Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.61 (caspase-8)
 6,833 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-8 6750
caspase-3 3145
caspase-9 1986
Bcl-2 1477
Fas 1456
cytochrome c 1210
Bid 785
tumor necrosis factor 645
p53 631
Mol 602
PARP 571
FADD 528
Sep 487
TNF 421
TRAIL 394
CD95 385
FLICE 373
FasL 333
Fas ligand 325
cytokine 289
annexin V 286
p38 285
c-FLIP 266
DR5 259
FLIP 256
JNK 248
poly(ADP-ribose) polymerase 244
endoplasmic reticulum 202
p21 191
XIAP 181
Bak 178
Tumor necrosis factor 169
DR4 161
MAPK 156
RIPK1 155
TNF-alpha 154
ERK 150
ROS 149
cytochrome 147
Smac 145
TNF receptor 144
TNF-related apoptosis-inducing ligand 138
inhibitor of apoptosis 135
poly (ADP-ribose) polymerase 130
GSH 127
Mcl-1 123
proteasome 123
CD95L 117
survivin 112
c-Jun 111
BID 110
TRAIL-R1 107
Apaf-1 105
p65 105
PI3K 103
AKT 99
RIPK3 97
catalase 97
ERK1 96
APO-1 96
TRAIL-R2 94
Bcl-X 92
ATP 90
interacting protein 90
DIABLO 89
RIP1 88
extracellular signal-regulated kinase 86
anti-apoptotic protein 86
TNFR1 86
lipopolysaccharide 85
death receptor 5 84
ubiquitin 84
cyclin D1 82
cIAP2 82
apoptosis-inducing factor 81
superoxide dismutase 81
proteasome inhibitor 80
FAS 78
Fas-associated death domain protein 78
adaptor protein 78
bcl-2 77
BAX 75
MLKL 73
tumor necrosis factor receptor 69
IL-6 69
histone deacetylase 69
AIF 68
Bax protein 67
p38 mitogen-activated protein kinase 67
interferon 66
calpain 66
IFN 66
p27 64
PC-3 64
bax 63
pro-apoptotic protein 62
IAP 61
NLRP3 60
inducible nitric oxide synthase 60
osteosarcoma 60
cIAP1 60
tumor necrosis factor alpha 58
PARP-1 58
CD4 58
mTOR 57
LC3 57
RIP3 55
histone 55
X-linked inhibitor of apoptosis protein 55
lactate dehydrogenase 54
lymphoid 54
LPS 54
cyclin B1 54
mitogen-activated protein 51
ADP 51
CHOP 49
TRADD 49
STAT3 48
phosphatidylinositol 3-kinase 48
TLR4 48
TRAF2 48
TNF-R1 48
RIP 48
interleukin-6 45
vascular endothelial growth factor 45
CD8 45
cyclin 44
IL-8 42
tyrosine kinase 42
MEK 42
THP 41
IL-10 41
insulin 41
IL-2 41
p62 41
proliferating cell nuclear antigen 41
colon carcinoma 40
IFN-gamma 40
cyclin E 40
PC3 39
SOD 39
endonuclease G 38
estrogen receptor 37
JNK1 37
catenin 37
Cytochrome c 37
interferon-gamma 37
MMP-9 37
promyelocytic leukemia 37
granzyme B 36
IL-18 35
cyclooxygenase-2 35
CPP32 35
glutathione peroxidase 35
membrane-bound 34
collagen 34
ASC 34
ICAD 33
TdT 32
VEGF 32
more...
Disease
cancer 1812
tumor 1077
leukemia 346
breast cancer 298
hepatocellular carcinoma 224
MCF 203
carcinoma 201
tumor growth 201
prostate cancer 152
colon cancer 152
lung cancer 137
GSH 127
melanoma 124
ischemia 122
neuroblastoma 121
adenocarcinoma 117
lymphoma 116
multiple myeloma 103
glioma 100
colorectal cancer 95
carcinogenesis 92
B-cell lymphoma 91
tumorigenesis 80
FAS 78
acute myeloid leukemia 70
squamous cell carcinoma 69
glioblastoma 69
gastric cancer 67
osteosarcoma 65
ovarian cancer 63
cervical cancer 62
Alzheimer's disease 61
liver cancer 61
non-small cell lung cancer 60
acute promyelocytic leukemia 60
diabetes 58
tumor progression 55
pancreatic cancer 46
virus infection 45
liver cancer 43
lung carcinoma 41
Blocking 38
sepsis 37
HIV 37
epithelial ovarian cancer 36
sepsis 35
stroke 33
skin cancer 32
renal cell carcinoma 32
acute lymphoblastic leukemia 32
Parkinson's disease 32
Leukemia 32
infectious diseases 31
metastases 31
CEM 30
atherosclerosis 29
immunodeficiency 29
bladder cancer 29
herpes simplex 29
chronic myeloid leukemia 28
heart failure 28
myeloid leukemia 25
brain tumor 24
bacterial infection 24
glioblastoma multiforme 24
AGS 24
retinoblastoma 24
oral cancer 23
chronic lymphocytic leukemia 22
Tumour necrosis 22
Infection 21
cerebral ischemia 20
Burkitt's lymphoma 20
Yersinia 20
colitis 20
solid tumor 20
DDP 20
inflammatory bowel disease 20
ATM 20
SCID 19
Huntington's disease 19
Glioblastoma 19
rheumatoid arthritis 19
obesity 19
myocardial ischemia 18
autoimmune disease 18
Neuroblastoma 18
NOD 18
hepatitis 18
Neuroblastoma 18
chronic lymphocytic leukemia 17
suicide 17
cold 17
myocardial infarction 17
influenza 17
multiple sclerosis 16
autoimmune lymphoproliferative syndrome 16
Mycobacterium 16
endometrial cancer 16
cytomegalovirus 16
hypertension 15
Epstein 15
asthma 15
systemic lupus erythematosus 15
MTS 15
type 2 diabetes 14
tuberculosis 14
medulloblastoma 14
Hepatocellular carcinoma 14
cardiomyopathy 14
liver disease 14
coronary artery disease 13
SDS 13
pheochromocytoma 13
depression 13
liver fibrosis 13
AIDS 13
Wright 12
amyotrophic lateral sclerosis 12
HCC 12
hyperglycemia 12
hepatitis C 12
acute leukemia 12
plaque 12
primary tumor 12
cowpox 11
Osteosarcoma 11
Osteosarcoma 11
dermatitis 11
fibrosarcoma 11
arthritis 11
hepatitis B 11
cirrhosis 11
osteoporosis 11
esophageal cancer 11
sarcoma 11
Ewing's sarcoma 10
osteoarthritis 10
encephalomyelitis 10
malignant mesothelioma 10
cognitive impairment 10
Hodgkin's disease 10
Shiga 10
small cell lung cancer 10
PML 10
hematologic malignancies 10
ulcerative colitis 10
glaucoma 10
chronic obstructive pulmonary disease 9
NAME 9
anemia 9
PHA 9
renal ischemia 9
molluscum contagiosum 9
thyroid cancer 9
adult T-cell leukemia/lymphoma 9
Melanoma 9
cholestasis 9
immunotoxicity 9
cardiovascular disease 8
more...
Symptom
collapse 43
starvation 17
seizures 14
hypothermia 11
splenomegaly 9
functional recovery 8
diarrhea 8
hyperoxia 7
pain 6
anesthesia 5
exhaustion 4
headache 3
skin damage 3
weakness 3
dry eye 3
memory loss 3
cachexia 3
insomnia 3
thinning 3
respiratory distress 3
menopausal symptoms 2
tremor 2
sore throat 2
overweight 2
abdominal pain 2
nausea and vomiting 1
nausea 1
ataxia 1
loss of balance 1
hot flashes 1
discomfort 1
acidity 1
HSA 1
acute stress 1
dizziness 1
back pain 1
ataxic gait 1
sleepiness 1
dyspnea 1
alexithymia 1
erythema 1
dystonia 1
low back pain 1
syncope 1
flushing 1
hyperemesis 1
myalgia 1
bradypnea 1
halitosis 1
discomfort 1
tinnitus 1
Tenderness 1
Drug
ROS 149
IL-2 41
IFN-gamma 39
Bortezomib 29
Dermatol 25
p75 23
vitamin E 21
lysine 20
ascorbate 17
Taxol 16
Monit 15
IFN-beta 13
Cardiovasc 11
CED 11
Arsenic trioxide 10
ADR 10
CSF 10
caffeine 9
Ethanol 9
MAP 9
Glycyrrhiza 8
Flavopiridol 8
Mutagen 8
Sorafenib 7
MRC 7
Etoposide 7
2-Methoxyestradiol 6
-deoxyadenosine 6
G-CSF 6
Propofol 6
CTX 6
CCL 5
Vitamin E 5
ICI 4
EE2 4
lactose 4
AMC 4
NVP 4
Angiotensin II 4
Ginseng 4
Emodin 4
Epigallocatechin 4
Indomethacin 4
Glutathione 4
Emodin 4
CPT-11 4
ALA 4
Triad 3
Cantor 3
Amiloride 3
CTX 3
Triad 3
DHT 3
Hyperforin 3
Glucagon 3
Docetaxel 3
CoCl2 3
DHT 3
Vorinostat 3
CoCl2 3
TAT 3
Dasatinib 3
Radicicol 3
ADM 3
CTX 3
Vitamin A 3
Simvastatin 3
EPA 3
Vitamin B 3
Trabectedin 3
PCB 2
Bosentan 2
NADH 2
Dial 2
Parkin 2
Parkin 2
Isoniazid 2
Thioridazine 2
Ouabain 2
Swainsonine 2
Retinoic acid 2
Naftopidil 2
Artesunate 2
Vitamin K 2
Asn 2
Leaf 2
Heme 2
Colistin 2
Mevastatin 2
Pravastatin 2
Triclosan 2
Bosentan 2
Sodium ascorbate 2
Growth hormone 2
Oxaliplatin 2
Rolipram 2
CA-074 2
PFT 2
Fraction 2
Propidium 2
Lovastatin 2
Paraffin 2
Edratide 2
Growth hormone 2
ID2 2
ABC 2
Fragment 2
Fluorescein 2
Rosiglitazone 2
citric acid 2
PTC 2
TTC 2
Adriamycin 2
Lonafarnib 1
VCR 1
Olmesartan 1
Zoledronic acid 1
DPA 1
Alexidine 1
BH4 1
TAC 1
Onconase 1
ACT 1
Rasburicase 1
Dihydro 1
Bucillamine 1
Cimetidine 1
Erlotinib 1
Meth 1
Gefitinib 1
Lenalidomide 1
Olomoucine 1
Etodolac 1
Calcium chloride 1
TAK 1
Bifidobacterium 1
Orlistat 1
Everolimus 1
Activin 1
Lexatumumab 1
Voltaren 1
Portal 1
Geranium 1
Adenosine triphosphate 1
ETS 1
Monensin 1
Nephron 1
TMS 1
HPMPC 1
Infliximab 1
Poloxamer 188 1
Berberine chloride 1
Zebularine 1
Revlimid 1
Apomorphine 1
Photofrin 1
ZnCl2 1
Troglitazone 1
DBS 1
Mizoribine 1
more...
Enzyme
caspase-8 6833
caspase-3 3091
caspase-9 1965
PARP 625
mitogen-activated protein kinase 613
caspase-1 245
ERK 223
protein kinase 164
caspase-2 156
caspase-2 155
caspase-7 142
caspase-7 138
proteasome 123
superoxide dismutase 115
caspase-10 114
catalase 114
caspase-10 110
caspase-6 99
caspase-6 96
protein kinase C 80
focal adhesion kinase 71
MEK 68
luciferase 58
lactate dehydrogenase 58
cdc2 56
caspase-4 48
phosphatidylinositol 3-kinase 48
caspase-4 47
IKK 42
glutathione peroxidase 36
granzyme B 36
calcineurin 35
alanine aminotransferase 34
cathepsin B 30
caspase-11 28
aspartate aminotransferase 28
caspase-11 28
TdT 27
ATPase 27
RNase 26
RNase 26
glutathione S-transferase 26
P-glycoprotein 25
GSK 24
peroxidase 23
topoisomerase 21
AMP-activated protein kinase 21
phosphoinositide 3-kinase 21
topoisomerase 21
MMP 20
NADPH oxidase 19
reverse transcriptase 19
NADPH oxidase 18
succinate dehydrogenase 18
glutathione reductase 18
NO synthase 17
Omi/HtrA2 17
complex I 16
cathepsin D 15
alkaline phosphatase 15
phospholipase C 12
trypsin 12
NOS 12
AMPK 11
protein phosphatase 2A 11
RNA polymerase 10
collagenase 10
tyrosine hydroxylase 10
AMPK 10
ECH 9
CAD 9
ribonuclease 9
ribonuclease 9
CAD 9
CAD 9
AST 8
DNA ligase 8
DNA ligase 8
ribonucleotide reductase 8
ribonucleotide reductase 8
acetylcholinesterase 8
DNase 8
ACS 8
creatine kinase 8
MAP 7
thymidine kinase 7
caspase-5 7
m-calpain 7
neutral sphingomyelinase 7
renin 6
caspase-5 6
myosin light chain kinase 6
glutamine synthetase 6
PDK1 6
p100 6
APC 6
mu-calpain 6
endonuclease 6
phosphodiesterase 6
neuraminidase 5
sphingosine kinase 5
MPP 5
MEKK1 5
MMP-3 5
peroxiredoxin 5
farnesyltransferase 5
transcriptase 5
choline acetyltransferase 4
hyaluronidase 4
hyaluronidase 4
paraoxonase 4
adenylate cyclase 4
ACE 4
TOR 4
farnesyltransferase 4
MDR 4
prostate-specific antigen 4
transglutaminase 4
xanthine oxidase 4
TAT 3
nucleotidase 3
ceramidase 3
MIP 3
DCF 3
aldehyde dehydrogenase 3
IMP dehydrogenase 3
S-adenosylmethionine decarboxylase 3
DNA methyltransferase 3
PKG 3
lipoxygenase 3
neutrophil elastase 3
phospholipase A2 3
sphingomyelin synthase 3
chymotrypsin 3
ricin 3
polo-like kinase 1 3
CPT 3
cholesterol acyltransferase 3
lysyl-tRNA synthetase 3
gamma-glutamylcysteine synthetase 3
apyrase 3
urokinase-type plasminogen activator 3
ornithine decarboxylase 3
CPT 3
TSP-1 3
arginase 3
CD10 3
triphosphatase 3
gamma-glutamyl transpeptidase 3
heme oxygenase 3
acid phosphatase 3
CPT 3
HSD 2
NQO1 2
arginine deiminase 2
guanylate cyclase 2
BMT 2
adenosine deaminase 2
histone acetyltransferase 2
acetyl-CoA carboxylase 2
more...
Compound
DNA 1148
oxygen 674
Dec 527
TNF 421
MTT 288
cysteine 249
Asp 177
MDA 157
dUTP 142
GSH 130
GSH 130
calcium 127
iodine 124
alanine 113
ADP-ribose 107
Clin 102
ATP 90
nitric oxide 90
N-acetylcysteine 88
glucose 87
boron 82
bromide 78
serine 77
water 75
threonine 67
sodium 66
tyrosine 59
hydrogen 59
ADP 54
ADP 52
ADP 51
ethanol 49
acetate 47
Ile 43
Curcumin 41
THP 41
MEK 41
THP 41
leucine 39
DDP 38
Cytochrome c 37
H2O2 36
ADR 36
acridine 36
ASC 34
Cyt 30
ethyl acetate 30
NH2 30
zinc 29
Adriamycin 29
phosphate 28
retinoic acid 28
Hoechst 33342 28
glutamate 27
arginine 27
Panam 26
aldehyde 24
sulfate 24
His 23
lysine 23
nitrogen 22
cadmium 22
aldehyde 22
galactose 20
5-FU 19
cAMP 18
aspartic acid 18
Pac 18
selenium 18
hexane 18
urea 17
glutamine 17
diacetate 17
CAT 17
CAT 17
CAT 17
aspartic acid 17
aspartic acid 17
aspartic acid 17
copper 16
methanol 15
proline 15
MTS 15
dATP 15
PEG 14
salt 14
Resveratrol 14
Phe 14
iron 14
DMSO 14
Paclitaxel 13
PMA 13
anthracene 13
PMA 13
celastrol 13
potassium 13
Neuronal 13
Sulforaphane 12
Quercetin 12
TOF 12
NAD 12
SDS 12
Cer 12
Apigenin 12
Celastrol 11
piperazine 11
NAD 11
tryptophan 11
creatinine 11
VP-16 11
ATF 11
methionine 11
manganese 11
gallic acid 10
Tanshinone 10
Berberine 10
Ursolic acid 10
pyrrolidine 10
PEG 10
APO 10
GSSG 10
DPPH 10
nicotinamide 10
Cereb 10
caffeine 9
tryptophan 9
chalcone 9
UTP 9
tryptophan 9
pyrimidine 9
tryptophan 9
Luteolin 9
Insulin 9
pyrimidine 9
Dexamethasone 9
kaempferol 9
8-OHdG 9
CO2 9
Gly 9
AMP 9
Cordycepin 8
Cardiol 8
Triptolide 8
NOXA 8
Tumor Necrosis Factor 8
Cordycepin 8
pyrrolidine 8
MIA 8
Silymarin 8
ACS 8
indole-3-carbinol 8
cobalt 8
Cycloheximide 8
PGE 8
5-Aza-2'-deoxycytidine 8
Actinomycin D 8
TEM 8
Cordycepin 8
cGMP 8
ACS 8
more...