Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.60 (caspase-7)
 920 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-3 539
caspase-9 230
PARP 163
Bcl-2 151
caspase-8 146
cytochrome c 109
p53 97
Mol 90
poly(ADP-ribose) polymerase 68
Sep 59
endoplasmic reticulum 57
caspase 7 51
p21 49
Fas 48
Bid 40
annexin V 38
p38 34
inhibitor of apoptosis 32
XIAP 30
JNK 27
ERK 26
bax 25
poly (ADP-ribose) polymerase 25
calpain 25
CPP32 24
cytokine 23
TNF 23
Bak 22
survivin 21
bcl-2 21
cyclin D1 21
GRP78 20
AKT 20
CHOP 20
MAPK 20
p27 20
Smac 18
ERK1 18
Apaf-1 17
granzyme B 17
ADP 16
LC3 16
ATP 16
mTOR 16
Mcl-1 16
caspase 6 15
glucose-regulated protein 15
proteasome 14
PARP-1 14
ROS 14
FasL 13
c-Jun 13
CDK2 13
Tumor necrosis factor 13
cysteine protease 13
PERK 12
CMH-1 12
tumor necrosis factor 12
Fas ligand 12
p65 11
apoptosis-inducing factor 11
X-linked inhibitor of apoptosis protein 11
estrogen receptor 11
FADD 11
anti-apoptotic protein 10
cytochrome 10
pro-apoptotic protein 10
cIAP2 10
DIABLO 10
tyrosine kinase 10
PI3K 10
NMR 10
CDK6 10
IAP2 10
MEK 10
histone deacetylase 10
CDK4 9
cyclin A 9
CD95 9
catalase 9
PC-3 9
C/EBP homologous protein 9
proliferating cell nuclear antigen 9
Ki-67 8
epidermal growth factor receptor 8
p38 mitogen-activated protein kinase 8
collagen 8
dimeric 8
ubiquitin 8
interferon 8
cyclin E 8
cyclin 7
ICE 7
p23 7
IL-6 7
ICAD 7
GSH 7
lactate dehydrogenase 7
PKC 7
IL-8 7
cyclin B1 7
TNF-alpha 7
PC3 7
p20 7
HSP70 7
histone 7
proteasome inhibitor 7
superoxide dismutase 7
PTEN 7
DR5 6
perforin 6
CED 6
LDH 6
Beclin-1 6
MEK1 6
p12 6
TdT 6
DR4 6
BiP 6
ATF6 6
polypeptide 6
H2AX 6
p62 6
lipopolysaccharide 6
heat shock protein 6
IAP 6
BAX 6
MAP 6
p17 6
caspase 2 6
Bax protein 6
ACS 6
SOD 6
NLRC4 6
ASC 5
IFN 5
cyclin-dependent kinase 5
AGS 5
EGFR 5
p35 5
extracellular signal-regulated kinase 5
AIF 5
glutathione peroxidase 5
GSK 5
LPS 5
Caspase-1 5
MTS 5
glial fibrillary acidic protein 5
ATF4 5
IFN-gamma 5
p18 5
35 kDa 5
Poly 5
Chk1 5
CD40 5
E2F1 5
TRAIL-R1 5
endonuclease 4
MMP9 4
ESI 4
inducible nitric oxide synthase 4
serum albumin 4
p38MAPK 4
catenin 4
gasdermin D 4
FLICE 4
BCL2 4
amyloid precursor protein 4
c-Myc 4
mitogen-activated protein 4
ATF 4
STAT3 4
BAK 4
glutathione reductase 4
HDAC 4
Cytokine 4
UTR 4
lamin A 4
Histone deacetylase 4
BAD 4
JNK1 4
TRAIL 4
lymphoid 4
BRAF 4
VEGFR2 4
PUMA 4
insulin 4
IRE1 4
TLR4 4
5-lipoxygenase 4
Cytochrome c 4
PARP1 4
serine protease 4
Hsp90 4
Bcl-X 4
ataxin-7 4
ACHN 4
cathepsin G 4
CD95L 4
TLR2 4
IL-18 4
CASP7 4
ATPase 4
brain-derived neurotrophic factor 4
PKR 4
CCAAT/enhancer-binding protein homologous protein 4
IL-15 3
cathepsin D 3
vascular endothelial growth factor receptor 3
calnexin 3
p19 3
p10 3
cyclooxygenase 2 3
VEGF 3
c-myc 3
BID 3
IL-2 3
GADD45 3
HDAC1 3
neuronal apoptosis inhibitory protein 3
DNase 3
eukaryotic translation initiation factor 3
phosphoinositide 3-kinase 3
interferon regulatory factor-1 3
cyclin dependent kinase 3
interleukin-6 3
BOD 3
mdm2 3
RNase 3
osteosarcoma 3
bcl-x 3
glutathione S-transferase 3
TNF-R1 3
WAF1 3
rhodopsin 3
protein disulfide isomerase 3
claudin-12 3
manganese superoxide dismutase 3
Pseudomonas 3
HDAC3 3
LC3B 3
huntingtin 3
FOXO3 3
IRF-1 3
XBP1 3
occludin 3
carp 3
MDM2 3
Raji 3
kit 3
glycoprotein 3
NOD 3
endonuclease G 3
plasminogen 3
APO-1 3
apoptosis inhibitor 3
IRE 3
X-chromosome 3
matrix metalloproteinase 3
FLIP 3
P21 3
aromatase 3
CASP-9 3
IkappaBalpha 3
serine/threonine kinase 3
aspartate aminotransferase 3
calmodulin 3
protein phosphatase 3
LOX 3
IL-1 3
p42 3
collecting duct 3
MAP kinase 3
tumor necrosis factor receptor 3
cyclooxygenase-2 3
ATG5 3
CDK1 3
ankyrin 3
extracellular signal-regulated kinase 1 3
Spinocerebellar ataxia type 7 3
DNA damage-inducible protein 3
fibronectin 3
calpastatin 3
NEDD8 3
A431 3
MOLT 3
calreticulin 3
MMP-2 3
NF-E2-related factor 2 3
RhoA 3
protein kinase inhibitor 3
phosphatase and tensin homolog 3
thrombin 3
cIAP1 3
p21 protein 3
NADPH 3
microsomal 3
Bik 3
PKB 3
HER2 3
E-cadherin 3
reductase 3
gut 2
GST 2
CASP8 2
MMP-9 2
calpain inhibitor 2
phospholipase 2
amyloid beta 2
Rho 2
c-myc mRNA 2
PI-3 kinase 2
12-LOX 2
p44 2
GRP 2
CDC2 2
metallopeptidase 2
all-trans 2
cyclin-dependent kinase inhibitor 2
XBP-1 2
more...
Disease
cancer 258
tumor 150
MCF 119
breast cancer 105
carcinoma 35
tumor growth 30
colon cancer 27
leukemia 24
hepatocellular carcinoma 23
carcinogenesis 22
prostate cancer 20
B-cell lymphoma 19
lung cancer 19
adenocarcinoma 18
glioma 17
colorectal cancer 17
tumorigenesis 15
Alzheimer's disease 13
ischemia 12
lymphoma 12
squamous cell carcinoma 12
neuroblastoma 10
melanoma 10
tumor progression 10
gastric cancer 9
acute myeloid leukemia 9
pancreatic cancer 9
renal cell carcinoma 8
non-small cell lung cancer 8
liver cancer 8
cervical cancer 8
Blocking 8
esophageal cancer 7
retinoblastoma 7
esophageal cancer 7
GSH 7
multiple myeloma 6
Parkinson's disease 6
Kaposi's sarcoma 6
liver cancer 6
stroke 6
infectious diseases 5
glioblastoma 5
skin cancer 5
ovarian cancer 5
bladder cancer 5
MTS 5
Legionella 5
AGS 5
solid tumor 5
influenza 5
DDP 5
acute promyelocytic leukemia 5
glioblastoma multiforme 4
diabetes 4
Hepatocellular carcinoma 4
virus infection 4
lung carcinoma 4
chronic myeloid leukemia 4
hepatitis C 4
myocardial ischemia 4
epithelial ovarian cancer 4
HIV 4
fibrosarcoma 4
sepsis 3
liver fibrosis 3
amyotrophic lateral sclerosis 3
pheochromocytoma 3
endometrial cancer 3
muscular atrophy 3
metastases 3
sepsis 3
heart failure 3
cowpox 3
NOD 3
AIDS 3
osteosarcoma 3
myocardial infarction 3
Huntington's disease 3
pneumonia 3
hepatitis 3
Infection 3
cerebral ischemia 3
atherosclerosis 2
chronic lymphocytic leukemia 2
cold 2
dementia 2
myeloid leukemia 2
herpes 2
hyperosmolality 2
herpes simplex 2
Pineal 2
Primary effusion lymphoma 2
Leukemia 2
cirrhosis 2
mammary tumor 2
fatty liver 2
mesothelioma 2
hypoglycemia 2
head and neck cancer 2
APC 2
salmonellosis 2
HCC 2
stomatitis 2
papillary thyroid cancer 2
coronary artery disease 2
retinitis pigmentosa 2
acute renal failure 2
Melanoma 2
cholera 2
diabetic retinopathy 2
oral cancer 2
acute myocardial infarction 2
Glioblastoma 2
ATM 2
hypertension 2
autoimmune disease 2
arthritis 2
medulloblastoma 2
chronic lymphocytic leukemia 2
brain cancer 2
rheumatoid arthritis 2
acute lymphoblastic leukemia 2
systemic lupus erythematosus 2
thyroid cancer 2
primary tumor 2
aggressiveness 2
metastatic breast cancer 2
DMS 2
ABL 2
brain tumor 2
cardiovascular disease 2
Hippel 2
ductal carcinoma 2
epilepsy 2
Aleutian disease 1
malignant mesothelioma 1
uterus 1
lupus 1
infertility 1
autism 1
stromal tumors 1
Cryptococcus neoformans 1
male infertility 1
Pancreas 1
SCID 1
acute pancreatitis 1
inflammatory bowel disease 1
DWI 1
glomerulopathy 1
renal failure 1
bacterial infection 1
gastrointestinal stromal tumor 1
plaque 1
uveitis 1
Reovirus infection 1
premature ovarian failure 1
abortion 1
hematologic malignancies 1
Neuroblastoma 1
MICA 1
vaccinia 1
Foot-and-mouth disease 1
sleep apnea 1
avian influenza 1
SDS 1
metastatic melanoma 1
ovarian neoplasm 1
non-Hodgkin's lymphoma 1
Autism 1
Hodgkin's disease 1
CHN 1
renal ischemia 1
DBM 1
adenoma 1
mental retardation 1
scurvy 1
amok 1
dyskinesia 1
essential hypertension 1
Chondrosarcoma 1
Klebsiella 1
Adhesion 1
graft-versus-host disease 1
dysplasia 1
Chondrosarcoma 1
Autism spectrum disorder 1
ICP 1
liver disease 1
malaria 1
viremia 1
NS3 1
ear disease 1
metabolic syndrome 1
hormone refractory prostate cancer 1
scleroderma 1
MAS 1
Medulloblastoma 1
prostatic disease 1
drug withdrawal 1
keratosis 1
Chlamydia 1
FAS 1
osteoarthritis 1
proteinuria 1
obstructive sleep apnea 1
WRN 1
renal disease 1
coronary occlusion 1
hyperglycemia 1
TAS 1
bone cancer 1
PCD 1
TEM 1
Pancreas 1
ventricular hypertrophy 1
malnutrition 1
pertussis 1
renal cyst 1
polycystic kidney 1
Crohn's disease 1
cytomegalovirus 1
TEM 1
occupational disease 1
multiple sclerosis 1
primary pulmonary hypertension 1
sarcoma 1
suicide 1
LAP 1
adenocarcinoma of the lung 1
subacute sclerosing panencephalitis 1
cognitive impairment 1
immunodeficiency 1
Testicular Cancer 1
AO2 1
encephalomyelitis 1
FBS 1
chondrosarcoma 1
mole 1
residual disease 1
stage III endometrial cancer 1
aggression 1
myelitis 1
TAM 1
chronic obstructive pulmonary disease 1
carcinoma in situ 1
Proteinuria 1
memory impairment 1
Colon cancer 1
endometritis 1
Giant cell tumor of bone 1
Ewing's sarcoma 1
gastrointestinal cancer 1
Epstein 1
AIN 1
Neuroblastoma 1
Syndrome 1
B-cell lymphomas 1
ash 1
STS 1
testicular cancer 1
Chagas 1
CMH1 1
rare disease 1
myositis 1
Ureteral obstruction 1
lymphosarcoma 1
parkinsonism 1
multiple disorders 1
lupus 1
enterocolitis 1
ICS 1
laryngeal squamous cell carcinoma 1
liver metastases 1
HSP 1
endotoxic shock 1
hepatitis B 1
achromatopsia 1
Esophageal squamous cell carcinoma 1
mastitis 1
CTX 1
Cushing's disease 1
diphtheria 1
diabetic cardiomyopathy 1
mental retardation 1
fits 1
CEM 1
OHD 1
mole 1
periodontitis 1
MDD2 1
Symptom
starvation 3
seizures 2
functional recovery 2
hypothermia 1
hypercapnia 1
hyperoxia 1
pain 1
headache 1
neuralgia 1
erythema 1
Drug
ROS 14
lysine 8
MAP 6
CED 6
IFN-gamma 5
Arsenic trioxide 4
Taxol 3
IL-2 3
Sorafenib 3
ZnO 2
IFN-beta 2
CTX 2
ACT 2
AMC 2
ICI 2
Dermatol 2
NVP 2
ADR 1
TFT 1
Fulvestrant 1
Compound 18 1
Estrogens 1
Nitric Oxide 1
CPT-11 1
Clopidogrel 1
CTX 1
Purvalanol 1
Rituximab 1
Spiegel 1
Biopolymers 1
Adriamycin 1
Nephron 1
Cardiovasc 1
Monensin 1
FAD 1
Lovastatin 1
Ketoconazole 1
vitamin E 1
Monit 1
Glycyrrhiza 1
Epigallocatechin 1
PFT 1
Amiloride 1
Phosphatidylserine 1
K-252a 1
Rosiglitazone 1
Nephron 1
Parkin 1
Silica gel 1
Propofol 1
Simvastatin 1
CSF 1
TTC 1
Asn 1
Pravastatin 1
CTX 1
caffeine 1
-deoxyadenosine 1
Fragment 1
Bortezomib 1
Propidium 1
Herceptin 1
Parkin 1
Enzyme
caspase-7 920
caspase-7 896
caspase-3 551
caspase-9 228
PARP 176
caspase-8 142
caspase-6 77
mitogen-activated protein kinase 75
caspase-6 68
caspase-1 54
caspase-2 38
caspase-2 38
ERK 34
protein kinase 18
granzyme B 17
proteasome 14
MEK 14
caspase-4 13
cdc2 12
protein kinase C 12
caspase-4 11
focal adhesion kinase 10
catalase 9
superoxide dismutase 9
lactate dehydrogenase 7
ACS 6
MAP 6
GSK 5
glutathione S-transferase 5
caspase-10 5
glutathione peroxidase 5
caspase-10 5
aspartate aminotransferase 4
NADPH oxidase 4
endonuclease 4
glutathione reductase 4
AMP-activated protein kinase 4
alanine aminotransferase 4
trypsin 4
RNase 4
caspase-5 4
luciferase 4
ATPase 4
NADPH oxidase 3
creatine kinase 3
cathepsin G 3
RNase 3
elastase 3
ECH 3
thrombin 3
calcineurin 3
cathepsin D 3
DNase 3
phospholipase C 3
caspase-11 3
Omi/HtrA2 3
caspase-11 3
topoisomerase 3
phosphoinositide 3-kinase 3
topoisomerase 3
m-calpain 3
reverse transcriptase 3
myosin light chain kinase 3
caspase-5 2
CAD 2
AMPK 2
P-glycoprotein 2
NQO1 2
succinate dehydrogenase 2
thymidylate synthase 2
complex I 2
CAD 2
CAD 2
DNA methyltransferase 2
sphingosine kinase 2
prolyl hydroxylase 2
DNA polymerase 2
IKK 2
peroxiredoxin 2
AMPK 2
mu-calpain 2
aspartase 2
legumain 2
cathepsin B 2
cathepsin L 1
demethylase 1
chitinase 1
cathepsin C 1
DNA ligase 1
cathepsin K 1
polo-like kinase 1 1
ribonuclease 1
deoxycytidine kinase 1
MEKK1 1
firefly luciferase 1
DNA ligase 1
ACE 1
RNase T1 1
neutrophil elastase 1
PTPase 1
ribonuclease 1
SNO 1
glyceraldehyde-3-phosphate dehydrogenase 1
lysozyme 1
beta-glucosidase 1
MAT 1
AST 1
beta-glucosidase 1
subtilisin 1
APC 1
Tpa 1
lipase 1
urokinase-type plasminogen activator 1
prostate-specific antigen 1
MAT 1
TSP-1 1
ALDH 1
Alternating 1
beta-lactamase 1
PHT 1
arginase 1
thermolysin 1
stromelysin-3 1
collagenase 1
monoamine oxidase 1
diamine oxidase 1
phosphatidylinositol 3-kinase 1
acetylcholinesterase 1
peroxidase 1
TdT 1
HSD 1
MDR 1
lipoxygenase 1
MPP 1
adenosine kinase 1
Compound
DNA 155
Dec 77
oxygen 69
cysteine 49
Asp 43
MDA 34
MTT 33
ADP-ribose 26
TNF 23
glucose 23
calcium 20
ADP 18
iodine 17
ADP 16
dUTP 16
ADP 16
ATP 16
tyrosine 15
alanine 14
sodium 13
bromide 13
serine 12
hydrogen 11
MEK 10
N-acetylcysteine 10
aldehyde 9
lysine 9
Clin 9
aldehyde 9
acridine 8
Hoechst 33342 8
water 8
zinc 8
aspartic acid 7
ethyl acetate 7
GSH 7
aspartic acid 7
GSH 7
aspartic acid 7
boron 7
dATP 7
aspartic acid 7
MAP 6
nitrogen 6
glutamate 6
ACS 6
ethanol 6
ACS 6
Acrolein 5
leucine 5
NH2 5
ASC 5
Curcumin 5
chalcone 5
acetate 5
arginine 5
copper 5
threonine 5
kaempferol 5
MTS 5
Paclitaxel 4
ATF 4
phosphate 4
H2O2 4
galactose 4
Cytochrome c 4
DDP 4
glutamic acid 4
COS 4
Melatonin 3
Cer 3
Isoliquiritigenin 3
Phe 3
selenium 3
NAD 3
methionine 3
indole-3-carbinol 3
anthracene 3
iron 3
valine 3
Cordycepin 3
potassium 3
Cordycepin 3
sulfate 3
glutamine 3
Cordycepin 3
NADPH 3
DMSO 3
NADPH 3
5-FU 3
TNM 2
retinoic acid 2
tert-butyl hydroperoxide 2
DBA 2
AMP 2
Neuronal 2
Panam 2
Estrogen 2
Rottlerin 2
PEG 2
fluorine 2
ABL 2
HMG-CoA 2
cGMP 2
DMS 2
Ribose 2
ammonium 2
DMI 2
Oridonin 2
Wortmannin 2
CO2 2
Staurosporine 2
acetic acid 2
Pac 2
naphthoquinone 2
NAD 2
DMI 2
Rottlerin 2
naphthoquinone 2
CTX 2
naphthoquinone 2
salt 2
naphthoquinone 2
Estrogen 2
Gly 2
Foscan 2
DPPH 2
nickel 2
nitric oxide 2
THP 2
silver 2
naphthoquinone 2
Propofol 2
naphthoquinone 2
C-3 2
pyrene 2
MSM 2
COX 2
XTT 2
BCR 2
Adriamycin 2
His 2
5-HETE 2
benzene 2
THP 2
cyanide 2
naphthalene 2
ICI 2
naphthoquinone 2
Rottlerin 2
methanol 2
Quercetin 2
ADR 2
Ile 2
pyridine 2
Staurosporine 2
VP-16 2
dicarboxylic acid 1
DNP 1
12(S)-HETE 1
Dexamethasone 1
Cap 1
formic acid 1
Acacetin 1
formic acid 1
PEG 1
carbonate 1
Serine 1
Chloroquine 1
DPI 1
Decursin 1
Valproic acid 1
Bisphenol A 1
6-Hydroxydopamine 1
Cholesterol 1
chromate 1
2,6-diisopropylphenyl 1
DBM 1
MPT 1
SCC 1
CUE 1
Nitrite 1
RELA 1
DCB 1
Phenylephrine 1
DHA 1
2-butenyl 1
tryptophan 1
Malachite Green 1
Tyrosine 1
TPCK 1
CPT-11 1
Ursolic acid 1
Fisetin 1
beta-Lapachone 1
Sulforaphane 1
proline 1
Aloe-emodin 1
hydroquinone 1
Matrine 1
creatinine 1
NTA 1
phenylacetonitrile 1
Edaravone 1
Naringin 1
acetamide 1
BLM 1
2-oxoglutarate 1
DCB 1
CAN 1
12-hydroxyeicosatetraenoic acid 1
DCP 1
acetamide 1
celastrol 1
Taurine 1
Desipramine 1
Guo 1
isoleucine 1
Phenethyl isothiocyanate 1
stearic acid 1
MPP 1
caffeine 1
Ochratoxin A 1
Cbl 1
isoleucine 1
stearic acid 1
Ferulic acid 1
benzamide 1
Camptothecin 1
ASA 1
tryptophan 1
MPP 1
Deoxynivalenol 1
AMPA 1
PAC 1
Capsaicin 1
PHT 1
[6]-Shogaol 1
CaO 1
2-phenylnaphthalene 1
Oleandomycin 1
DOPAC 1
Pravastatin 1
hydroxycinnamic acid 1
Arsenic 1
Lithium chloride 1
Nordihydroguaiaretic acid 1
Lac 1
Levetiracetam 1
Camptothecin 1
SDS 1
DAP 1
Geldanamycin 1
Propionate 1
Matrine 1
TTC 1
p-Coumaric acid 1
vitamin D 1
formic acid 1
25-dihydroxycholecalciferol 1
hydroxide 1
Brazilin 1
MIA 1
Triton 1
CMP 1
Angiotensin II 1
DCP 1
MDR 1
FK506 1
Epigallocatechin 1
Se-methylselenocysteine 1
TOF 1
Bisphenol A 1
Nitrite 1
thiophene 1
LPR 1
DAP 1
4-chlorophenyl 1
Warfarin 1
FAD 1
APO 1
Cycloheximide 1
Lithium 1
formic acid 1
butyric acid 1
MMD 1
hexadecyl 1
10-Hydroxycamptothecin 1
AFC 1
Safranin O 1
Dopamine 1
3-cyanopyridine 1
DCB 1
Crocin 1
uridine 1
Chloroquine 1
Lovastatin 1
formic acid 1
Statin 1
formic acid 1
tryptophan 1
Hearts 1
TFT 1
mercury 1
Guo 1
Epigallocatechin gallate 1
NMDA 1
Naringin 1
NOXA 1
Ferulic acid 1
Vimentin 1
CoA 1
N-(4-hydroxyphenyl)retinamide 1
Ketoconazole 1
GTP 1
hexane 1
DCB 1
DCB 1
DHA 1
Ethidium bromide 1
more...