Bifidobacterium 2
Biopolymers 2
Gelatin 2
Nephron 2
Lexatumumab 2
CoCl2 2
CA-074 2
Sodium nitroprusside 2
G-CSF 2
Dasatinib 2
Triclosan 2
Hyperforin 2
Crotonaldehyde 2
Riboflavin 2
Colistin 2
Alanine 2
Adenosine triphosphate 2
Silica gel 2
Fraction 2
Rutin 2
Amiloride 2
CAM 2
Vinorelbine 2
Nimesulide 2
OTC 2
NBT 2
Imiquimod 2
Oxaliplatin 2
DNase I 2
Artesunate 2
OTC 2
Fipronil 2
Dial 2
Propidium 2
DEX 2
ABC 1
Portal 1
Alexidine 1
SNL 1
Monensin 1
Cidofovir 1
ENT 1
Apomorphine 1
Calcium chloride 1
THA 1
PCB 1
Iodixanol 1
Proflavin 1
Compound 19 1
Verteporfin 1
Zoledronic acid 1
Compound 15 1
Levosimendan 1
Thioridazine 1
Pralatrexate 1
Lead acetate 1
DMAP 1
Glutamic acid 1
Ouabain 1
Rauwolfia serpentina 1
Cupric sulfate 1
VCR 1
Lenalidomide 1
more...
Enzyme
caspase-9 7507
caspase-3 4691
caspase-8 1965
PARP 966
mitogen-activated protein kinase 721
superoxide dismutase 325
ERK 275
catalase 232
caspase-7 228
caspase-7 225
protein kinase 211
caspase-2 166
caspase-2 165
lactate dehydrogenase 125
glutathione peroxidase 109
caspase-6 97
caspase-6 96
proteasome 89
cdc2 88
MEK 85
luciferase 80
caspase-1 76
protein kinase C 75
focal adhesion kinase 75
alanine aminotransferase 66
phosphatidylinositol 3-kinase 66
GSK 63
aspartate aminotransferase 58
caspase-4 46
caspase-4 46
AMP-activated protein kinase 43
caspase-10 43
caspase-10 41
ATPase 37
MMP 36
peroxidase 36
TdT 33
phosphoinositide 3-kinase 31
P-glycoprotein 31
glutathione S-transferase 29
Omi/HtrA2 29
complex I 28
NADPH oxidase 28
calcineurin 27
topoisomerase 27
NADPH oxidase 25
glutathione reductase 25
topoisomerase 24
alkaline phosphatase 23
AMPK 23
AST 22
AMPK 22
MPP 22
cathepsin B 22
creatine kinase 20
acetylcholinesterase 18
reverse transcriptase 17
tyrosine hydroxylase 17
ACS 17
DNase 16
NO synthase 16
IKK 16
RNase 16
RNase 16
cathepsin D 15
succinate dehydrogenase 15
MAP 13
granzyme B 12
cytochrome oxidase 12
NQO1 12
mu-calpain 12
phospholipase C 11
PDK1 11
m-calpain 11
CAD 11
CAD 11
CAD 11
endonuclease 10
ribonuclease 9
ribonuclease 9
MMP-3 8
caspase-11 8
peroxiredoxin 8
trypsin 8
ECH 8
MEKK1 8
caspase-11 8
protein phosphatase 2A 8
collagenase 8
heme oxygenase 7
neutral sphingomyelinase 7
DNA ligase 7
thymidine kinase 7
DNA ligase 7
myosin light chain kinase 7
NOS 7
urokinase-type plasminogen activator 7
prostate-specific antigen 6
ATP synthase 6
phosphodiesterase 6
farnesyltransferase 6
farnesyltransferase 6
sphingosine kinase 6
aconitase 6
paraoxonase 6
xanthine oxidase 6
gamma-glutamyl transpeptidase 5
factor C 5
carbonic anhydrase 5
TAT 5
thioredoxin reductase 5
TOR 5
renin 5
RNA polymerase 5
neutrophil elastase 5
guanylate cyclase 5
thrombin 5
DNA methyltransferase 5
DCF 5
gamma-glutamylcysteine synthetase 5
lysozyme 5
arginase 4
ornithine decarboxylase 4
caspase-5 4
acid phosphatase 4
choline acetyltransferase 4
cholinesterase 4
cysteine synthase 4
ACE 4
monoamine oxidase 4
polo-like kinase 1 4
beta-galactosidase 4
bromelain 4
glyceraldehyde-3-phosphate dehydrogenase 4
ricin 4
APC 4
neuraminidase 4
adenosine kinase 3
pyruvate dehydrogenase 3
HCS 3
apyrase 3
DNA polymerase 3
malate dehydrogenase 3
15-lipoxygenase 3
3-hydroxy-3-methylglutaryl-CoA reductase 3
acetyl-CoA carboxylase 3
glyceraldehyde-3-phosphate dehydrogenase 3
glyceraldehyde-3-phosphate dehydrogenase 3
MDR 3
hyaluronidase 3
aspartase 3
pyruvate dehydrogenase 3
pyruvate dehydrogenase 3
PKG 3
glyceraldehyde-3-phosphate dehydrogenase 3
CaMKII 3
transcriptase 3
sialyltransferase 3
ADP-ribosyltransferase 3
firefly luciferase 3
more...
Compound
DNA 1451
oxygen 1233
Dec 568
MTT 567
cysteine 246
TNF 245
GSH 227
GSH 227
ATP 217
MDA 210
calcium 210
iodine 208
dUTP 185
N-acetylcysteine 169
ADP-ribose 160
glucose 157
bromide 152
hydrogen 151
water 148
Asp 138
nitric oxide 128
Cyt 97
Clin 96
sodium 96
alanine 95
ADP 94
H2O2 85
serine 81
ADP 77
ADP 77
boron 73
ethanol 73
Cytochrome c 73
dATP 68
threonine 61
DDP 57
tyrosine 56
acridine 54
Hoechst 33342 53
zinc 52
Curcumin 49
phosphate 49
cadmium 49
MEK 48
Panam 45
leucine 43
selenium 43
nitrogen 42
retinoic acid 42
ADR 41
galactose 41
CAT 40
CAT 40
CAT 40
ethyl acetate 39
glutamate 39
acetate 38
THP 38
copper 38
THP 38
His 37
iron 33
arginine 33
NH2 32
sulfate 31
urea 31
Adriamycin 30
creatinine 29
chalcone 28
anthracene 27
Resveratrol 27
aldehyde 26
NAD 25
MTS 25
aldehyde 25
diacetate 24
salt 24
GSSG 23
methanol 23
ATF 22
Ile 22
manganese 22
MPP 22
MPP 22
naphthoquinone 21
NAD 21
Pac 21
naphthoquinone 21
naphthoquinone 21
Neuronal 21
naphthoquinone 21
naphthoquinone 21
naphthoquinone 21
naphthoquinone 21
methionine 20
potassium 20
Phe 20
5-FU 20
kaempferol 20
gallic acid 20
DMSO 19
Melatonin 19
PEG 19
Oridonin 19
lysine 18
Emodin 18
nicotinamide 18
ACS 17
nickel 17
NOXA 17
Rotenone 17
pyrrolidine 17
ACS 17
hexane 16
MPTP 16
pyrrolidine 16
AMP 16
TEM 16
VP-16 15
Taurine 15
Berberine 15
Quercetin 15
DPPH 14
Baicalein 14
homocysteine 14
Emodin 14
cobalt 14
APAP 14
ammonium 13
Gly 13
proline 13
Ursolic acid 13
cAMP 13
8-OHdG 13
DBA 13
MAP 13
PEG 13
Insulin 12
Matrine 12
glutamine 12
caffeine 12
fluorine 12
aspartic acid 12
Matrine 12
aspartic acid 12
indole-3-carbinol 12
phosphocreatine 12
Matrine 12
SDS 12
CTX 12
pyrene 12
isoquinoline 12
silver 11
H2S 11
Cereb 11
pyridine 11
Vitamin E 11
aspartic acid 11
Hematoxylin 11
benzene 11
more...