Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.61 (caspase-8)
 6,833 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase and RIP adapter with death domain 12.2
Death associated protein 3 12.2
NADH-ubiquinone oxidoreductase B18 subunit 12.2
EFR3 homolog B 12.2
caspase-8 11.8
C4orf22 11.2
G1/S-specific cyclin E2 11.2
Sal-like 4 (Drosophila) 11.2
Apoptotic peptidase activating factor 1 11.2
sorting nexin 7 11.2
FLICE 11.0
Fas-associated death domain protein 10.9
FADD 10.9
DEDD2 10.9
c-FLIP 10.7
Bid 10.6
FLICE-associated huge protein 10.6
inhibitor of growth family, member 3 10.6
EPH receptor B4 10.6
PTPRK protein 10.6
DOPEY1 10.6
TNFR1-associated death domain protein 10.3
FLIP 10.3
EFR3B 10.2
Squamous cell carcinoma antigen 1 10.2
NUDT10 10.2
BAP29 10.2
receptor (TNFRSF)-interacting serine-threonine kinase 1 10.2
PMEPA1 protein 10.2
uveal autoantigen with coiled-coil domains and ankyrin repeats 10.2
pFIV 10.2
CASP-9 10.0
death effector domain-containing 10.0
FAS-associated death domain protein 9.9
caspase-9 9.9
TNFRSF1A-associated via death domain 9.9
GAGE-7 9.9
CARD12 9.9
rosbin 9.9
ING3 protein 9.9
claudin 12 9.9
apolipoprotein L6 9.9
hRFI 9.9
DFF35 9.9
SH3RF2 9.9
claudin-12 9.8
death receptor 5 9.8
ICH-2 9.7
HIPPI 9.7
caspase 10 9.7
BH3 interacting domain death agonist 9.7
TRAIL-R2 9.7
FADD protein 9.7
RIPK3 9.6
fucosyltransferase 3 9.6
G protein-coupled receptor 124 9.6
cds2 9.6
TMEM219 9.6
SERP2 9.6
RGPR-p117 9.6
TRADD 9.5
CRADD 9.5
TNF-related apoptosis-inducing ligand 9.4
RIPK1 9.4
longevity assurance gene 1 9.4
RAIDD 9.4
APBB1IP 9.4
CA-XIV 9.4
LASS5 9.4
RIP-1 9.3
DcR1 9.3
Smac 9.3
TNF receptor-associated protein 9.3
RIP1 9.3
TRAIL-R1 9.3
p12 subunit 9.2
NHLRC2 9.2
ICEBERG 9.2
PYPAF7 9.2
myc proto-oncogene protein 9.2
HECTD3 9.2
102kD 9.2
DAP3 9.1
Z-DNA binding protein 1 9.1
DcR2 9.1
TRAIL 9.1
cIAP1 9.1
MLKL 9.1
RIP3 9.1
ASB3 9.0
c-myc binding protein 9.0
PUS7 9.0
zinc finger protein 91 9.0
FasL 9.0
Fas 9.0
DR5 9.0
ICAD 9.0
CD95 8.9
CFLAR 8.9
TOSO 8.9
2-hydroxyphytanoyl-CoA lyase 8.9
PAPK 8.9
CYP24A1 protein 8.9
ACVR1C 8.9
claudin 15 8.9
cytochrome c, somatic 8.9
SNX7 8.9
ribosomal protein L39 8.9
FAS ligand 8.9
Apaf-1 8.8
endonuclease G 8.8
CD95L 8.8
GSDMC 8.7
Inhibitory PAS domain protein 8.7
RNF183 8.7
pyrin domain containing 1 8.7
Gal-T2 8.7
DIABLO 8.7
Che-1 8.7
PSTPIP2 8.7
PEA-15 8.7
caspase 2 8.7
RIP-3 8.6
XIAP 8.6
AIF 8.6
DEDD 8.6
gasdermin 8.6
HOIL-1 8.6
FBXO45 8.6
PNAS-4 8.6
ZBP1 8.6
apoptosis-inducing factor) 8.6
TNF-related apoptosis-inducing ligand receptor 2 8.5
caspase-14 8.5
death receptor 6 8.5
Hyal-3 8.5
Factor associated with neutral sphingomyelinase activation 8.5
claudin-15 8.5
FAIM 8.5
monocarboxylate transporter isoform 1 8.5
Ret finger protein 8.5
CAP2 8.5
cIAP2 8.5
Fas ligand 8.5
prostate apoptosis response-4 8.5
APO1 8.4
TRIM13 8.4
CARP-1 8.4
RAPGEF2 8.4
AIM2 protein 8.4
casp 8.4
PCTAIRE1 8.4
XIAP-associated factor 1 8.4
PRKR-like endoplasmic reticulum kinase 8.4
APO-1 8.4
CYCS 8.4
caspase-3 8.3
BID 8.3
X-linked inhibitor of apoptosis protein 8.3
Bak 8.3
more...
Disease
LACH 10.6
HMN7B 10.2
Acute glaucoma 9.5
DFNB59 8.3
methionine synthase deficiency 8.2
autoimmune lymphoproliferative syndrome 8.0
AIDS cholangiopathy 7.8
Reovirus infection 7.7
Corneal infection 7.3
amok 7.1
KRS 7.0
AD5 7.0
salivary gland adenoid cystic carcinoma 6.9
salivary gland cancer 6.9
mouse leukemia P388 6.6
childhood rhabdomyosarcoma 6.6
VED 6.5
FAS 6.5
CYLD 6.4
salivary gland adenocarcinoma 6.4
colon neoplasm 6.3
Testicular Cancer 6.3
Cytokine storm 6.3
DFNA5 6.2
Epithelioma 6.1
Chronic beryllium disease 6.1
cowpox 6.0
Canine distemper 5.8
VES 5.8
molluscum contagiosum 5.8
Metastatic colorectal cancer 5.8
Aspergillus fumigatus infection 5.7
Tumour necrosis 5.7
Epidermolysis bullosa simplex 5.7
Mucolipidosis type IV 5.7
AGS 5.6
carbuncle 5.5
X-linked lymphoproliferative syndrome 5.5
retinal vascular occlusion 5.4
pediatric solid tumor 5.3
DRD 5.3
Oral infection 5.3
Neuroblastoma 5.2
Neuroblastoma 5.2
Barth syndrome 5.2
adrenal cancer 5.2
closed angle glaucoma 5.2
acute promyelocytic leukemia 5.2
ED3 5.2
Inverted papilloma 5.1
Askin tumor 5.1
Vesicular stomatitis 5.1
MCF 5.1
Photosensitization 5.1
CEM 5.1
cancer regression 5.0
LGL leukemia 5.0
RP3 5.0
Ileum 5.0
testicular dysfunction 5.0
Retinal ischemia 5.0
cervical adenocarcinoma 4.9
Glioblastoma 4.9
myeloid leukemia 4.9
Aeromonas hydrophila infection 4.9
Candida albicans infection 4.8
CM1 4.8
FGG 4.8
Keshan disease 4.8
mast cell leukemia 4.8
HEP 4.7
Acute liver failure 4.7
MTS 4.7
B-cell lymphoma 4.7
adrenocortical cancer 4.7
HOS 4.6
lymphomatoid granulomatosis 4.6
Mouse hepatitis 4.6
monocytic leukemia 4.6
colon cancer 4.6
Chemoradiation 4.6
anaplastic thyroid cancer 4.5
Osteosarcoma 4.5
Osteosarcoma 4.5
herpes labialis 4.5
Insulinoma 4.5
ileocolitis 4.5
Neonatal sepsis 4.5
myocardial hypoxia 4.5
Gallbladder carcinoma 4.5
ASM 4.5
immunotoxicity 4.4
Kashin-Beck disease 4.4
histiocytic lymphoma 4.4
Malignant glioma 4.4
TNS 4.4
Invasive pulmonary aspergillosis 4.4
Angiostrongylus cantonensis 4.4
bone neoplasm 4.4
vitamin B6 deficiency 4.3
neuroblastoma 4.3
uterine sarcoma 4.3
diabetic hyperglycemia 4.3
Pseudomonas infection 4.3
Colon cancer 4.3
Simpson-Golabi-Behmel syndrome 4.3
Shigella boydii 4.3
Primary effusion lymphoma 4.3
malignant meningioma 4.3
Blocking 4.3
oral cancer 4.3
HCC 4.2
liver cancer 4.2
Bowen's disease 4.2
Medulloblastoma 4.2
CCL 4.2
osteosarcoma 4.2
Autosomal recessive polycystic kidney disease 4.2
bone cancer 4.2
multicentric Castleman's disease 4.2
hemangiosarcoma 4.2
immune disorder 4.1
PARK7 4.1
glioblastoma 4.1
liver cancer 4.1
DDP 4.1
refractory cancer 4.1
leukemia 4.1
Choriocarcinoma 4.1
metastatic neuroblastoma 4.1
malignant mesothelioma 4.1
renal ischemia 4.1
megakaryocytic leukemia 4.0
adult T-cell leukemia/lymphoma 4.0
tumor growth 4.0
RARS 4.0
Wright 4.0
GSH 4.0
toxic nodular goiter 3.9
EGC 3.9
beryllium disease 3.9
Ureteral obstruction 3.9
Burkitt's lymphoma 3.9
Vascular lesions 3.9
BEN 3.9
glioma 3.9
blood cancer 3.9
T-cell acute lymphoblastic leukemia 3.9
hormone refractory prostate cancer 3.9
ARC 3.9
hypertensive retinopathy 3.9
hepatocellular carcinoma 3.9
Rhabdomyosarcoma 3.9
epithelial ovarian cancer 3.9
Immune thrombocytopenia 3.8
metastatic neuroblastoma 3.8
PBD 3.8
OPA1 3.8
pneumonic plague 3.8
leukoderma 3.8
more...
Symptom
bradypnea 4.5
hyperemesis 4.0
Tenderness 3.6
loss of balance 3.4
skin damage 3.2
ataxic gait 3.1
halitosis 3.0
collapse 2.8
hyperoxia 2.6
menopausal symptoms 2.5
dry eye 2.4
hot flashes 2.1
splenomegaly 2.1
memory loss 2.0
sore throat 1.8
starvation 1.7
hypothermia 1.6
functional recovery 1.5
alexithymia 1.4
cachexia 1.3
HSA 0.6
exhaustion 0.4
insomnia 0.4
thinning 0.3
acute stress 0.0
seizures -0.3
flushing -0.5
respiratory distress -0.5
myalgia -0.5
tinnitus -0.5
diarrhea -0.6
dystonia -0.9
tremor -1.0
syncope -1.0
nausea and vomiting -1.0
dizziness -1.1
low back pain -1.1
back pain -1.4
weakness -1.4
sleepiness -1.5
erythema -1.5
overweight -1.5
acidity -1.7
abdominal pain -1.7
ataxia -1.8
headache -2.0
anesthesia -2.2
discomfort -2.3
nausea -2.3
discomfort -2.4
dyspnea -2.6
pain -3.2
Drug
Edratide 12.2
2-Iminobiotin 9.6
Lexatumumab 9.6
Alexidine 9.2
Mapatumumab 8.9
Zedoary 8.9
Methadone hydrochloride 8.7
3,4-Dichloroisocoumarin 8.7
Bear bile 8.7
Cupric sulfate 8.2
Citrus unshiu peel 8.1
Naftopidil 7.9
Mevastatin 7.8
Radicicol 7.7
Avasimibe 7.6
Flavopiridol 7.5
Motexafin gadolinium 7.5
Berberine chloride 7.4
Sodium ascorbate 7.4
2-Methoxyestradiol 7.4
Irofulven 7.2
Lonafarnib 7.0
Ilomastat 6.9
Bucillamine 6.9
Olomoucine 6.7
Peridinin 6.7
Hyperforin 6.7
Trabectedin 6.6
Bortezomib 6.5
CED 6.5
CA-074 6.4
Nafamostat mesilate 6.2
Dextran sulfate sodium 6.1
Zebularine 6.1
Revlimid 6.1
Swainsonine 5.8
Rasburicase 5.7
Batimastat 5.7
Batimastat 5.7
Mizoribine 5.6
Onconase 5.4
Epigallocatechin 5.4
Compound 18 5.4
Vorinostat 5.3
Emodin 5.3
Thioridazine 5.3
Etodolac 5.2
Arsenic trioxide 5.2
Cantor 5.2
Propidium 5.2
ROS 5.2
RBT 5.0
ID2 5.0
Emodin 5.0
Etoposide 4.8
p75 4.8
Artesunate 4.8
Bromelain 4.7
Glycyrrhiza 4.7
Casodex 4.6
Cetrorelix 4.6
Taxol 4.5
Dasatinib 4.5
BLyS 4.5
Tranilast 4.5
ADR 4.5
Triad 4.5
Olmesartan 4.5
Bosentan 4.5
Bosentan 4.5
Rolipram 4.4
Sorafenib 4.4
Poloxamer 188 4.4
Calcium chloride 4.4
Triad 4.4
Spiegel 4.3
IFN-beta 4.3
Pirfenidone 4.3
NVP 4.3
PFT 4.3
Rasburicase 4.2
Voltaren 4.2
CCL 4.2
Geranium 4.1
Areca 4.1
AMC 4.0
Perindopril 3.8
Colistin 3.8
-deoxyadenosine 3.8
Propofol 3.7
HPMPC 3.7
Limonene 3.7
TRM 3.7
Tao 3.6
Orlistat 3.6
Doyle 3.5
Rosiglitazone 3.5
Pravastatin 3.5
Ginseng 3.5
MDM 3.5
CoCl2 3.5
CoCl2 3.5
Vitamin B 3.5
Vinorelbine 3.5
Diclofenac sodium 3.4
Trifluoperazine 3.4
Oxaliplatin 3.3
OMP 3.3
CPT-11 3.3
Isoniazid 3.3
MRC 3.3
Hyaluronidase 3.2
Citric acid 3.2
Dihydro 3.2
Adalimumab 3.1
Troglitazone 3.1
Simvastatin 3.1
Salicylate 3.1
Docetaxel 3.0
Amiloride 3.0
Urokinase 2.9
Budesonide 2.9
VCR 2.9
Kainic acid 2.8
Lenalidomide 2.8
Rutin 2.8
Vitamin E 2.8
Lovastatin 2.8
Phosphatidylserine 2.8
Everolimus 2.7
Vitamin K 2.7
ALA 2.7
IL-2 2.7
Raloxifene 2.7
DHT 2.7
IFN-gamma 2.7
Mutagen 2.6
Erlotinib 2.6
DHT 2.6
Triclosan 2.6
Zoledronic acid 2.5
TAT 2.5
Ofloxacin 2.5
Xanthium 2.5
vitamin E 2.5
PTC 2.4
G-CSF 2.4
DBS 2.4
Adenosine triphosphate 2.4
Photofrin 2.3
DFP 2.3
Parkin 2.3
TTC 2.3
Parkin 2.3
Monensin 2.3
TAK 2.2
Vitamin A 2.2
Omeprazole 2.2
ADM 2.2
AraC 2.1
more...
Enzyme
caspase-8 12.2
caspase-10 11.5
caspase-10 11.5
caspase-9 10.3
caspase-6 9.9
caspase-2 9.9
caspase-6 9.9
caspase-2 9.8
caspase-7 9.5
caspase-7 9.5
caspase-4 9.2
caspase-4 9.1
acylcarnitine hydrolase 8.8
caspase-3 8.7
caspase-11 8.6
caspase-5 8.5
caspase-11 8.5
caspase-5 8.5
lombricine kinase 7.9
Omi/HtrA2 7.9
PARP 7.7
caspase-1 7.5
AO1 7.0
adamalysin 6.9
DIPP 6.2
10-formyltetrahydrofolate dehydrogenase 6.1
TdT 6.1
3-hydroxy-3-methylglutaryl-CoA lyase 5.9
sphingomyelin synthase 5.9
lysyl-tRNA synthetase 5.7
granzyme B 5.7
neutral sphingomyelinase 5.6
AFR 5.6
aspartase 5.5
ceramidase 5.4
mu-calpain 5.3
m-calpain 5.3
IKK 5.3
ECH 5.3
cathepsin B 5.1
cdc2 5.0
sphingosine kinase 5.0
p100 5.0
mitogen-activated protein kinase 4.9
pseudouridine synthase 4.9
kynurenine aminotransferase 4.8
CYP46A1 4.7
GD3 synthase 4.6
kynurenine 3-monooxygenase 4.6
legumain 4.6
cathepsin C 4.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.5
HCS 4.5
MMP 4.5
glutaryl-CoA dehydrogenase 4.4
phosphatidylinositol 3-kinase 4.3
proteasome 4.3
coproporphyrinogen oxidase 4.2
farnesyltransferase 4.2
MEK 4.1
protein phosphatase 2A 4.1
cathepsin D 4.1
phosphoinositide 3-kinase 4.1
GSK 4.0
TSP-1 4.0
S-adenosylmethionine decarboxylase 4.0
farnesyltransferase 4.0
IMP dehydrogenase 3.9
inositol phosphatase 3.8
nucleotidase 3.8
DNA ligase 3.8
DNA ligase 3.8
ribonucleotide reductase 3.7
TOR 3.7
MEKK1 3.7
PDK1 3.6
MPP 3.6
ribonucleotide reductase 3.6
SNO 3.6
TACE 3.5
transaldolase 3.5
galactocerebrosidase 3.5
ERK 3.4
arginine deiminase 3.4
topoisomerase 3.4
KAT 3.4
myosin light chain kinase 3.4
succinate dehydrogenase 3.4
lactic acid dehydrogenase 3.4
adenosine kinase 3.3
topoisomerase 3.3
lactic acid dehydrogenase 3.3
gamma-glutamylcysteine synthetase 3.3
HMG-CoA synthase 3.3
glucosylceramide synthase 3.3
CAD 3.3
catalase 3.3
calcineurin 3.3
CAD 3.2
protein kinase 3.2
cathepsin S 3.2
lactate dehydrogenase 3.2
CAD 3.2
triphosphatase 3.2
superoxide dismutase 3.2
polo-like kinase 1 3.2
apyrase 3.2
TRS 3.2
paraoxonase 3.2
peroxiredoxin 3.1
glutathione reductase 3.1
P-glycoprotein 3.1
CNPase 3.1
p80 3.1
HK2 3.1
complex I 3.1
glycine decarboxylase 3.0
myrosinase 3.0
NADPH oxidase 3.0
CDH 3.0
15-lipoxygenase 3.0
NADPH oxidase 3.0
NOS 2.9
glutathione peroxidase 2.9
protein kinase C 2.9
focal adhesion kinase 2.9
AMP-activated protein kinase 2.9
cysteine synthase 2.9
15-hydroxyprostaglandin dehydrogenase 2.9
RNase 2.9
AMPK 2.9
factor C 2.9
endothelin-converting enzyme 2.9
DCF 2.8
luciferase 2.8
glutathione synthetase 2.8
MMP-3 2.8
cholesterol acyltransferase 2.8
argininosuccinate synthetase 2.8
cholesterol oxidase 2.8
RNase 2.8
deoxycytidine kinase 2.7
PGM 2.7
SOR 2.7
ornithine aminotransferase 2.7
ribonuclease 2.7
ribonuclease 2.7
insulin-degrading enzyme 2.7
CEP 2.6
AST 2.6
sialyltransferase 2.6
lactic acid dehydrogenase 2.6
sialyltransferase 2.6
sialyltransferase 2.6
aspartate aminotransferase 2.6
alanine aminotransferase 2.6
TAT 2.5
ubiquitin-protein ligase 2.5
SPS 2.5
methionine synthase 2.5
more...
Compound
estra-1,3,5(10)-trien-17-ol 12.2
4-chloro-N-methylbenzamide 11.2
Justicidin A 10.9
C14H21N3O2 10.6
24-Hydroxycholesterol 10.6
C14H21N3O2 10.6
Cephalochromin 10.6
Glucoraphenin 10.6
C14H21N3O2 10.6
C14H21N3O2 10.6
C14H21N3O2 10.6
Dihydrosanguinarine 10.2
Sarcophine 10.2
C14H21N3O2 10.2
Cephalostatin 1 10.0
Saucernetin 9.9
C14H21N3O2 9.9
Tigogenin 9.9
C14H21N3O2 9.9
2-hexadecanol 9.9
C14H21N3O2 9.6
Gartanin 9.6
alpha-Santalol 9.6
2,5-Dihydroxyacetophenone 9.6
Raddeanin A 9.5
Deltonin 9.4
Lupulone 9.4
methyl 2-benzoylbenzoate 9.4
Linoelaidic acid 9.4
C14H21N3O2 9.2
Codeinone 9.2
androst-2-en-17-one 9.2
Sinularin 9.2
Rocaglamide 9.1
PHPS 9.0
Didodecyldimethylammonium bromide 9.0
hydroxymethylphosphonic acid 9.0
N-hydroxybutanamide 8.9
Nomilin 8.9
Dihydrochalcone 8.9
Bufotalin 8.9
2,4-dimethylpyridine 8.9
Tectochrysin 8.9
Chelidonine 8.7
2-hydroxy-1-propanesulfonic acid 8.7
cis-Jasmone 8.7
7-Ketocholesterol 8.7
N-hydroxybutanamide 8.6
3,4-dimethylpyridine 8.6
Dicentrine 8.6
Bullatacin 8.5
Tricetin 8.5
taurolithocholate 3-sulfate 8.5
Ginkgetin 8.4
Piperlonguminine 8.4
Morphinone 8.4
Methadone hydrochloride 8.4
Ovatodiolide 8.3
2-oxopropanamide 8.3
Harmol 8.3
Phytosphingosine 8.2
Decursin 8.0
Ver A 8.0
Isofraxidin 7.9
N-hydroxybenzamide 7.9
Decursinol 7.9
Borrelidin 7.8
2-phenylnaphthalene 7.8
Borrelidin 7.7
Phenethyl isothiocyanate 7.7
Bongkrekic acid 7.6
Sulfuretin 7.5
Solamargine 7.4
Liriodenine 7.4
Sanguinarine 7.4
2-Methoxyestradiol 7.4
Cadinene 7.4
LLY 7.4
Scutellarein 7.4
Embelin 7.4
Isoalantolactone 7.3
Berberine chloride 7.3
Celastrol 7.3
Bullatacin 7.3
Morusin 7.3
Imexon 7.2
Gentiopicroside 7.2
3-Deazaadenosine 7.2
Dioscin 7.2
Dioscin 7.2
Acacetin 7.2
Janus Green B 7.2
Guggulsterone 7.2
3,5-dimethylpyridine 7.2
Benzohydroxamic acid 7.2
Neoxanthin 7.2
benzo[c]phenanthridine 7.2
Boswellic acid 7.1
Wedelolactone 7.1
Boldine 7.1
OLN 7.1
1-phenyl-1H-pyrazole 7.1
Chrysophanol 7.0
1,3-benzoxazole 7.0
Geranylgeraniol 7.0
Aloe-emodin 7.0
Chrysophanol 7.0
Geranylgeranylacetone 7.0
Costunolide 7.0
Bisphenol A diglycidyl ether 7.0
Cordycepin 7.0
Cordycepin 7.0
Cordycepin 6.9
Oleandrin 6.9
Humulene 6.9
Cobaltous chloride 6.9
Taurochenodeoxycholate 6.9
Ursolic acid 6.9
Propyl gallate 6.9
Pheophorbide a 6.9
Anisomycin 6.9
Pheophorbide a 6.9
chelidonine 6.8
Pyrogallol 6.8
Oridonin 6.8
Fisetin 6.8
Blue Tetrazolium 6.8
Glycyrrhetinic acid 6.8
Gambogic acid 6.7
Angelicin 6.7
Poly C 6.7
Hyperforin 6.7
beta-Lapachone 6.7
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 6.7
Evodiamine 6.7
Methylguanidine 6.7
Benzyl isothiocyanate 6.7
Noscapine 6.7
Geraniin 6.7
NOXA 6.6
NPIP 6.6
Helenalin 6.6
Epichlorohydrin 6.6
Evodiamine 6.6
Rottlerin 6.6
Esculetin 6.5
Hispidulin 6.5
Tanshinone 6.5
Hyperoside 6.5
celastrol 6.5
Bufalin 6.5
Rottlerin 6.5
Rottlerin 6.5
Diosgenin 6.5
Cytochrome c 6.5
Ginsenoside Re 6.5
Glycyrrhetinic acid 6.5
Nodularin 6.5
Danthron 6.4
dUTP 6.4
more...