Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.61 (
caspase-8
)
6,833
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression of
DCC
(deleted in colorectal cancer) is often markedly reduced in colorectal and other cancers. However, the rarity of point mutations identified in
DCC
coding sequences and the lack of a tumor predisposition phenotype in
DCC
hemizygous mice have raised questions about its role as a tumor suppressor.
DCC
also mediates axon guidance and functions as a dependence receptor; such receptors create cellular states of dependence on their respective ligands by inducing apoptosis when unoccupied by ligand. We now show that
DCC
drives cell death independently of both the mitochondria-dependent pathway and the death receptor/
caspase-8
pathway. Moreover, we demonstrate that
DCC
interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 without a requirement for cytochrome c or Apaf-1. Hence,
DCC
defines an additional pathway for the apoptosome-independent caspase activation.
...
PMID:The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. 1124 93
