Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.22.6 (
chymopapain
)
407
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A study has been made of the mechanism of action of intradiscal injections of preparations of
chymopapain
in the treatment of sciatica. Such preparations were found to contain at least four distinct proteins, but enzymatically active
chymopapain
was the component mainly responsible for releasing glycosaminoglycan from cartilaginous tissue. Previous suggestions that an electrostatic interaction between
chymopapain
and glycosaminoglycan is important to the action of injected enzyme were not supported by the finding that both positively and negatively charged forms of
chymopapain
efficiently released glycosaminoglycan from cartilaginous tissue. In contrast, cysteine alone did not cause release of glycosaminoglycan. Chymopapain was found to be inhibited efficiently by the protein inhibitors,
cystatin C
and low molecular weight kininogen in vitro, and the possible relevance of this finding to the efficacy and safety of chemonucleolysis is discussed.
...
PMID:The biochemistry of the action of chymopapain in relief of sciatica. 378 40
