Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.61 (caspase-8)
 6,833 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
NADH-ubiquinone oxidoreductase B18 subunit 12.2
EFR3 homolog B 12.2
caspase and RIP adapter with death domain 12.2
Death associated protein 3 12.2
caspase-8 11.8
Apoptotic peptidase activating factor 1 11.2
sorting nexin 7 11.2
C4orf22 11.2
Sal-like 4 (Drosophila) 11.2
G1/S-specific cyclin E2 11.2
FLICE 11.0
Fas-associated death domain protein 10.9
FADD 10.9
DEDD2 10.9
c-FLIP 10.7
Bid 10.6
FLICE-associated huge protein 10.6
EPH receptor B4 10.6
inhibitor of growth family, member 3 10.6
DOPEY1 10.6
PTPRK protein 10.6
TNFR1-associated death domain protein 10.3
FLIP 10.3
PMEPA1 protein 10.2
receptor (TNFRSF)-interacting serine-threonine kinase 1 10.2
EFR3B 10.2
NUDT10 10.2
pFIV 10.2
uveal autoantigen with coiled-coil domains and ankyrin repeats 10.2
Squamous cell carcinoma antigen 1 10.2
BAP29 10.2
CASP-9 10.0
death effector domain-containing 10.0
FAS-associated death domain protein 9.9
caspase-9 9.9
ING3 protein 9.9
apolipoprotein L6 9.9
rosbin 9.9
hRFI 9.9
claudin 12 9.9
more...
Disease
LACH 10.6
HMN7B 10.2
Acute glaucoma 9.5
DFNB59 8.3
methionine synthase deficiency 8.2
autoimmune lymphoproliferative syndrome 8.0
AIDS cholangiopathy 7.8
Reovirus infection 7.7
Corneal infection 7.3
amok 7.1
AD5 7.0
KRS 7.0
salivary gland adenoid cystic carcinoma 6.9
salivary gland cancer 6.9
childhood rhabdomyosarcoma 6.6
mouse leukemia P388 6.6
VED 6.5
FAS 6.5
CYLD 6.4
salivary gland adenocarcinoma 6.4
Testicular Cancer 6.3
colon neoplasm 6.3
Cytokine storm 6.3
DFNA5 6.2
Epithelioma 6.1
Chronic beryllium disease 6.1
cowpox 6.0
Canine distemper 5.8
VES 5.8
molluscum contagiosum 5.8
Metastatic colorectal cancer 5.8
Aspergillus fumigatus infection 5.7
Tumour necrosis 5.7
Epidermolysis bullosa simplex 5.7
Mucolipidosis type IV 5.7
AGS 5.6
carbuncle 5.5
X-linked lymphoproliferative syndrome 5.5
retinal vascular occlusion 5.4
pediatric solid tumor 5.3
more...
Symptom
bradypnea 4.5
hyperemesis 4.0
Tenderness 3.6
loss of balance 3.4
skin damage 3.2
ataxic gait 3.1
halitosis 3.0
collapse 2.8
hyperoxia 2.6
menopausal symptoms 2.5
dry eye 2.4
hot flashes 2.1
splenomegaly 2.1
memory loss 2.0
sore throat 1.8
starvation 1.7
hypothermia 1.6
functional recovery 1.5
alexithymia 1.4
cachexia 1.3
HSA 0.6
exhaustion 0.4
insomnia 0.4
thinning 0.3
acute stress 0.0
seizures -0.3
flushing -0.5
respiratory distress -0.5
myalgia -0.5
tinnitus -0.5
diarrhea -0.6
dystonia -0.9
tremor -1.0
syncope -1.0
nausea and vomiting -1.0
dizziness -1.1
low back pain -1.1
back pain -1.4
weakness -1.4
sleepiness -1.5
more...
Drug
Edratide 12.2
2-Iminobiotin 9.6
Lexatumumab 9.6
Alexidine 9.2
Zedoary 8.9
Mapatumumab 8.9
Methadone hydrochloride 8.7
3,4-Dichloroisocoumarin 8.7
Bear bile 8.7
Cupric sulfate 8.2
Citrus unshiu peel 8.1
Naftopidil 7.9
Mevastatin 7.8
Radicicol 7.7
Avasimibe 7.6
Flavopiridol 7.5
Motexafin gadolinium 7.5
Sodium ascorbate 7.4
Berberine chloride 7.4
2-Methoxyestradiol 7.4
Irofulven 7.2
Lonafarnib 7.0
Ilomastat 6.9
Bucillamine 6.9
Olomoucine 6.7
Peridinin 6.7
Hyperforin 6.7
Trabectedin 6.6
Bortezomib 6.5
CED 6.5
CA-074 6.4
Nafamostat mesilate 6.2
Dextran sulfate sodium 6.1
Revlimid 6.1
Zebularine 6.1
Swainsonine 5.8
Rasburicase 5.7
Batimastat 5.7
Batimastat 5.7
Mizoribine 5.6
more...
Enzyme
caspase-8 12.2
caspase-10 11.5
caspase-10 11.5
caspase-9 10.3
caspase-6 9.9
caspase-2 9.9
caspase-6 9.9
caspase-2 9.8
caspase-7 9.5
caspase-7 9.5
caspase-4 9.2
caspase-4 9.1
acylcarnitine hydrolase 8.8
caspase-3 8.7
caspase-11 8.6
caspase-5 8.5
caspase-11 8.5
caspase-5 8.5
lombricine kinase 7.9
Omi/HtrA2 7.9
PARP 7.7
caspase-1 7.5
AO1 7.0
adamalysin 6.9
DIPP 6.2
10-formyltetrahydrofolate dehydrogenase 6.1
TdT 6.1
3-hydroxy-3-methylglutaryl-CoA lyase 5.9
sphingomyelin synthase 5.9
lysyl-tRNA synthetase 5.7
granzyme B 5.7
neutral sphingomyelinase 5.6
AFR 5.6
aspartase 5.5
ceramidase 5.4
mu-calpain 5.3
m-calpain 5.3
IKK 5.3
ECH 5.3
cathepsin B 5.1
more...
Compound
estra-1,3,5(10)-trien-17-ol 12.2
4-chloro-N-methylbenzamide 11.2
Justicidin A 10.9
C14H21N3O2 10.6
C14H21N3O2 10.6
Cephalochromin 10.6
Glucoraphenin 10.6
C14H21N3O2 10.6
C14H21N3O2 10.6
C14H21N3O2 10.6
24-Hydroxycholesterol 10.6
Sarcophine 10.2
C14H21N3O2 10.2
Dihydrosanguinarine 10.2
Cephalostatin 1 10.0
Saucernetin 9.9
C14H21N3O2 9.9
2-hexadecanol 9.9
Tigogenin 9.9
C14H21N3O2 9.9
2,5-Dihydroxyacetophenone 9.6
alpha-Santalol 9.6
C14H21N3O2 9.6
Gartanin 9.6
Raddeanin A 9.5
Lupulone 9.4
methyl 2-benzoylbenzoate 9.4
Deltonin 9.4
Linoelaidic acid 9.4
Sinularin 9.2
Codeinone 9.2
androst-2-en-17-one 9.2
C14H21N3O2 9.2
Rocaglamide 9.1
Didodecyldimethylammonium bromide 9.0
hydroxymethylphosphonic acid 9.0
PHPS 9.0
Bufotalin 8.9
Dihydrochalcone 8.9
2,4-dimethylpyridine 8.9
more...