Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.60 (
caspase-7
)
920
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The cysteine protease
caspase-7
has an established role in the execution of apoptotic cell death, but recent findings also suggest involvement of
caspase-7
during the host response to microbial infection. Caspase-7 can be cleaved by the inflammatory caspase, caspase-1, and has been implicated in processing and activation of microbial virulence factors. Thus,
caspase-7
function during microbial infection may be complex, and its role in infection and immunity has yet to be fully elucidated. Here we demonstrate that
caspase-7
is cleaved during cytosolic infection with the intracellular bacterial pathogen, Listeria monocytogenes. Cleavage of
caspase-7
during L. monocytogenes infection did not require caspase-1 or key adaptors of the primary pathways of innate immune signaling in this infection, ASC,
RIP2
and MyD88. Caspase-7 protected infected macrophages against plasma membrane damage attributable to the bacterial pore-forming toxin Listeriolysin O (LLO). LLO-mediated membrane damage could itself trigger
caspase-7
cleavage, independently of infection or overt cell death. We also detected
caspase-7
cleavage upon treatment with other bacterial pore-forming toxins, but not in response to detergents. Taken together, our results support a model where cleavage of
caspase-7
is a consequence of toxin-mediated membrane damage, a common occurrence during infection. We propose that host activation of
caspase-7
in response to pore formation represents an adaptive mechanism by which host cells can protect membrane integrity during infection.
...
PMID:Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response. 2280 71
