Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.60 (
caspase-7
)
920
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present study explored the effect of
telomerase reverse transcriptase
(
TERT
) on the growth and apoptosis of fibrosarcoma, and investigated the potential molecular signalling pathways underlying its effect. A plasmid was constructed in order to overexpress
TERT
and siRNA was used to knockdown
TERT
. The effect of
TERT
on fibrosarcoma cells
in vitro
was studied by performing reverse transcription-quantitative PCR and western blotting to determine the expression of p53, survivin, caspase-3,
caspase-7
and PKB. Knockdown of
TERT
suppressed cell growth, decreased fibrosarcoma volume, decreased survivin and PKB expression, and increased caspase-3 expression. The results of the present study suggest that
TERT
regulates the growth of fibrosarcoma
in vitro
and
in vivo
, and that this is associated with the expression of caspase-3 and survivin, in addition to the PKB signalling pathway.
...
PMID:Effect of TERT on the growth of fibrosarcoma via caspase-3, survivin and PKB. 2878 28
