Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.61 (
caspase-8
)
6,833
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The emerging evidences suggest that endoplasmic (ER) stress is involved in onset of many pathological conditions like cancer and neurodegeneration. The persistent ER stress results in misfolded protein aggregates, which are degraded through the process of autophagy or lead to cell death through activation of caspases. The regulation of crosstalk of autophagy and cell death during ER stress is emerging. Ubiquitination plays regulatory role in crosstalk of autophagy and cell death. In the current study, we describe the role of
TRIM13
, RING E3 ubiquitin ligase, in regulation of ER stress induced cell death. The expression of
TRIM13
sensitizes cells to ER stress induced death.
TRIM13
induced autophagy is essential for ER stress induced caspase activation and cell death.
TRIM13
induces K63 linked poly-ubiquitination of
caspase-8
, which results in its stabilization and activation during ER stress.
TRIM13
regulates translocation of
caspase-8
to autophagosome and its fusion with lysosome during ER stress. This study first time demonstrated the role of
TRIM13
as novel regulator of
caspase-8
activation and cell death during ER stress.
...
PMID:TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death. 2402 Dec 63
