Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.6 (chymopapain)
 407 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chymopapain degrades the nucleus pulposus portion of the intervertebral disk of rabbits. The degradation is not grossly visible until 15 days post-injection. Depolymerization of the chondromucoprotein and decreases in the ability of a disk to imbibe fluid, is, in effect, a "chemical decompression" of the nucleur pulposus. The enzyme must come into direct contact with the chondromucoprotein complex of the disk material, and to a significant extent also must reach the area of disk material adjacent to the herniated annulus. Rapid depolymerization of the chondromucoprotein complex on a biomechanical level, and "decompression" of disk material on a biomechanical level can be correlated with relief of pain in all types of disk herniation in human beings. A primary biochemical change in the disk material would lead to a secondary decrease in inflammation if the change led to a "decompression" of the chondromucoprotein. Since the primary effect of chymopapain is on the chondromucoprotein of the disk, beneficial results would not be expected if nerve root compression is due to bony impingement or scar tissue following previous surgery. Chymopapain did not seem to possess any anti-inflammatory properties when bone was used as an irritant under a nerve root. However, this was technically difficult to evaluate and the possibility that chymopapain may also interfere with a chemical mediator of pain or interfere directly with an inflammatory reaction secondary to root compression can not be excluded.
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PMID:Experimental studies on the effect of chymopapain on nerve root compression caused by intervertebral disk material. 112 86

A prospective study was carried out on the results of chemonucleolysis or surgery in 156 patients who had lumbar disc herniations. All patients were considered as potentially good candidates for chemonucleolysis. Seventy-two received a chymopapain injection and 84 underwent surgery. Based on computerized tomography (CT) scan and/or myelography the herniations were distinguished as small, medium, and large. Also distinguished were three types of preoperative clinical patterns, Type A, Type B and Type C, corresponding to slight, moderate, and severe nerve root compression, respectively. Follow-up evaluations were made 1 month, 3 months, and an average of 2.8 years after treatment. The patients with a small disc herniation, who underwent chemonucleolysis, did slightly better as a group than those treated surgically. At 1 month, the proportions of satisfactory results were 75% in the chemonucleolysis group and 62% in the surgery series. At final follow-up, the proportions were 84% and 82%, respectively, but the ratio of excellent-to-good results was higher in the chemonucleolysis group. In the latter, most patients with satisfactory outcomes had a Type A or Type B clinical pattern. In medium-size herniations the results of surgery were slightly better than those of chemonucleolysis. At 1 month, 55% of patients in the chemonucleolysis group had satisfactory results compared with 74% of those in the surgery series; at final follow-up the proportions were, respectively, 76% and 86%. In the chemonucleolysis group most satisfactory outcomes were found in patients with a Type A or Type B clinical pattern. The results of chemonucleolysis in patients who had large herniations were significantly inferior to those of surgery: at final follow-up the results were satisfactory in 50% of patients in the chemonucleolysis group and 89% of those in the surgery series. Chemonucleolysis appears to be the treatment of choice in most patients with small disc herniations and an effective alternative to surgery in most patients with medium-size herniations when the preoperative clinical pattern indicates a slight or moderate nerve root compression. In all large herniations and in small- or medium-size herniations causing a severe nerve root impingement, surgery should be preferred to chemonucleolysis.
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PMID:Chemonucleolysis versus surgery in lumbar disc herniations: correlation of the results to preoperative clinical pattern and size of the herniation. 329 36