Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.62 (
caspase-9
)
7,507
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DICO
was a novel nonaromatic B-ring flavonoid obtained from Macrothelypteris torresiana. In the present work, we investigated the antitumor activity and the antineoplastic mechanism of
DICO
. Our study showed that
DICO
inhibited the growth of HepG2 cells in dose and time-dependent manners. As well as
DICO
induced G2/M cell cycle arrest and apoptosis via a ROS-mediated mitochondrial pathway. Western blot assay demonstrated that
DICO
decreased Bcl-2 level and induced Bax translocation to cause cytochrome c release. Subsequently,
caspase-9
and caspase-3 were activated. Meanwhile, the alterations of cyclin A and B1, p-CDK1 and p-cdc25c levels were also observed in response to
DICO
treatment. Taken together,
DICO
displayed a significant antitumor effect through G2/M cell cycle arrest and apoptosis induction, which suggested
DICO
might have therapeutic potential against tumors.
...
PMID:DICO, a novel nonaromatic B-ring flavonoid, induces G2/M cell cycle arrest and apoptosis in human hepatoma cells. 2356 43
