Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.22.56 (caspase-3)
 35,750 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
gamma-glutamyltransferase 2 9.8
Homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein 9.8
ubiquitin specific protease 2 9.8
ACIN1 protein 9.8
BRI3-binding protein 9.8
AMPH1 9.8
CMH1 9.8
C1orf201 9.8
zinc finger protein 224 9.8
Minichromosome maintenance complex component 3 9.8
zinc finger protein 800 9.8
ALS2CR7 9.8
DDX46 protein 9.8
hect domain and RLD 5 9.8
LOC401317 9.8
troponin I, cardiac 9.8
interleukin-12 p35 subunit 9.8
Glyoxylate reductase/hydroxypyruvate reductase 9.8
Death associated protein 3 9.8
IRX5 protein 9.8
DAGD 9.8
caspase and RIP adapter with death domain 9.8
tetratricopeptide repeat domain 9C 9.8
CPP32 9.5
caspase-3 9.4
p21, Cip1 9.2
CMH-1 9.1
DFF35 9.1
caspase-9 8.8
Polypeptide N-acetylgalactosaminyltransferase 14 8.8
Prune homolog 2 (Drosophila) 8.8
Cell death activator 8.8
D4S234E 8.8
G protein-coupled receptor 34 8.8
RING finger protein 121 8.8
Transient receptor potential cation channel, subfamily V, member 1 8.8
C4orf22 8.8
Sal-like 4 (Drosophila) 8.8
tropomyosin 3 isoform 2 8.8
Apoptotic peptidase activating factor 1 8.8
anti-Mullerian hormone receptor type II 8.8
TDE1 8.8
transmembrane protein 117 8.8
p21 protein (Cdc42/Rac)-activated kinase 3 8.8
RAN binding protein 9 8.8
TBC1D19 8.8
Engulfment and cell motility protein 1 8.8
bridging integrator 2 8.8
sterile alpha motif and leucine zipper containing kinase AZK 8.8
LGP1 8.8
ICH-2 8.7
Caspase-activated DNase 8.5
ICH-1L 8.5
ICAD 8.4
NAIP protein 8.4
caspase-activated DNase 8.3
caspase-8 8.3
HSPA12B protein 8.2
Isochorismatase domain-containing protein 1 8.2
CT57 8.2
GATA zinc finger domain containing 2A 8.2
Tumor suppressor candidate 4 8.2
MKPX 8.2
Chondroitin synthase 8.2
acyl-CoA synthetase family member 2 8.2
cytochrome c oxidase subunit VIa polypeptide 1 8.2
FPTB 8.2
MRPS2 8.2
SCC-112 8.2
Phosphoribosyl pyrophosphate synthetase 1 8.2
polymerase-like protein 8.2
TEX27 8.2
Paired box gene 9 8.2
mast cell-expressed membrane protein 1 8.2
PTPRK protein 8.2
AD14 8.2
PDZ domain containing 2 8.2
cysteine-rich protein 3 8.2
Forkhead box L1 8.2
KHDC1 8.2
more...
Disease
CMH1 9.8
Bovine tritrichomonosis 8.8
Non-bacterial prostatitis 8.2
DFNA24 8.2
POF4 7.8
HMN7B 7.8
PFM2 7.8
Alcoholic liver damage 7.5
Retinal microaneurysms 7.5
recurrent gallbladder cancer 7.2
nutmeg liver 7.0
Radiocontrast nephropathy 7.0
Ischemic cerebral infarction 7.0
Brain Ischemia 7.0
Malignant insulinoma 6.8
Neonatal pneumonia 6.6
Neonatal necrotizing enterocolitis 6.6
Impaired social interaction 6.6
Fowl cholera 6.6
Proteus mirabilis infection 6.5
DECD 6.5
endometrial adenoacanthoma 6.5
Eimeriosis 6.5
Coliform mastitis 6.5
Diabetic encephalopathy 6.4
DFNA5 6.4
cerebral ischemia/hypoxia 6.3
Reovirus infection 6.3
lung sarcoma 6.1
ADLTE 6.1
Middle cerebral artery occlusion 6.1
Neonatal anoxia 6.0
neck neoplasm 5.9
androgen independent prostate cancer 5.9
Hereditary periodic fever 5.9
Thromboembolic stroke 5.9
oral neoplasm 5.8
methionine synthase deficiency 5.8
IHG 5.8
Glycogen storage disease type Ib 5.8
heterophyiasis 5.7
Intestinal ischemia 5.6
AGS 5.6
Testicular torsion 5.6
salivary gland adenoid cystic carcinoma 5.6
DEND 5.6
Granular corneal dystrophy 5.6
gastric cancer stage 5.6
NINA 5.6
Viral myocarditis 5.5
Progression of prostate cancer 5.5
Avian encephalomyelitis 5.4
CGL2 5.4
MTS 5.4
mouse leukemia L1210 5.4
testicular dysfunction 5.4
B-cell lymphoma 5.4
Branch retinal vein occlusion 5.3
HIDS 5.3
Acute respiratory distress 5.3
DFNB12 5.2
Ehrlich Ascites Tumor 5.2
BLL 5.2
WM1 5.2
Retinal ischemia 5.2
Hemophilic arthropathy 5.1
Oral carcinoma 5.0
renal ischemia 5.0
Burkitt-like lymphoma 5.0
DDP 5.0
Retinal damage 5.0
Leukemia stem cell 5.0
connective tissue hyperplasia 4.9
myocardial hypoxia 4.9
OBX 4.9
Osteosarcoma 4.9
Osteosarcoma 4.9
Sepsis-associated encephalopathy 4.9
cochlear lesion 4.9
GSH 4.9
more...
Symptom
Chronic pelvic pain syndrome 4.9
not coping 4.6
sinus congestion 4.5
Motor dysfunction 4.4
Ear swelling 3.8
Circling 3.8
Inflammatory pain 3.6
Scratch 3.5
skin damage 3.5
Behavioral symptoms 3.4
hyperoxia 3.4
functional recovery 3.2
infant diarrhea 3.0
collapse 3.0
disturbed balance 3.0
stomach pain 2.8
Acute urinary retention 2.8
Joint hypermobility 2.8
memory loss 2.7
Anoxia 2.7
bradykinesia 2.7
startle reaction 2.5
neurological disability 2.5
starvation 2.4
POA 2.3
Tenderness 2.2
impaired motor coordination 2.2
loss of balance 2.0
hypothermia 1.9
incoordination 1.8
male subfertility 1.7
Neuropathic pain 1.7
halitosis 1.6
cachexia 1.6
hyperemesis 1.6
HSA 1.4
forgetfulness 1.4
acute stress 1.3
loss of taste 1.3
dry eye 1.2
thinning 1.0
motor symptom 0.9
seizures 0.9
respiratory distress 0.9
chorea 0.8
hyperesthesia 0.7
abdominal cramps 0.7
Decreased activity 0.7
ataxic gait 0.7
ketonuria 0.7
personality change 0.7
sore throat 0.4
bitter taste 0.3
ataxia 0.2
physical appearance 0.2
despair 0.1
menopausal symptoms 0.1
tachypnea 0.1
clubbing -0.0
cerebellar ataxia -0.0
exhaustion -0.0
DNA marker -0.1
diarrhea -0.1
anesthesia -0.1
otalgia -0.2
tremor -0.2
eds -0.3
muscle rigidity -0.3
catatonia -0.3
urinary frequency -0.3
abnormal gait -0.3
hypercapnia -0.3
decreased appetite -0.4
chronic constipation -0.5
tonic-clonic seizure -0.6
nasal discharge -0.6
acidity -0.6
weakness -0.7
hepatosplenomegaly -0.7
anosmia -0.8
more...
Drug
Edratide 9.8
Lexatumumab 8.8
Alisma rhizome 8.8
Condurango 8.8
Teroxirone 8.5
Alsterpaullone 7.8
P-Nitrophenol 7.8
Saccharin sodium 7.8
Mapatumumab 7.5
Montirelin 7.5
Scutellaria root 7.4
Advexin 7.3
Purvalanol 7.3
2-Iminobiotin 7.2
Diammonium glycyrrhizinate 7.0
Tandutinib 7.0
Alexidine 6.8
7,8-Dihydroneopterin 6.8
CED 6.6
Cassia seed 6.6
Bupleurum root 6.6
Balhimycin 6.6
Angelica dahurica root 6.6
3-Methyladenine 6.5
Limaprost 6.5
Lemon oil 6.5
Proflavin 6.5
3-Methoxybenzamide 6.5
Zedoary 6.5
Bear bile 6.3
Bv2 6.3
Epothilone B 6.3
Avasimibe 6.2
Flurbiprofen axetil 6.1
Lestaurtinib 6.1
Berberine chloride 6.0
Sodium phenylbutyrate 6.0
CA-074 6.0
Ulinastatin 6.0
Mevastatin 6.0
Sodium metabisulfite 5.9
Fasudil hydrochloride 5.9
Platonin 5.9
Benidipine hydrochloride 5.9
Polaprezinc 5.8
Irofulven 5.8
Cupric sulfate 5.8
Citrus unshiu peel 5.7
Quinaprilat 5.7
Coix seed 5.7
Arsenic trioxide 5.7
Teduglutide 5.7
Benfotiamine 5.7
AMC 5.6
ROS 5.6
Tacalcitol 5.6
Gardenia fruit 5.6
Cilengitide 5.6
Atractylodes rhizome 5.6
Propidium 5.6
2-Methoxyestradiol 5.6
Flavopiridol 5.6
Emodin 5.6
Naftopidil 5.5
Butaprost 5.4
Oxfenicine 5.4
Hyperforin 5.3
Iodophenyl 5.3
Lipoic Acid 5.3
Nepafenac 5.3
Emodin 5.3
Zebularine 5.3
Sivelestat 5.2
PFT 5.2
Safflower 5.2
Tepoxalin 5.2
Penfluridol 5.2
Ciglitazone 5.1
Motexafin gadolinium 5.1
Crotonaldehyde 5.1
more...
Enzyme
caspase-3 9.8
caspase-9 9.1
caspase-7 9.1
caspase-7 9.0
caspase-6 8.8
holocytochrome c synthetase 8.8
caspase-6 8.8
caspase-8 8.7
caspase-2 8.4
caspase-2 8.4
caspase-10 8.2
caspase-10 8.2
PARP 7.8
caspase-4 7.7
caspase-4 7.6
Omi/HtrA2 7.2
D-2-hydroxy acid dehydrogenase 6.8
caspase-5 6.7
caspase-1 6.7
caspase-5 6.6
caspase-11 6.5
caspase-11 6.5
TdT 6.4
mu-calpain 6.3
m-calpain 6.2
MPP 6.0
BCKA 5.7
HPRP 5.6
MT 1 5.6
aspartate dehydrogenase 5.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.5
GSK 5.3
neutral sphingomyelinase 5.2
ceramide synthetase 5.2
aspartase 5.1
mitogen-activated protein kinase 5.0
granzyme B 5.0
phosphoinositide 3-kinase 4.9
cdc2 4.9
lactate dehydrogenase 4.8
phosphatidylinositol 3-kinase 4.8
palmitoyl-protein thioesterase 4.8
superoxide dismutase 4.8
ceramidase 4.7
glutathione peroxidase 4.7
MMP 4.7
sphingosine kinase 4.6
AO1 4.6
cathepsin B 4.6
isochorismatase 4.6
inositol 3-kinase 4.5
3-hydroxy-3-methylglutaryl-CoA lyase 4.5
sphingomyelin synthase 4.5
heme oxygenase 4.4
SNO 4.4
STK4 4.4
granzyme K 4.4
GK2 4.3
AMPK 4.3
polysaccharide deacetylase 4.3
HK2 4.3
MEK 4.2
cathepsin X 4.2
catalase 4.2
AST 4.1
MEKK1 4.1
NADPH oxidase 4.1
AMP-activated protein kinase 4.1
CNPase 4.0
electron transfer flavoprotein dehydrogenase 4.0
NADPH oxidase 4.0
cathepsin D 4.0
glutathione synthetase 4.0
proteinase-3 4.0
farnesyltransferase 3.9
aspartate aminotransferase 3.9
phospholipid hydroperoxide glutathione peroxidase 3.9
IKK 3.9
chondroitinase B 3.9
glucosylceramide synthase 3.9
more...
Compound
Podophyllotoxin acetate 9.8
estra-1,3,5(10)-trien-17-ol 9.8
crocetin-(beta-d-gentiobiosyl)-(beta-d-glucosyl)-ester 9.8
crocetin di-(beta-d-glucosyl)-ester 9.8
C25H28O6 9.8
C25H28O6 9.8
trans-Dihydronarciclasine 9.8
Altersolanol A 9.8
C26H30O6 9.8
C25H28O6 9.8
C25H28O6 9.8
Iodinin 9.8
Dentatin 8.8
4-chloro-1H-indole 8.8
4-chloro-N-methylbenzamide 8.8
Lunacridine 8.8
7-Deacetoxy-7-oxogedunin 8.8
C25H28O6 8.8
Wighteone 8.8
Abyssinone V 8.8
Armepavine 8.8
Methoxycamptothecin 8.8
Uvaretin 8.8
Gymnemic acid I 8.8
Lunacridine 8.8
Vitamin K4 8.8
Decylubiquinone 8.5
Sinularin 8.4
Ginsenoside Rf 8.2
Vitamin K4 8.2
2-Amino-3-hydroxypyridine 8.2
Sinulariolide 8.2
Lycopodine 8.2
ergosta-7,22-dien-3-ol 8.2
11H-indeno[1,2-b]quinoxaline 8.2
3-Hydroxybiphenyl 8.2
Dracorhodin 8.1
Quinalizarin 7.9
Dehydrocostus lactone 7.9
Scoulerine 7.8
Gluconasturtiin 7.8
GW 6471 7.8
24-Hydroxycholesterol 7.8
Cajanol 7.8
Kinetin riboside 7.8
Bellidifolin 7.8
Dehydrodieugenol 7.8
Auriculasin 7.8
4,6,8-trimethylazulene 7.8
Murrayanine 7.8
6-methylquinoxaline 7.8
methyl 3-oxo-3-phenylpropanoate 7.8
Sarcophine 7.8
Echinocystic acid 7.7
Methyl caffeate 7.6
Obacunone 7.6
Bongkrekic acid 7.6
Raddeanin A 7.6
N-Phenylmaleimide 7.5
Tectochrysin 7.5
Saucernetin 7.5
Nomilin 7.5
Xylopine 7.5
Kinetin riboside 7.5
4-chloroquinazoline 7.5
Tigogenin 7.5
11H-indeno[1,2-b]quinoline 7.5
Harmine hydrochloride 7.5
Theasinensin A 7.5
Tephrosin 7.5
C8H11N2O 7.5
Aspidin 7.5
Bufotalin 7.5
Lentiginosine 7.5
11H-indeno[1,2-b]quinoline 7.5
2-hexadecanol 7.5
1,8-dihydroxy-9(10H)-anthracenone 7.5
Ginkgetin 7.4
Apigetrin 7.3
Trichothecin 7.3
more...