Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.61 (
caspase-8
)
6,833
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Malignant rhabdoid tumor
(
MRT
) is a rare and highly aggressive tumor presenting in the kidney and soft tissue in childhood. However, effective treatment for
MRT
has not been established. We investigated the antitumor effect of etodolac, a selective cyclooxygenase-2 inhibitor, on
MRT
cells in vitro using the
MRT
cell line FRTK-1. Etodolac induced apoptosis of FRTK-1 cells through activation of
caspase-8
, -9 and -3. Moreover, several caspase inhibitors completely or partially inhibited etodolac-induced apoptosis. Our data indicated that etodolac had an antitumor effect on
MRT
cells and holds promise as a novel therapeutic strategy for
MRT
.
...
PMID:Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). 1714 95
