Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.60 (
caspase-7
)
920
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of this study was to elucidate the role of
SUMO-1
modification in
caspase-7
in neuronal cells. We have previously demonstrated that procaspase-2 could be a possible target for
SUMO-1
modification. In the present study, we attempted to investigate whether other caspases also interact with Ubc9/
SUMO-1
. The specific binding of
SUMO-1
with
caspase-7
was observed in mammalian cells. Deletion mutant analysis revealed that a
SUMO-1
modification site may be located in at least N-terminal p20 subunit of
caspase-7
. Furthermore,
SUMO-1
-modified
caspase-7
appeared as a dot-like structure in nuclear localization. These findings suggest that
SUMO-1
modification in
caspase-7
may be linked to specific its localization in the nucleus and may therefore contribute to the cleavage of nuclear substrates during neuronal apoptosis.
...
PMID:Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells. 1637 84
