Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.61 (
caspase-8
)
6,833
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To investigate the clinical effects of EH0202, a Japanese herbal supplement, on the
menopausal symptoms
and physical status of peri- and post-menopausal women. Thirty-two post-menopausal women (53.0+/-5.1 years) presented with menopausal complaints were enrolled in the clinical study. Patients were administered an herbal supplement, EH0202 (6 g/day for 6 months), and were assessed for improvement of their overall symptoms using the Greene Climacteric Scale and the Visual Analog Scale (VAS). Blood pressure, skin surface blood flow and plasma lipid profiles were measured before and 1,3 and 6 months after EH0202 administration. There was a significant decrease in the climacteric scale score (P < 0.001) and VAS (P < 0.0001) after 6 months of EH0202 treatment. There was a significant decrease in systolic (P < 0.001) and diastolic (P < 0.05) blood pressure, and a significant decrease in facial skin surface blood flow (P < 0.05) after 3 months of EH0202 administration. We observed a significant decrease in plasma TG and LDL-cholesterol concentrations after 3 months of EH0202 administration (P < 0.05). EH0202 (
MACH
) reduced blood pressure, excess facial skin blood flow (flushing) and abnormal lipid levels, as well as clinically improved
menopausal symptoms
in post-menopausal women. In post-menopausal women, this product appears to help maintain normal biological function and improves quality of life.
...
PMID:Clinical efficacy of EH0202, a Kampo formula, on the health of middle-aged women. 1563 10
Gami-soyosan is a medicinal herbal formulation prescribed for the treatment of
menopausal symptoms
, including hot flashes and osteoporosis. Gami-soyosan is also used to treat similar symptoms experienced by patients with breast cancer. The incidence of breast cancer in women receiving hormone replacement therapy is a big burden. However, little is known about the components and their mechanism of action that exhibit these beneficial effects of Gami-soyosan. The aim of this study was to simultaneously analyze compounds of Gami-soyosan, and determine their cytotoxic effects on estrogen receptor (ER)-positive MCF-7 human breast adenocarcinoma cells. We established a simultaneous analysis method of 18 compounds contained in Gami-soyosan and found that, among the various compounds in Gami-soyosan, gallic acid (
1
), decursin (
17
), and decursinol angelate (
18
) suppressed the viability of MCF-7 cells. Gallic acid (
1
), decursin (
17
), and decursinol angelate (
18
) induced apoptotic cell death and significantly increased poly (ADP-ribose) polymerase (PARP) cleavage and the Bcl-2-associated X protein/ B-cell lymphoma 2 (Bax/Bcl-2) ratio. Decursin (
17
) increased the expression of cleaved caspases-8, -9, -7, and -3. Decursinol angelate (
18
) increased the expression of cleaved
caspase-8
and -7. These three components altered the different apoptosis signal pathways. Collectively, gallic acid (
1
), decursin (
17
), and decursinol angelate (
18
) may be used to inhibit cell proliferation synergistically in patients with ER-positive breast cancer.
...
PMID:Analysis and Identification of Active Compounds from Gami-Soyosan Toxic to MCF-7 Human Breast Adenocarcinoma Cells. 3129 70
