Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.60 (caspase-7)
 920 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
caspase-3 539
caspase-9 230
PARP 163
Bcl-2 151
caspase-8 146
cytochrome c 109
p53 97
Mol 90
poly(ADP-ribose) polymerase 68
Sep 59
endoplasmic reticulum 57
caspase 7 51
p21 49
Fas 48
Bid 40
annexin V 38
p38 34
inhibitor of apoptosis 32
XIAP 30
JNK 27
ERK 26
poly (ADP-ribose) polymerase 25
bax 25
calpain 25
CPP32 24
TNF 23
cytokine 23
Bak 22
cyclin D1 21
survivin 21
bcl-2 21
GRP78 20
MAPK 20
p27 20
AKT 20
CHOP 20
ERK1 18
Smac 18
granzyme B 17
Apaf-1 17
ATP 16
ADP 16
Mcl-1 16
mTOR 16
LC3 16
caspase 6 15
glucose-regulated protein 15
proteasome 14
ROS 14
PARP-1 14
Tumor necrosis factor 13
cysteine protease 13
FasL 13
CDK2 13
c-Jun 13
PERK 12
CMH-1 12
Fas ligand 12
tumor necrosis factor 12
p65 11
apoptosis-inducing factor 11
X-linked inhibitor of apoptosis protein 11
FADD 11
estrogen receptor 11
cIAP2 10
cytochrome 10
MEK 10
DIABLO 10
histone deacetylase 10
IAP2 10
pro-apoptotic protein 10
CDK6 10
PI3K 10
NMR 10
tyrosine kinase 10
anti-apoptotic protein 10
cyclin A 9
PC-3 9
CDK4 9
proliferating cell nuclear antigen 9
C/EBP homologous protein 9
CD95 9
catalase 9
cyclin E 8
ubiquitin 8
p38 mitogen-activated protein kinase 8
interferon 8
dimeric 8
collagen 8
Ki-67 8
epidermal growth factor receptor 8
PC3 7
cyclin 7
lactate dehydrogenase 7
histone 7
GSH 7
PKC 7
p23 7
cyclin B1 7
proteasome inhibitor 7
HSP70 7
ICAD 7
TNF-alpha 7
p20 7
ICE 7
IL-8 7
PTEN 7
IL-6 7
superoxide dismutase 7
MAP 6
perforin 6
caspase 2 6
SOD 6
TdT 6
CED 6
DR4 6
LDH 6
DR5 6
Beclin-1 6
H2AX 6
polypeptide 6
p12 6
NLRC4 6
ACS 6
IAP 6
Bax protein 6
BAX 6
heat shock protein 6
p17 6
lipopolysaccharide 6
ATF6 6
p62 6
BiP 6
MEK1 6
IFN 5
glial fibrillary acidic protein 5
ATF4 5
glutathione peroxidase 5
p35 5
TRAIL-R1 5
35 kDa 5
EGFR 5
GSK 5
AGS 5
LPS 5
ASC 5
E2F1 5
cyclin-dependent kinase 5
CD40 5
Chk1 5
extracellular signal-regulated kinase 5
Caspase-1 5
Poly 5
IFN-gamma 5
p18 5
AIF 5
MTS 5
IRE1 4
ATF 4
5-lipoxygenase 4
more...
Disease
cancer 258
tumor 150
MCF 119
breast cancer 105
carcinoma 35
tumor growth 30
colon cancer 27
leukemia 24
hepatocellular carcinoma 23
carcinogenesis 22
prostate cancer 20
lung cancer 19
B-cell lymphoma 19
adenocarcinoma 18
glioma 17
colorectal cancer 17
tumorigenesis 15
Alzheimer's disease 13
ischemia 12
squamous cell carcinoma 12
lymphoma 12
neuroblastoma 10
tumor progression 10
melanoma 10
pancreatic cancer 9
acute myeloid leukemia 9
gastric cancer 9
renal cell carcinoma 8
liver cancer 8
Blocking 8
non-small cell lung cancer 8
cervical cancer 8
esophageal cancer 7
esophageal cancer 7
retinoblastoma 7
GSH 7
Parkinson's disease 6
stroke 6
Kaposi's sarcoma 6
liver cancer 6
multiple myeloma 6
influenza 5
solid tumor 5
DDP 5
glioblastoma 5
infectious diseases 5
MTS 5
bladder cancer 5
ovarian cancer 5
Legionella 5
skin cancer 5
acute promyelocytic leukemia 5
AGS 5
HIV 4
glioblastoma multiforme 4
diabetes 4
hepatitis C 4
chronic myeloid leukemia 4
Hepatocellular carcinoma 4
epithelial ovarian cancer 4
lung carcinoma 4
virus infection 4
fibrosarcoma 4
myocardial ischemia 4
Huntington's disease 3
cowpox 3
pneumonia 3
cerebral ischemia 3
sepsis 3
liver fibrosis 3
pheochromocytoma 3
metastases 3
hepatitis 3
sepsis 3
AIDS 3
NOD 3
muscular atrophy 3
heart failure 3
myocardial infarction 3
osteosarcoma 3
endometrial cancer 3
amyotrophic lateral sclerosis 3
Infection 3
hypertension 2
medulloblastoma 2
dementia 2
cardiovascular disease 2
ABL 2
aggressiveness 2
hyperosmolality 2
Pineal 2
Primary effusion lymphoma 2
Leukemia 2
herpes simplex 2
cirrhosis 2
mammary tumor 2
chronic lymphocytic leukemia 2
myeloid leukemia 2
fatty liver 2
hypoglycemia 2
metastatic breast cancer 2
acute lymphoblastic leukemia 2
cold 2
autoimmune disease 2
chronic lymphocytic leukemia 2
salmonellosis 2
atherosclerosis 2
epilepsy 2
ATM 2
ductal carcinoma 2
herpes 2
papillary thyroid cancer 2
brain cancer 2
retinitis pigmentosa 2
coronary artery disease 2
Melanoma 2
primary tumor 2
rheumatoid arthritis 2
DMS 2
arthritis 2
diabetic retinopathy 2
Glioblastoma 2
acute myocardial infarction 2
cholera 2
stomatitis 2
HCC 2
oral cancer 2
acute renal failure 2
APC 2
systemic lupus erythematosus 2
thyroid cancer 2
head and neck cancer 2
mesothelioma 2
Hippel 2
brain tumor 2
Aleutian disease 1
malignant mesothelioma 1
uterus 1
infertility 1
Cryptococcus neoformans 1
male infertility 1
acute pancreatitis 1
inflammatory bowel disease 1
parkinsonism 1
DWI 1
gastrointestinal stromal tumor 1
plaque 1
uveitis 1
abortion 1
hematologic malignancies 1
MICA 1
vaccinia 1
Foot-and-mouth disease 1
sleep apnea 1
avian influenza 1
SDS 1
metastatic melanoma 1
ovarian neoplasm 1
non-Hodgkin's lymphoma 1
Autism 1
more...
Symptom
starvation 3
seizures 2
functional recovery 2
hypothermia 1
hypercapnia 1
hyperoxia 1
pain 1
headache 1
neuralgia 1
erythema 1
Drug
ROS 14
lysine 8
MAP 6
CED 6
IFN-gamma 5
Arsenic trioxide 4
Taxol 3
IL-2 3
Sorafenib 3
ZnO 2
IFN-beta 2
CTX 2
ACT 2
AMC 2
ICI 2
Dermatol 2
NVP 2
ADR 1
TFT 1
Fulvestrant 1
Compound 18 1
Estrogens 1
Nitric Oxide 1
CPT-11 1
Clopidogrel 1
CTX 1
Purvalanol 1
Rituximab 1
Spiegel 1
Biopolymers 1
Adriamycin 1
Nephron 1
Cardiovasc 1
Monensin 1
FAD 1
Lovastatin 1
Ketoconazole 1
vitamin E 1
Monit 1
Glycyrrhiza 1
Epigallocatechin 1
PFT 1
Amiloride 1
Phosphatidylserine 1
K-252a 1
Rosiglitazone 1
Nephron 1
Parkin 1
Silica gel 1
Propofol 1
Simvastatin 1
CSF 1
TTC 1
Asn 1
Pravastatin 1
CTX 1
caffeine 1
-deoxyadenosine 1
Fragment 1
Bortezomib 1
Propidium 1
Herceptin 1
Parkin 1
Enzyme
caspase-7 920
caspase-7 896
caspase-3 551
caspase-9 228
PARP 176
caspase-8 142
caspase-6 77
mitogen-activated protein kinase 75
caspase-6 68
caspase-1 54
caspase-2 38
caspase-2 38
ERK 34
protein kinase 18
granzyme B 17
proteasome 14
MEK 14
caspase-4 13
cdc2 12
protein kinase C 12
caspase-4 11
focal adhesion kinase 10
catalase 9
superoxide dismutase 9
lactate dehydrogenase 7
ACS 6
MAP 6
GSK 5
glutathione S-transferase 5
caspase-10 5
glutathione peroxidase 5
caspase-10 5
aspartate aminotransferase 4
NADPH oxidase 4
endonuclease 4
glutathione reductase 4
AMP-activated protein kinase 4
alanine aminotransferase 4
trypsin 4
RNase 4
caspase-5 4
luciferase 4
ATPase 4
NADPH oxidase 3
creatine kinase 3
cathepsin G 3
RNase 3
elastase 3
ECH 3
thrombin 3
calcineurin 3
cathepsin D 3
DNase 3
phospholipase C 3
caspase-11 3
Omi/HtrA2 3
caspase-11 3
topoisomerase 3
phosphoinositide 3-kinase 3
topoisomerase 3
m-calpain 3
reverse transcriptase 3
myosin light chain kinase 3
caspase-5 2
CAD 2
AMPK 2
P-glycoprotein 2
NQO1 2
succinate dehydrogenase 2
thymidylate synthase 2
complex I 2
CAD 2
CAD 2
DNA methyltransferase 2
sphingosine kinase 2
prolyl hydroxylase 2
DNA polymerase 2
IKK 2
peroxiredoxin 2
AMPK 2
mu-calpain 2
aspartase 2
legumain 2
cathepsin B 2
cathepsin L 1
demethylase 1
chitinase 1
cathepsin C 1
DNA ligase 1
cathepsin K 1
polo-like kinase 1 1
ribonuclease 1
deoxycytidine kinase 1
MEKK1 1
firefly luciferase 1
DNA ligase 1
ACE 1
RNase T1 1
neutrophil elastase 1
PTPase 1
ribonuclease 1
SNO 1
glyceraldehyde-3-phosphate dehydrogenase 1
lysozyme 1
beta-glucosidase 1
MAT 1
AST 1
beta-glucosidase 1
subtilisin 1
APC 1
Tpa 1
lipase 1
urokinase-type plasminogen activator 1
prostate-specific antigen 1
MAT 1
TSP-1 1
ALDH 1
Alternating 1
beta-lactamase 1
PHT 1
arginase 1
thermolysin 1
stromelysin-3 1
collagenase 1
monoamine oxidase 1
diamine oxidase 1
phosphatidylinositol 3-kinase 1
acetylcholinesterase 1
peroxidase 1
TdT 1
HSD 1
MDR 1
lipoxygenase 1
MPP 1
adenosine kinase 1
Compound
DNA 155
Dec 77
oxygen 69
cysteine 49
Asp 43
MDA 34
MTT 33
ADP-ribose 26
glucose 23
TNF 23
calcium 20
ADP 18
iodine 17
dUTP 16
ATP 16
ADP 16
ADP 16
tyrosine 15
alanine 14
bromide 13
sodium 13
serine 12
hydrogen 11
N-acetylcysteine 10
MEK 10
aldehyde 9
aldehyde 9
lysine 9
Clin 9
Hoechst 33342 8
acridine 8
water 8
zinc 8
GSH 7
ethyl acetate 7
aspartic acid 7
boron 7
dATP 7
aspartic acid 7
aspartic acid 7
aspartic acid 7
GSH 7
ACS 6
MAP 6
ACS 6
nitrogen 6
ethanol 6
glutamate 6
Acrolein 5
copper 5
kaempferol 5
ASC 5
acetate 5
NH2 5
MTS 5
Curcumin 5
chalcone 5
leucine 5
arginine 5
threonine 5
galactose 4
H2O2 4
DDP 4
Cytochrome c 4
phosphate 4
ATF 4
Paclitaxel 4
COS 4
glutamic acid 4
methionine 3
DMSO 3
potassium 3
Cordycepin 3
selenium 3
sulfate 3
valine 3
Isoliquiritigenin 3
Cer 3
indole-3-carbinol 3
Cordycepin 3
iron 3
anthracene 3
NADPH 3
NAD 3
glutamine 3
Cordycepin 3
Phe 3
NADPH 3
Melatonin 3
5-FU 3
retinoic acid 2
Staurosporine 2
salt 2
Panam 2
ammonium 2
Adriamycin 2
Rottlerin 2
THP 2
CTX 2
Estrogen 2
His 2
naphthoquinone 2
AMP 2
ICI 2
nickel 2
methanol 2
Oridonin 2
ABL 2
naphthoquinone 2
PEG 2
Rottlerin 2
silver 2
Propofol 2
COX 2
Rottlerin 2
HMG-CoA 2
NAD 2
DBA 2
Neuronal 2
Estrogen 2
ADR 2
tert-butyl hydroperoxide 2
Wortmannin 2
CO2 2
fluorine 2
VP-16 2
Pac 2
pyrene 2
DMI 2
benzene 2
TNM 2
5-HETE 2
naphthoquinone 2
naphthalene 2
DMI 2
naphthoquinone 2
naphthoquinone 2
cyanide 2
XTT 2
Gly 2
MSM 2
DPPH 2
C-3 2
Foscan 2
BCR 2
nitric oxide 2
naphthoquinone 2
acetic acid 2
THP 2
Ribose 2
DMS 2
Quercetin 2
pyridine 2
naphthoquinone 2
cGMP 2
Staurosporine 2
Ile 2
Lac 1
Geldanamycin 1
DNP 1
more...