Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.61 (
caspase-8
)
6,833
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The upregulation of
EPH receptor B4
(
EPHB4
) results in a survival advantage for tumor cells via the inhibition of the casapse-8-mediated apoptotic pathway, which begins from the cell membrane. The present study investigated the expression patterns of
EPHB4
, ephrin B2
(EFNB2)
and
caspase-8
in patients with esophageal squamous cell carcinoma (ESCC). The association between the expression patterns and certain clinicopathological characteristics of the patients was also determined. mRNA levels of
EPHB4, EFNB2
and
caspase-8
in paired primary ESCC samples and adjacent esophageal tissues collected from 96 patients with ESCC were quantified using quantitative PCR. Upregulation of
EPHB4
and
EFNB2
mRNA expression, and downregulation of
caspase-8
mRNA were detected in ESCC samples compared with that in the adjacent esophageal tissues. The expression levels of
EPHB4
and
EFNB2
were positively correlated with each other, whereas the mRNA levels of both
EPHB4
and
EFNB2
exhibited a negative correlation with that of
caspase-8
. The mRNA levels of both
EPHB4
and
EFNB2
demonstrated a significant positive association with certain clinicopathological features of patients with ESCC, including family history, tumor size, metastasis and stage. Conversely, a negative association was revealed between the expression level of
caspase-8
and clinicopathological features of patients with ESCC. Moreover, mRNA expression levels of
EPHB4
and
EFNB2
were negatively associated with survival times of patients with ESCC, whereas the level of
caspase-8
was positively associated with patient outcome. The results from the present study suggested that
EPHB4, EFNB2
and
caspase-8
may be implicated in the tumorigenesis and progression of ESCC, and that consequently, they may serve as useful prognostic markers, as well as potential therapeutic targets.
...
PMID:Expression levels of
EPHB4, EFNB2
and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer. 3188 20
