Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.62 (
caspase-9
)
7,507
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Here, we report the identification of
GIDE
, a mitochondrially located E3 ubiquitin ligase.
GIDE
contains a C-terminal RING finger domain, which is mostly conserved with those of the IAP family members and is required for
GIDE
's E3 ligase activity. Overexpression of
GIDE
induces apoptosis via a pathway involving activation of caspases, since caspase inhibitors, XIAP and an inactive mutant of
caspase-9
block
GIDE
-induced apoptosis.
GIDE
also activates JNK, and blockage of JNK activation inhibits
GIDE
-induced release of cytochrome c and Smac as well as apoptosis, suggesting that JNK activation precedes release of cytochrome c and Smac and is required for
GIDE
-induced apoptosis. These pro-apoptotic properties of
GIDE
require its E3 ligase activity. When somewhat over- or underexpressed,
GIDE
slows or accelerates cell growth, respectively. These pro-apoptotic or growth inhibition effects of
GIDE
may account for its absence in tumor cells.
...
PMID:GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. 1859 63
