Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.60 (
caspase-7
)
920
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have identified and characterized a novel cysteine protease named
CMH-1
that is a new member of the interleukin 1 beta converting enzyme (ICE) family of proteases with substrate specificity for Asp-X.
CMH-1
has the highest similarity to CPP32 (52% amino acid identity) and
MCH2
(31% identical).
CMH-1
shares conserved amino acid residues that form the core structure of ICE as well as those residues involved in catalysis and in the P1 aspartate binding. Overexpression of
CMH-1
in COS cells resulted in the processing of
CMH-1
and the induction of apoptosis of transfected cells. Coexpression of
CMH-1
with poly(ADP-ribose) polymerase (PARP) also resulted in a specific cleavage of PARP. Purified recombinant
CMH-1
cleaved PARP but not interleukin 1 beta precursor in vitro.
...
PMID:Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. 856 22
