Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.62 (
caspase-9
)
7,507
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cytochrome c (CYT c) is a protein that employs the caspase recruitment domain (CARD)-containing proteins APAF-1 and
CASP-9
to activate effectors CASP-3 and -7. By using affinity labeling techniques and mass spectrometry analysis, we show that
histone H1.2
is a regulator of caspases upon UV irradiation. We demonstrated that
histone H1.2
forms a protein complex with APAF-1,
CASP-9
and CYT c upon UV irradiation. In cell-free systems, we show that
histone H1.2
triggers activation of CASP-3 and -7 via APAF-1 and
CASP-9
. We therefore conclude that upon DNA damage
histone H1.2
acts as a positive regulator of apoptosome formation.
...
PMID:Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9. 1761 26
