Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:3.4.22.61 (caspase-8)
6,833 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein caspase-8 6750 caspase-3 3145 caspase-9 1986 Bcl-2 1477 Fas 1456 cytochrome c 1210 Bid 785 tumor necrosis factor 645 p53 631 Mol 602 PARP 571 FADD 528 Sep 487 TNF 421 TRAIL 394 CD95 385 FLICE 373 FasL 333 Fas ligand 325 cytokine 289 annexin V 286 p38 285 c-FLIP 266 DR5 259 FLIP 256 JNK 248 poly(ADP-ribose) polymerase 244 endoplasmic reticulum 202 p21 191 XIAP 181 Bak 178 Tumor necrosis factor 169 DR4 161 MAPK 156 RIPK1 155 TNF-alpha 154 ERK 150 ROS 149 cytochrome 147 Smac 145 TNF receptor 144 TNF-related apoptosis-inducing ligand 138 inhibitor of apoptosis 135 poly (ADP-ribose) polymerase 130 GSH 127 Mcl-1 123 proteasome 123 CD95L 117 survivin 112 c-Jun 111 BID 110 TRAIL-R1 107 Apaf-1 105 p65 105 PI3K 103 AKT 99 RIPK3 97 catalase 97 ERK1 96 APO-1 96 TRAIL-R2 94 Bcl-X 92 interacting protein 90 ATP 90 DIABLO 89 RIP1 88 TNFR1 86 anti-apoptotic protein 86 extracellular signal-regulated kinase 86 lipopolysaccharide 85 death receptor 5 84 ubiquitin 84 cyclin D1 82 cIAP2 82 apoptosis-inducing factor 81 superoxide dismutase 81 proteasome inhibitor 80 FAS 78 Fas-associated death domain protein 78 adaptor protein 78 more...

Disease cancer 1812 tumor 1077 leukemia 346 breast cancer 298 hepatocellular carcinoma 224 MCF 203 tumor growth 201 carcinoma 201 colon cancer 152 prostate cancer 152 lung cancer 137 GSH 127 melanoma 124 ischemia 122 neuroblastoma 121 adenocarcinoma 117 lymphoma 116 multiple myeloma 103 glioma 100 colorectal cancer 95 carcinogenesis 92 B-cell lymphoma 91 tumorigenesis 80 FAS 78 acute myeloid leukemia 70 glioblastoma 69 squamous cell carcinoma 69 gastric cancer 67 osteosarcoma 65 ovarian cancer 63 cervical cancer 62 liver cancer 61 Alzheimer's disease 61 acute promyelocytic leukemia 60 non-small cell lung cancer 60 diabetes 58 tumor progression 55 pancreatic cancer 46 virus infection 45 liver cancer 43 lung carcinoma 41 Blocking 38 HIV 37 sepsis 37 epithelial ovarian cancer 36 sepsis 35 stroke 33 Leukemia 32 Parkinson's disease 32 acute lymphoblastic leukemia 32 skin cancer 32 renal cell carcinoma 32 infectious diseases 31 metastases 31 CEM 30 herpes simplex 29 bladder cancer 29 atherosclerosis 29 immunodeficiency 29 chronic myeloid leukemia 28 heart failure 28 myeloid leukemia 25 AGS 24 brain tumor 24 glioblastoma multiforme 24 bacterial infection 24 retinoblastoma 24 oral cancer 23 chronic lymphocytic leukemia 22 Tumour necrosis 22 Infection 21 cerebral ischemia 20 ATM 20 inflammatory bowel disease 20 DDP 20 Yersinia 20 Burkitt's lymphoma 20 colitis 20 solid tumor 20 SCID 19 more...

Symptom collapse 43 starvation 17 seizures 14 hypothermia 11 splenomegaly 9 functional recovery 8 diarrhea 8 hyperoxia 7 pain 6 anesthesia 5 exhaustion 4 headache 3 skin damage 3 weakness 3 dry eye 3 memory loss 3 cachexia 3 insomnia 3 thinning 3 respiratory distress 3 menopausal symptoms 2 tremor 2 sore throat 2 overweight 2 abdominal pain 2 nausea and vomiting 1 nausea 1 ataxia 1 loss of balance 1 hot flashes 1 discomfort 1 acidity 1 HSA 1 acute stress 1 dizziness 1 back pain 1 ataxic gait 1 sleepiness 1 dyspnea 1 alexithymia 1 erythema 1 dystonia 1 low back pain 1 syncope 1 flushing 1 hyperemesis 1 myalgia 1 bradypnea 1 halitosis 1 discomfort 1 tinnitus 1 Tenderness 1

Drug ROS 149 IL-2 41 IFN-gamma 39 Bortezomib 29 Dermatol 25 p75 23 vitamin E 21 lysine 20 ascorbate 17 Taxol 16 Monit 15 IFN-beta 13 Cardiovasc 11 CED 11 Arsenic trioxide 10 ADR 10 CSF 10 MAP 9 caffeine 9 Ethanol 9 Mutagen 8 Glycyrrhiza 8 Flavopiridol 8 Etoposide 7 Sorafenib 7 MRC 7 G-CSF 6 -deoxyadenosine 6 2-Methoxyestradiol 6 Propofol 6 CTX 6 CCL 5 Vitamin E 5 lactose 4 CPT-11 4 Ginseng 4 NVP 4 EE2 4 AMC 4 Emodin 4 Epigallocatechin 4 Emodin 4 Indomethacin 4 ICI 4 Glutathione 4 Angiotensin II 4 ALA 4 Trabectedin 3 CTX 3 CoCl2 3 Amiloride 3 Cantor 3 DHT 3 Glucagon 3 Triad 3 CoCl2 3 DHT 3 Docetaxel 3 Vorinostat 3 Triad 3 EPA 3 CTX 3 Vitamin A 3 Radicicol 3 Dasatinib 3 ADM 3 Hyperforin 3 Simvastatin 3 Vitamin B 3 TAT 3 Growth hormone 2 PTC 2 Isoniazid 2 Bosentan 2 NADH 2 Artesunate 2 Parkin 2 Swainsonine 2 Dial 2 Thioridazine 2 more...

Enzyme caspase-8 6833 caspase-3 3091 caspase-9 1965 PARP 625 mitogen-activated protein kinase 613 caspase-1 245 ERK 223 protein kinase 164 caspase-2 156 caspase-2 155 caspase-7 142 caspase-7 138 proteasome 123 superoxide dismutase 115 catalase 114 caspase-10 114 caspase-10 110 caspase-6 99 caspase-6 96 protein kinase C 80 focal adhesion kinase 71 MEK 68 lactate dehydrogenase 58 luciferase 58 cdc2 56 phosphatidylinositol 3-kinase 48 caspase-4 48 caspase-4 47 IKK 42 glutathione peroxidase 36 granzyme B 36 calcineurin 35 alanine aminotransferase 34 cathepsin B 30 caspase-11 28 aspartate aminotransferase 28 caspase-11 28 TdT 27 ATPase 27 RNase 26 RNase 26 glutathione S-transferase 26 P-glycoprotein 25 GSK 24 peroxidase 23 topoisomerase 21 phosphoinositide 3-kinase 21 AMP-activated protein kinase 21 topoisomerase 21 MMP 20 NADPH oxidase 19 reverse transcriptase 19 glutathione reductase 18 NADPH oxidase 18 succinate dehydrogenase 18 NO synthase 17 Omi/HtrA2 17 complex I 16 cathepsin D 15 alkaline phosphatase 15 NOS 12 phospholipase C 12 trypsin 12 AMPK 11 protein phosphatase 2A 11 collagenase 10 AMPK 10 RNA polymerase 10 tyrosine hydroxylase 10 ECH 9 ribonuclease 9 CAD 9 ribonuclease 9 CAD 9 CAD 9 ribonucleotide reductase 8 creatine kinase 8 ribonucleotide reductase 8 DNase 8 DNA ligase 8 more...

Compound DNA 1148 oxygen 674 Dec 527 TNF 421 MTT 288 cysteine 249 Asp 177 MDA 157 dUTP 142 GSH 130 GSH 130 calcium 127 iodine 124 alanine 113 ADP-ribose 107 Clin 102 ATP 90 nitric oxide 90 N-acetylcysteine 88 glucose 87 boron 82 bromide 78 serine 77 water 75 threonine 67 sodium 66 tyrosine 59 hydrogen 59 ADP 54 ADP 52 ADP 51 ethanol 49 acetate 47 Ile 43 THP 41 MEK 41 THP 41 Curcumin 41 leucine 39 DDP 38 Cytochrome c 37 acridine 36 H2O2 36 ADR 36 ASC 34 Cyt 30 NH2 30 ethyl acetate 30 zinc 29 Adriamycin 29 retinoic acid 28 phosphate 28 Hoechst 33342 28 glutamate 27 arginine 27 Panam 26 sulfate 24 aldehyde 24 His 23 lysine 23 aldehyde 22 nitrogen 22 cadmium 22 galactose 20 5-FU 19 selenium 18 aspartic acid 18 Pac 18 cAMP 18 hexane 18 urea 17 CAT 17 diacetate 17 aspartic acid 17 aspartic acid 17 CAT 17 CAT 17 aspartic acid 17 glutamine 17 copper 16 more...

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