Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.61 (caspase-8)
 6,833 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Death associated protein 3 12.2
EFR3 homolog B 12.2
NADH-ubiquinone oxidoreductase B18 subunit 12.2
caspase and RIP adapter with death domain 12.2
caspase-8 11.8
G1/S-specific cyclin E2 11.2
Sal-like 4 (Drosophila) 11.2
Apoptotic peptidase activating factor 1 11.2
sorting nexin 7 11.2
C4orf22 11.2
FLICE 11.0
Fas-associated death domain protein 10.9
FADD 10.9
DEDD2 10.9
c-FLIP 10.7
Bid 10.6
EPH receptor B4 10.6
inhibitor of growth family, member 3 10.6
FLICE-associated huge protein 10.6
DOPEY1 10.6
PTPRK protein 10.6
TNFR1-associated death domain protein 10.3
FLIP 10.3
PMEPA1 protein 10.2
EFR3B 10.2
receptor (TNFRSF)-interacting serine-threonine kinase 1 10.2
BAP29 10.2
NUDT10 10.2
pFIV 10.2
uveal autoantigen with coiled-coil domains and ankyrin repeats 10.2
Squamous cell carcinoma antigen 1 10.2
CASP-9 10.0
death effector domain-containing 10.0
FAS-associated death domain protein 9.9
caspase-9 9.9
DFF35 9.9
CARD12 9.9
hRFI 9.9
GAGE-7 9.9
apolipoprotein L6 9.9
claudin 12 9.9
SH3RF2 9.9
ING3 protein 9.9
TNFRSF1A-associated via death domain 9.9
rosbin 9.9
claudin-12 9.8
death receptor 5 9.8
ICH-2 9.7
HIPPI 9.7
caspase 10 9.7
BH3 interacting domain death agonist 9.7
TRAIL-R2 9.7
FADD protein 9.7
RIPK3 9.6
RGPR-p117 9.6
cds2 9.6
SERP2 9.6
fucosyltransferase 3 9.6
G protein-coupled receptor 124 9.6
TMEM219 9.6
TRADD 9.5
CRADD 9.5
TNF-related apoptosis-inducing ligand 9.4
RIPK1 9.4
LASS5 9.4
CA-XIV 9.4
RAIDD 9.4
APBB1IP 9.4
longevity assurance gene 1 9.4
RIP-1 9.3
DcR1 9.3
Smac 9.3
TNF receptor-associated protein 9.3
RIP1 9.3
TRAIL-R1 9.3
p12 subunit 9.2
myc proto-oncogene protein 9.2
PYPAF7 9.2
ICEBERG 9.2
102kD 9.2
more...
Disease
LACH 10.6
HMN7B 10.2
Acute glaucoma 9.5
DFNB59 8.3
methionine synthase deficiency 8.2
autoimmune lymphoproliferative syndrome 8.0
AIDS cholangiopathy 7.8
Reovirus infection 7.7
Corneal infection 7.3
amok 7.1
AD5 7.0
KRS 7.0
salivary gland adenoid cystic carcinoma 6.9
salivary gland cancer 6.9
mouse leukemia P388 6.6
childhood rhabdomyosarcoma 6.6
VED 6.5
FAS 6.5
CYLD 6.4
salivary gland adenocarcinoma 6.4
Testicular Cancer 6.3
colon neoplasm 6.3
Cytokine storm 6.3
DFNA5 6.2
Epithelioma 6.1
Chronic beryllium disease 6.1
cowpox 6.0
Canine distemper 5.8
VES 5.8
molluscum contagiosum 5.8
Metastatic colorectal cancer 5.8
Aspergillus fumigatus infection 5.7
Tumour necrosis 5.7
Epidermolysis bullosa simplex 5.7
Mucolipidosis type IV 5.7
AGS 5.6
carbuncle 5.5
X-linked lymphoproliferative syndrome 5.5
retinal vascular occlusion 5.4
pediatric solid tumor 5.3
DRD 5.3
Oral infection 5.3
Neuroblastoma 5.2
Neuroblastoma 5.2
Barth syndrome 5.2
adrenal cancer 5.2
closed angle glaucoma 5.2
acute promyelocytic leukemia 5.2
ED3 5.2
Inverted papilloma 5.1
Askin tumor 5.1
Vesicular stomatitis 5.1
MCF 5.1
Photosensitization 5.1
CEM 5.1
cancer regression 5.0
LGL leukemia 5.0
Ileum 5.0
RP3 5.0
testicular dysfunction 5.0
Retinal ischemia 5.0
cervical adenocarcinoma 4.9
Glioblastoma 4.9
myeloid leukemia 4.9
Aeromonas hydrophila infection 4.9
Candida albicans infection 4.8
CM1 4.8
FGG 4.8
Keshan disease 4.8
mast cell leukemia 4.8
HEP 4.7
Acute liver failure 4.7
MTS 4.7
B-cell lymphoma 4.7
adrenocortical cancer 4.7
HOS 4.6
lymphomatoid granulomatosis 4.6
Mouse hepatitis 4.6
monocytic leukemia 4.6
colon cancer 4.6
more...
Symptom
bradypnea 4.5
hyperemesis 4.0
Tenderness 3.6
loss of balance 3.4
skin damage 3.2
ataxic gait 3.1
halitosis 3.0
collapse 2.8
hyperoxia 2.6
menopausal symptoms 2.5
dry eye 2.4
hot flashes 2.1
splenomegaly 2.1
memory loss 2.0
sore throat 1.8
starvation 1.7
hypothermia 1.6
functional recovery 1.5
alexithymia 1.4
cachexia 1.3
HSA 0.6
exhaustion 0.4
insomnia 0.4
thinning 0.3
acute stress 0.0
seizures -0.3
flushing -0.5
respiratory distress -0.5
myalgia -0.5
tinnitus -0.5
diarrhea -0.6
dystonia -0.9
tremor -1.0
syncope -1.0
nausea and vomiting -1.0
dizziness -1.1
low back pain -1.1
back pain -1.4
weakness -1.4
sleepiness -1.5
erythema -1.5
overweight -1.5
acidity -1.7
abdominal pain -1.7
ataxia -1.8
headache -2.0
anesthesia -2.2
discomfort -2.3
nausea -2.3
discomfort -2.4
dyspnea -2.6
pain -3.2
Drug
Edratide 12.2
2-Iminobiotin 9.6
Lexatumumab 9.6
Alexidine 9.2
Zedoary 8.9
Mapatumumab 8.9
Bear bile 8.7
Methadone hydrochloride 8.7
3,4-Dichloroisocoumarin 8.7
Cupric sulfate 8.2
Citrus unshiu peel 8.1
Naftopidil 7.9
Mevastatin 7.8
Radicicol 7.7
Avasimibe 7.6
Flavopiridol 7.5
Motexafin gadolinium 7.5
Sodium ascorbate 7.4
Berberine chloride 7.4
2-Methoxyestradiol 7.4
Irofulven 7.2
Lonafarnib 7.0
Ilomastat 6.9
Bucillamine 6.9
Peridinin 6.7
Olomoucine 6.7
Hyperforin 6.7
Trabectedin 6.6
Bortezomib 6.5
CED 6.5
CA-074 6.4
Nafamostat mesilate 6.2
Dextran sulfate sodium 6.1
Zebularine 6.1
Revlimid 6.1
Swainsonine 5.8
Rasburicase 5.7
Batimastat 5.7
Batimastat 5.7
Mizoribine 5.6
Onconase 5.4
Epigallocatechin 5.4
Compound 18 5.4
Vorinostat 5.3
Emodin 5.3
Thioridazine 5.3
Etodolac 5.2
Arsenic trioxide 5.2
Propidium 5.2
Cantor 5.2
ROS 5.2
RBT 5.0
ID2 5.0
Emodin 5.0
Etoposide 4.8
p75 4.8
Artesunate 4.8
Bromelain 4.7
Glycyrrhiza 4.7
Casodex 4.6
Cetrorelix 4.6
Taxol 4.5
Dasatinib 4.5
BLyS 4.5
Tranilast 4.5
ADR 4.5
Triad 4.5
Olmesartan 4.5
Bosentan 4.5
Bosentan 4.5
Rolipram 4.4
Sorafenib 4.4
Poloxamer 188 4.4
Calcium chloride 4.4
Triad 4.4
Spiegel 4.3
IFN-beta 4.3
Pirfenidone 4.3
NVP 4.3
PFT 4.3
more...
Enzyme
caspase-8 12.2
caspase-10 11.5
caspase-10 11.5
caspase-9 10.3
caspase-6 9.9
caspase-2 9.9
caspase-6 9.9
caspase-2 9.8
caspase-7 9.5
caspase-7 9.5
caspase-4 9.2
caspase-4 9.1
acylcarnitine hydrolase 8.8
caspase-3 8.7
caspase-11 8.6
caspase-5 8.5
caspase-11 8.5
caspase-5 8.5
lombricine kinase 7.9
Omi/HtrA2 7.9
PARP 7.7
caspase-1 7.5
AO1 7.0
adamalysin 6.9
DIPP 6.2
10-formyltetrahydrofolate dehydrogenase 6.1
TdT 6.1
3-hydroxy-3-methylglutaryl-CoA lyase 5.9
sphingomyelin synthase 5.9
lysyl-tRNA synthetase 5.7
granzyme B 5.7
neutral sphingomyelinase 5.6
AFR 5.6
aspartase 5.5
ceramidase 5.4
mu-calpain 5.3
m-calpain 5.3
IKK 5.3
ECH 5.3
cathepsin B 5.1
cdc2 5.0
sphingosine kinase 5.0
p100 5.0
mitogen-activated protein kinase 4.9
pseudouridine synthase 4.9
kynurenine aminotransferase 4.8
CYP46A1 4.7
GD3 synthase 4.6
kynurenine 3-monooxygenase 4.6
legumain 4.6
cathepsin C 4.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.5
HCS 4.5
MMP 4.5
glutaryl-CoA dehydrogenase 4.4
phosphatidylinositol 3-kinase 4.3
proteasome 4.3
coproporphyrinogen oxidase 4.2
farnesyltransferase 4.2
MEK 4.1
protein phosphatase 2A 4.1
cathepsin D 4.1
phosphoinositide 3-kinase 4.1
GSK 4.0
TSP-1 4.0
S-adenosylmethionine decarboxylase 4.0
farnesyltransferase 4.0
IMP dehydrogenase 3.9
inositol phosphatase 3.8
nucleotidase 3.8
DNA ligase 3.8
DNA ligase 3.8
ribonucleotide reductase 3.7
TOR 3.7
MEKK1 3.7
PDK1 3.6
MPP 3.6
ribonucleotide reductase 3.6
SNO 3.6
TACE 3.5
more...
Compound
estra-1,3,5(10)-trien-17-ol 12.2
4-chloro-N-methylbenzamide 11.2
Justicidin A 10.9
C14H21N3O2 10.6
C14H21N3O2 10.6
24-Hydroxycholesterol 10.6
C14H21N3O2 10.6
C14H21N3O2 10.6
Cephalochromin 10.6
C14H21N3O2 10.6
Glucoraphenin 10.6
Dihydrosanguinarine 10.2
Sarcophine 10.2
C14H21N3O2 10.2
Cephalostatin 1 10.0
Tigogenin 9.9
2-hexadecanol 9.9
C14H21N3O2 9.9
Saucernetin 9.9
C14H21N3O2 9.9
2,5-Dihydroxyacetophenone 9.6
Gartanin 9.6
alpha-Santalol 9.6
C14H21N3O2 9.6
Raddeanin A 9.5
Deltonin 9.4
methyl 2-benzoylbenzoate 9.4
Linoelaidic acid 9.4
Lupulone 9.4
androst-2-en-17-one 9.2
C14H21N3O2 9.2
Codeinone 9.2
Sinularin 9.2
Rocaglamide 9.1
Didodecyldimethylammonium bromide 9.0
hydroxymethylphosphonic acid 9.0
PHPS 9.0
Tectochrysin 8.9
Bufotalin 8.9
2,4-dimethylpyridine 8.9
N-hydroxybutanamide 8.9
Dihydrochalcone 8.9
Nomilin 8.9
2-hydroxy-1-propanesulfonic acid 8.7
cis-Jasmone 8.7
Chelidonine 8.7
7-Ketocholesterol 8.7
Dicentrine 8.6
N-hydroxybutanamide 8.6
3,4-dimethylpyridine 8.6
Bullatacin 8.5
taurolithocholate 3-sulfate 8.5
Tricetin 8.5
Ginkgetin 8.4
Piperlonguminine 8.4
Methadone hydrochloride 8.4
Morphinone 8.4
Ovatodiolide 8.3
2-oxopropanamide 8.3
Harmol 8.3
Phytosphingosine 8.2
Decursin 8.0
Ver A 8.0
Isofraxidin 7.9
N-hydroxybenzamide 7.9
Decursinol 7.9
2-phenylnaphthalene 7.8
Borrelidin 7.8
Borrelidin 7.7
Phenethyl isothiocyanate 7.7
Bongkrekic acid 7.6
Sulfuretin 7.5
Sanguinarine 7.4
Liriodenine 7.4
Solamargine 7.4
2-Methoxyestradiol 7.4
Scutellarein 7.4
LLY 7.4
Cadinene 7.4
Embelin 7.4
more...